S1RA (hydrochloride)
- Product Name
- S1RA (hydrochloride)
- CAS No.
- 1265917-14-3
- Chemical Name
- S1RA (hydrochloride)
- Synonyms
- 177303;S1RA. HCL;S1RA HCl (E-52862);S1RA (E-52862) HCI;S1RA (hydrochloride);E52862 hydrochloride;E 52862 hydrochloride;E-52862 hydrochloride;S1RA hydrochloride, 10 mM in DMSO;E-52862 HYDROCHLORIDE;E52862 HYDROCHLORIDE;E 52862 HYDROCHLORIDE
- CBNumber
- CB72682021
- Molecular Formula
- C20H24ClN3O2
- Formula Weight
- 373.88
- MOL File
- 1265917-14-3.mol
S1RA (hydrochloride) Property
- storage temp.
- -20°C (des.)
- solubility
- Soluble in DMSO (up to at least 25 mg/ml)
- form
- solid
- color
- Off-white
- Stability:
- Stable for 1 year as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P312Call a POISON CENTER or doctor/physician if you feel unwell.
P321Specific treatment (see … on this label).
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P337+P313IF eye irritation persists: Get medical advice/attention.
P362Take off contaminated clothing and wash before reuse.
P403+P233Store in a well-ventilated place. Keep container tightly closed.
P405Store locked up.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- CS-2188
- Product name
- S1RAhydrochloride
- Purity
- 99.24%
- Packaging
- 5mg
- Price
- $110
- Updated
- 2021/12/16
- Product number
- CS-2188
- Product name
- S1RAhydrochloride
- Purity
- 99.24%
- Packaging
- 10mg
- Price
- $165
- Updated
- 2021/12/16
- Product number
- BS177543
- Product name
- S1RA hydrochloride
- Packaging
- 25mg
- Price
- $240
- Updated
- 2021/12/16
- Product number
- BS177543
- Product name
- S1RA hydrochloride
- Packaging
- 50mg
- Price
- $320
- Updated
- 2021/12/16
- Product number
- CS-2188
- Product name
- S1RAhydrochloride
- Purity
- 99.24%
- Packaging
- 50mg
- Price
- $550
- Updated
- 2021/12/16
S1RA (hydrochloride) Chemical Properties,Usage,Production
Description
S1RA (E-52862, 1265917-14-3) is a potent and selective σ1 antagonist with weak binding at σ2?(IC50?σ1 = 17nM, σ2 = 9300nM).1,2?S1RA abolished mechanical and thermal hyperalgesia in mice with carrageenan-induced acute inflammation by enhancing the action of endogenous opioid peptides of immune origin in a σ1 dependent manner.3?S1RA potentiated μ-opioid antinociception in mice in a σ-dependent manner.4?S1RA displayed neuroprotective effects in a mouse model of ischemic stroke.5
Uses
S1RA (E-52862) hydrochloride is an orally active and selective sigma-1 receptor (σ1R) antagonist with a Ki value of 17 nM. S1RA hydrochloride shows good selectivity against σ2R (Ki >1000 nM). S1RA hydrochloride is a human 5-HT2B receptor antagonist with an IC50 value of 4.7 μM. S1RA hydrochloride inhibits neuropathic pain and activity-induced spinal sensitization[1][2].
in vivo
S1RA hydrochloride (i.p. 16-80 mg/kg or oral administration 32-128 mg/kg; once) dose-dependently inhibits formalin-induced nociception, capsaicin-induced mechanical hypersensitivity and sciatic nerve injury-induced mechanical and thermal hypersensitivity of mice[1].
| Animal Model: | Male CD1 mice[1] |
| Dosage: | 32, 64, 128 and 160 mg/kg |
| Administration: | Intraperitoneal injection; 32, 64, 128 and 160 mg/kg, once |
| Result: | Reduced the permanence time on the rotating rod in rotarod test. |
| Animal Model: | Male CD1 mice with formalin-evoked nociception[1] |
| Dosage: | 20, 40 and 80 mg/kg |
| Administration: | Intraperitoneal injection; 20, 40 and 80 mg/kg, once |
| Result: | Dose-dependently showed analgesic effect on of formalin-evoked nociceptive behaviours of mice. |
| Animal Model: | Male CD1 mice with capsaicin-induced mechanical hypersensitivity[1] |
| Dosage: | 16, 32 and 64 mg/kg (i.p.); 32, 64 and 128 mg/kg (oral administration) |
| Administration: | Intraperitoneal injection or oral administration; 16, 32 and 64 mg/kg (i.p.); 32, 64 and 128 mg/kg (oral administration), once |
| Result: | Dose-dependently reversed capsaicin-induced mechanical hypersensitivity in mice. |
IC 50
Sigma 1 Receptor
References
[1] SIEMENS H, ROODT V. References and Citations[C]. 2008: 0. DOI:10.1515/9783110217339.0.xiii
S1RA (hydrochloride) Preparation Products And Raw materials
Raw materials
Preparation Products
S1RA (hydrochloride) Suppliers
- Tel
- 021-58955995
- Fax
- 609-228-5909
- sales@medchemexpress.cn
- Country
- United States
- ProdList
- 4861
- Advantage
- 58
- Tel
- +1-800-259-7612
- Fax
- +1-800-259-7612
- info@musechem.com
- Country
- United States
- ProdList
- 4660
- Advantage
- 60
- Tel
- +1-781-999-5354; +17819995354
- marketing@targetmol.com
- Country
- United States
- ProdList
- 32435
- Advantage
- 58
- Tel
- +1-708-310-1919 +1-13798911105
- Fax
- 708-557-7486
- sales@invivochem.cn
- Country
- United States
- ProdList
- 6391
- Advantage
- 58
- Tel
- +1-781-999-5354;
- support@targetmol.com
- Country
- United States
- ProdList
- 39035
- Advantage
- 58
- Tel
- --
- Fax
- --
- sales@apexbt.com
- Country
- United States
- ProdList
- 6251
- Advantage
- 58
- Tel
- 16314854226
- info@bocsci.com
- Country
- United States
- ProdList
- 9923
- Advantage
- 65
- Tel
- --
- Fax
- --
- sales@focusbiomolecules.com
- Country
- United States
- ProdList
- 1284
- Advantage
- 58
- Tel
- --
- Fax
- --
- cayman@caymanchem.com
- Country
- United States
- ProdList
- 6213
- Advantage
- 81