ChemicalBook > CAS DataBase List > Bazedoxifene

Bazedoxifene

Product Name
Bazedoxifene
CAS No.
198481-32-2
Chemical Name
Bazedoxifene
Synonyms
Tse-424;CS-1993;Batoxifene;Bazedoxifen;Bardoxifene;Bazedoxifene;Bazedoxifeno;Unii-Q16tt9C5bk;BAZEDOXIFENE BASE;Bazedoxifene [inn]
CBNumber
CB01458163
Molecular Formula
C30H34N2O3
Formula Weight
470.6
MOL File
198481-32-2.mol
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Bazedoxifene Property

Melting point:
98-102°
Boiling point:
694.4±55.0 °C(Predicted)
Density 
1.19
storage temp. 
Sealed in dry,Store in freezer, under -20°C
solubility 
Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly)
form 
Solid
pka
10.12±0.15(Predicted)
color 
White to Very Dark Beige
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H360May damage fertility or the unborn child

Precautionary statements

P201Obtain special instructions before use.

P202Do not handle until all safety precautions have been read and understood.

P281Use personal protective equipment as required.

P308+P313IF exposed or concerned: Get medical advice/attention.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

TRC
Product number
B129245
Product name
Bazedoxifene
Packaging
25mg
Price
$790
Updated
2021/12/16
ApexBio Technology
Product number
A3232
Product name
Bazedoxifene
Packaging
5mg
Price
$142
Updated
2021/12/16
ApexBio Technology
Product number
A3232
Product name
Bazedoxifene
Packaging
10mg
Price
$249
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
API0024680
Product name
BAZEDOXIFENE
Purity
95.00%
Packaging
5MG
Price
$502.94
Updated
2021/12/16
Ambeed
Product number
A696565
Product name
Bazedoxifene
Purity
98+%
Packaging
5mg
Price
$109
Updated
2021/12/16
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Bazedoxifene Chemical Properties,Usage,Production

Uses

Bazedoxifene is an nonsteroidal selective estrogen receptor modulator (SERM). Bazedoxifene is used as an antiosteoporotic.

Definition

ChEBI: Bazedoxifene is a phenylindole.

General Description

Bazedoxifene, 1-[[4-[2-(azepan-1-yl)ethoxy]phenyl]methyl]-2-(4-hydroxyphenyl)-3-methylindol-5-ol (Viviant), was declared to be “approvable” bythe FDA in 2007 for the prevention of postmenopausalosteoporosis. As of mid-2009, final approval in the UnitedStates is still pending. Bazedoxifene was approved inEurope in 2009 for the treatment of post–menopausalosteoporosis.

Clinical Use

Bazedoxifene is an indole-based SERM that is under investigation for the treatment and prevention of postmenopausal osteoporosis. It also is being evaluated in combination with Premarin (conjugated estrogens). Bazedoxifene displaces 17β-estradiol from estrogen receptors and has excellent binding affinity for the receptor itself. Unlike raloxifene, this agent does not cause hot flashes at the doses required to have a beneficial effect on bone. In addition, it does not cause uterine or mammary gland stimulation.

Enzyme inhibitor

This potent and selective estrogen receptor modulator, or SERM (FW = 530.65 g/mol; CAS 198481-33-3; Solubility: 00 mM in DMSO), also named 1-[[4-[2- (hexahydro-1H-azepin-1-yl) ethoxy]phenyl]methyl]-2- (4- hydroxyphenyl) -3-methyl-1H-indol-5-ol, selectivity targets the extrogen receptor ERα (IC50 = 26 nM), with weaker action against ERβ (IC50 = 99 nM), inhibiting 17β-estradiol-induced proliferation of MCF-7 cells. Bazedoxifene represents a promising new treatment for osteoporosis, one with a potential for less uterine and vasomotor effects than selective estrogen receptor modulators now used clinically.

target

estrogen receptor

Bazedoxifene Preparation Products And Raw materials

Raw materials

Preparation Products

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Bazedoxifene Suppliers

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View Lastest Price from Bazedoxifene manufacturers

Wuhan Senwayer Century Chemical Co.,Ltd
Product
Bazedoxifene 198481-32-2
Price
US $0.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
20 TONS
Release date
2022-11-07
Zibo Hangyu Biotechnology Development Co., Ltd
Product
Bazedoxifene 198481-32-2
Price
US $85.00-850.00/kg
Min. Order
10kg
Purity
0.99
Supply Ability
20tons
Release date
2023-10-31
Career Henan Chemical Co
Product
Bazedoxifene 198481-32-2
Price
US $1.00/KG
Min. Order
1KG
Purity
98%
Supply Ability
100KG
Release date
2019-09-18

198481-32-2, BazedoxifeneRelated Search:

FLAVOXATE Olaparib Indacaterol CETUXIMAB Baclofen VILAZODONE Rivaroxaban Liraglutide Capecitabine Sofosbuvir Dapoxetine 1-[[4-[2-(Hexahydro-1-oxido-1H-azepin-1-yl)ethoxy]phenyl]Methyl]-2-(4-hydroxyphenyl)-3-Methyl-1H-indol-5-ol BAZEDOXIFENE ACETATE 4-[2-(DIMETHYLAMINO)ETHOXY]BENZYLAMINE 1-Ethyl-2-phenylindole Bazedoxifene 1-[4-(2-AZEPAN-1-YL-ETHOXY)-BENZYL]-5-BENZYLOXY-2-(4-BENZYLOXY-PHENYL)-3-METHYL-1H-INDOLE 1,3-DIMETHYL-2-PHENYLINDOLE

  • CS-1993
  • Batoxifene
  • 1-[[4-[2-(azepan-1-yl)ethoxy]phenyl]methyl]-2-(4-hydroxyphenyl)-3-methyl-indol-5-ol
  • 1-((4-(2-Hexahydro-1H-azepin-1-yl)ethoxy)phenyl)methyl)-2-(4-hydroxyphenyl)-3-methyl-1H-indol-5-ol
  • 1H-Indol-5-ol, 1-((4-(2-(hexahydro-1H-azepin-1-yl)ethoxy)phenyl)methyl)-2-(4-hydroxyphenyl)-3-methyl-
  • Bazedoxifene
  • Bazedoxifene [inn]
  • Bazedoxifeno
  • Bazedoxifeno [inn-spanish]
  • Tse-424
  • Unii-Q16tt9C5bk
  • Bazedoxifen
  • BAZEDOXIFENE BASE
  • Bazedoxifene free base
  • 1-[[4-[2-(azepan-1-yl)ethoxy]phenyl]methyl]-2-(4-hydroxyphen...
  • 1-(4-(2-(Azepan-1-yl)ethoxy)benzyl)-2-(4-hydroxyphenyl)-3-methyl-1H-indol-5-ol
  • Bardoxifene
  • 198481-32-2
  • C30H34N2O3
  • Aromatics
  • Heterocycles
  • Intermediates & Fine Chemicals
  • Pharmaceuticals