Bazedoxifene
- Product Name
- Bazedoxifene
- CAS No.
- 198481-32-2
- Chemical Name
- Bazedoxifene
- Synonyms
- Tse-424;CS-1993;Batoxifene;Bazedoxifen;Bazedoxifene;Bazedoxifeno;Unii-Q16tt9C5bk;BAZEDOXIFENE BASE;Bazedoxifene [inn];Bazedoxifene free base
- CBNumber
- CB01458163
- Molecular Formula
- C30H34N2O3
- Formula Weight
- 470.6
- MOL File
- 198481-32-2.mol
Bazedoxifene Property
- Melting point:
- 98-102°
- Boiling point:
- 694.4±55.0 °C(Predicted)
- Density
- 1.19
- storage temp.
- Sealed in dry,Store in freezer, under -20°C
- solubility
- Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly)
- form
- Solid
- pka
- 10.12±0.15(Predicted)
- color
- White to Very Dark Beige
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H360May damage fertility or the unborn child
- Precautionary statements
-
P201Obtain special instructions before use.
P202Do not handle until all safety precautions have been read and understood.
P281Use personal protective equipment as required.
P308+P313IF exposed or concerned: Get medical advice/attention.
P405Store locked up.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- B129245
- Product name
- Bazedoxifene
- Packaging
- 25mg
- Price
- $790
- Updated
- 2021/12/16
- Product number
- A3232
- Product name
- Bazedoxifene
- Packaging
- 5mg
- Price
- $142
- Updated
- 2021/12/16
- Product number
- A3232
- Product name
- Bazedoxifene
- Packaging
- 10mg
- Price
- $249
- Updated
- 2021/12/16
- Product number
- API0024680
- Product name
- BAZEDOXIFENE
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $502.94
- Updated
- 2021/12/16
- Product number
- A696565
- Product name
- Bazedoxifene
- Purity
- 98+%
- Packaging
- 5mg
- Price
- $109
- Updated
- 2021/12/16
Bazedoxifene Chemical Properties,Usage,Production
Uses
Bazedoxifene is an nonsteroidal selective estrogen receptor modulator (SERM). Bazedoxifene is used as an antiosteoporotic.
Definition
ChEBI: Bazedoxifene is a phenylindole.
General Description
Bazedoxifene, 1-[[4-[2-(azepan-1-yl)ethoxy]phenyl]methyl]-2-(4-hydroxyphenyl)-3-methylindol-5-ol (Viviant), was declared to be “approvable” bythe FDA in 2007 for the prevention of postmenopausalosteoporosis. As of mid-2009, final approval in the UnitedStates is still pending. Bazedoxifene was approved inEurope in 2009 for the treatment of post–menopausalosteoporosis.
Clinical Use
Bazedoxifene is an indole-based SERM that is under investigation for the treatment and prevention of postmenopausal osteoporosis. It also is being evaluated in combination with Premarin (conjugated estrogens). Bazedoxifene displaces 17β-estradiol from estrogen receptors and has excellent binding affinity for the receptor itself. Unlike raloxifene, this agent does not cause hot flashes at the doses required to have a beneficial effect on bone. In addition, it does not cause uterine or mammary gland stimulation.
Enzyme inhibitor
This potent and selective estrogen receptor modulator, or SERM (FW = 530.65 g/mol; CAS 198481-33-3; Solubility: 00 mM in DMSO), also named 1-[[4-[2- (hexahydro-1H-azepin-1-yl) ethoxy]phenyl]methyl]-2- (4- hydroxyphenyl) -3-methyl-1H-indol-5-ol, selectivity targets the extrogen receptor ERα (IC50 = 26 nM), with weaker action against ERβ (IC50 = 99 nM), inhibiting 17β-estradiol-induced proliferation of MCF-7 cells. Bazedoxifene represents a promising new treatment for osteoporosis, one with a potential for less uterine and vasomotor effects than selective estrogen receptor modulators now used clinically.
target
estrogen receptor
Bazedoxifene Preparation Products And Raw materials
Raw materials
Preparation Products
Bazedoxifene Suppliers
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- Fax
- 86-21-57758967
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- China
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- Pls mail us for more information!
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- 028-81705658
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- Country
- China
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View Lastest Price from Bazedoxifene manufacturers
- Product
- Bazedoxifene 198481-32-2
- Price
- US $85.00-850.00/kg
- Min. Order
- 10kg
- Purity
- 0.99
- Supply Ability
- 20tons
- Release date
- 2023-10-31
- Product
- Bazedoxifene 198481-32-2
- Price
- US $0.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 20 TONS
- Release date
- 2022-11-07
- Product
- Bazedoxifene 198481-32-2
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 98%
- Supply Ability
- 100KG
- Release date
- 2019-09-18