Bazedoxifene
- Product Name
- Bazedoxifene
- CAS No.
- 198481-32-2
- Chemical Name
- Bazedoxifene
- Synonyms
- Tse-424;CS-1993;Batoxifene;Bazedoxifen;Bazedoxifene;Bazedoxifeno;Unii-Q16tt9C5bk;BAZEDOXIFENE BASE;Bazedoxifene [inn];Bazedoxifene free base
- CBNumber
- CB01458163
- Molecular Formula
- C30H34N2O3
- Formula Weight
- 470.6
- MOL File
- 198481-32-2.mol
Bazedoxifene Property
- Melting point:
- 98-102°
- Boiling point:
- 694.4±55.0 °C(Predicted)
- Density
- 1.19
- storage temp.
- Sealed in dry,Store in freezer, under -20°C
- solubility
- Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly)
- form
- Solid
- pka
- 10.12±0.15(Predicted)
- color
- White to Very Dark Beige
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H360May damage fertility or the unborn child
- Precautionary statements
-
P201Obtain special instructions before use.
P202Do not handle until all safety precautions have been read and understood.
P281Use personal protective equipment as required.
P308+P313IF exposed or concerned: Get medical advice/attention.
P405Store locked up.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- B129245
- Product name
- Bazedoxifene
- Packaging
- 25mg
- Price
- $790
- Updated
- 2021/12/16
- Product number
- A3232
- Product name
- Bazedoxifene
- Packaging
- 5mg
- Price
- $142
- Updated
- 2021/12/16
- Product number
- A3232
- Product name
- Bazedoxifene
- Packaging
- 10mg
- Price
- $249
- Updated
- 2021/12/16
- Product number
- API0024680
- Product name
- BAZEDOXIFENE
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $502.94
- Updated
- 2021/12/16
- Product number
- A696565
- Product name
- Bazedoxifene
- Purity
- 98+%
- Packaging
- 5mg
- Price
- $109
- Updated
- 2021/12/16
Bazedoxifene Chemical Properties,Usage,Production
Uses
Bazedoxifene is an nonsteroidal selective estrogen receptor modulator (SERM). Bazedoxifene is used as an antiosteoporotic.
Definition
ChEBI: Bazedoxifene is a phenylindole.
General Description
Bazedoxifene, 1-[[4-[2-(azepan-1-yl)ethoxy]phenyl]methyl]-2-(4-hydroxyphenyl)-3-methylindol-5-ol (Viviant), was declared to be “approvable” bythe FDA in 2007 for the prevention of postmenopausalosteoporosis. As of mid-2009, final approval in the UnitedStates is still pending. Bazedoxifene was approved inEurope in 2009 for the treatment of post–menopausalosteoporosis.
Clinical Use
Bazedoxifene is an indole-based SERM that is under investigation for the treatment and prevention of postmenopausal osteoporosis. It also is being evaluated in combination with Premarin (conjugated estrogens). Bazedoxifene displaces 17β-estradiol from estrogen receptors and has excellent binding affinity for the receptor itself. Unlike raloxifene, this agent does not cause hot flashes at the doses required to have a beneficial effect on bone. In addition, it does not cause uterine or mammary gland stimulation.
Enzyme inhibitor
This potent and selective estrogen receptor modulator, or SERM (FW = 530.65 g/mol; CAS 198481-33-3; Solubility: 00 mM in DMSO), also named 1-[[4-[2- (hexahydro-1H-azepin-1-yl) ethoxy]phenyl]methyl]-2- (4- hydroxyphenyl) -3-methyl-1H-indol-5-ol, selectivity targets the extrogen receptor ERα (IC50 = 26 nM), with weaker action against ERβ (IC50 = 99 nM), inhibiting 17β-estradiol-induced proliferation of MCF-7 cells. Bazedoxifene represents a promising new treatment for osteoporosis, one with a potential for less uterine and vasomotor effects than selective estrogen receptor modulators now used clinically.
target
estrogen receptor
Bazedoxifene Preparation Products And Raw materials
Raw materials
Preparation Products
Bazedoxifene Suppliers
View Lastest Price from Bazedoxifene manufacturers
- Product
- Bazedoxifene 198481-32-2
- Price
- US $85.00-850.00/kg
- Min. Order
- 10kg
- Purity
- 0.99
- Supply Ability
- 20tons
- Release date
- 2023-10-31
- Product
- Bazedoxifene 198481-32-2
- Price
- US $0.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 20 TONS
- Release date
- 2022-11-07
- Product
- Bazedoxifene 198481-32-2
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 98%
- Supply Ability
- 100KG
- Release date
- 2019-09-18