ChemicalBook > CAS DataBase List > AcotiaMide

AcotiaMide

Product Name: AcotiaMide
CAS No.: 185106-16-5
Chemical Name: AcotiaMide
Synonyms: Acofide;AcotiaMide;ACOTIAMIDUM;Acotiamide D4;YM443 free base;Z-338 free base;Acotiamide formate salt;N-{2-[bis(1-methylethyl)amino]ethyl}-2-{[(2-hydroxy-4,5-dime...;N-[2-[Bis(1-methylethyl)amino]ethyl]-2-[(2-hydroxy-4,5-dimethoxybenzoyl)amino]-4-thiazolecarboxamide;N-(2-(diisopropylamino)ethyl)-2-(2-hydroxy-4,5-dimethoxybenzamido)thiazole-4-carboxamide hydrochloride
CBNumber: CB72683927
Molecular Formula: C21H30N4O5S
Formula Weight: 450.55
MOL File: 185106-16-5.mol

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AcotiaMide Property

Density: 1.246±0.06 g/cm3(Predicted)
storage temp.: -20°C
pka: 7.38±0.50(Predicted)
form: powder
color: white to beige
Water Solubility: H2O: 20mg/mL, clear

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: SML1569
Product name: Acotiamide dihydrochloride
Purity: ≥98% (HPLC)
Packaging: 5 mg
Price: $67.92
Updated: 2025/07/31

Sigma-Aldrich

Product number: SML1569
Product name: Acotiamide dihydrochloride
Purity: ≥98% (HPLC)
Packaging: 25 mg
Price: $380
Updated: 2025/07/31

DC Chemicals

Product number: DC8798
Product name: Acotiamide
Purity: >98%
Packaging: 100mg
Price: $200
Updated: 2021/12/16

DC Chemicals

Product number: DC8798
Product name: Acotiamide
Purity: >98%
Packaging: 250mg
Price: $400
Updated: 2021/12/16

CSNpharm

Product number: CSN19809
Product name: Acotiamide
Packaging: 50mg
Price: $424
Updated: 2021/12/16

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AcotiaMide Chemical Properties,Usage,Production

Uses

Acotiamide is an orally active, selective and reversible acetylcholinesterase (AChE) inhibitor, with an IC50 of 1.79 μM. Acotiamide can enhance gastric contractility and accelerate delayed gastric emptying. Acotiamide has the potential for the research of functional dyspepsia involving gastric motility dysfunction and intestinal inflammatory[1][2][3].

Definition

ChEBI: Acotiamide is a member of salicylamides.

Biological Activity

Acotiamide is a potent, selective and reversible inhibitor of human and canine stomach-derived acetylcholinesterase (AChE). Acotiamide showed no affinity for dopamine D2 or serotonin 5-HT4 receptors but does have activity as a muscarinic antagonist. It acts as a prokinetic drug through acetylcholinesterase inhibition and muscarinic receptor antagonism, and has been used for the treatment of functional dyspepsia (FD) involving gastric motility dysfunction.

in vivo

Acotiamide (0.3, 1, 3 mg/kg; i.v./3, 10, 30 mg/kg; p.o.) increases the postprandial gastric motility index in a dose-dependent manner^[2].
Acotiamide (0.83 mg/kg; i.v.; once) inhibits AChE in rat stomach with an IC₅₀ value of 1.79 μM^[3].

Animal Model:	Male mongrel dogs (9-11 kg), Male beagle dogs (9.6-12.9 kg)^[2]
Dosage:	0.3, 1, 3, 10, 30 mg/kg
Administration:	Intravenous injection; once
Result:	Increased the postprandial gastric motility.

Animal Model:	Male Sprague-Dawley rats (aged 6-7 weeks)^[3]
Dosage:	0.83 mg/kg
Administration:	Intravenous injection; once.
Result:	Effectively improved functional dyspepsia by inhibiting AChE in rat stomach.

References

[1] Kazuyoshi Y oshii, et al. Physiologically-Based Pharmacokinetic and Pharmacodynamic Modeling for the Inhibition of Acetylcholinesterase by Acotiamide, A Novel Gastroprokinetic Agent for the Treatment of Functional Dyspepsia, in Rat Stomach. Pharmaceutical DOI:10.1007/s11095-015-1787-y
[2] Hiroshi Yamawaki, et al. Acotiamide attenuates central urocortin 2-induced intestinal inflammatory responses, and urocortin 2 treatment reduces TNF-α productions in LPS-stimulated macrophage cell lines. Neurogastroenterol Motil. 2020 Aug;32(8):e13813. DOI:10.1111/nmo.13813
[3] Matsunaga Y, Acotiamide hydrochloride (Z-338), a new selective acetylcholinesterase inhibitor, enhances gastric motility without prolonging QT interval in dogs: comparison with cisapride, itopride, and mosapride. J Pharmacol Exp Ther. 2011 Mar;336(3):791- DOI:10.1124/jpet.110.174847

AcotiaMide Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from AcotiaMide manufacturers

Moxin Chemicals

Product: Acotiamide 185106-16-5
Price: US $0.00-0.00/mg
Min. Order: 10mg
Purity: 95%+
Supply Ability: 10000000
Release date: 2025-02-27

Hebei Mingeng Biotechnology Co., Ltd

Product: Acotiamide 185106-16-5
Price: US $200.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 1000kg/Month
Release date: 2022-11-27

Nanjing Kaitian Chemical Co., LTD

Product: AcotiaMide 185106-16-5
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 100kg
Release date: 2023-02-10

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AcotiaMide

N-[2-[Bis(1-methylethyl)amino]ethyl]-2-[(2-hydroxy-4,5-dimethoxybenzoyl)amino]-4-thiazolecarboxamide

N-(2-(diisopropylamino)ethyl)-2-(2-hydroxy-4,5-dimethoxybenzamido)thiazole-4-carboxamide hydrochloride

ACOTIAMIDUM

Acofide

N-{2-[bis(1-methylethyl)amino]ethyl}-2-{[(2-hydroxy-4,5-dimethoxyphenyl)carbonyl]amino}-1,3-thiazole-4-carboxamide

4-Thiazolecarboxamide, N-[2-[bis(1-methylethyl)amino]ethyl]-2-[(2-hydroxy-4,5-dimethoxybenzoyl)amino]-

Acotiamide formate salt

N-{2-[bis(1-methylethyl)amino]ethyl}-2-{[(2-hydroxy-4,5-dime...

Acotiamide D4

Acotiamide D6Q: What is Acotiamide D6 Q: What is the CAS Number of Acotiamide D6 Q: What is the storage condition of Acotiamide D6 Q: What are the applications of Acotiamide D6

YM443 free base

Z-338 free base

185106-16-5

C21H30N4O5S