1H-INDEN-1-ONE, 5-BROMO-6-FLUORO-2,3-DIHYDRO-
- Product Name
- 1H-INDEN-1-ONE, 5-BROMO-6-FLUORO-2,3-DIHYDRO-
- CAS No.
- 866862-25-1
- Chemical Name
- 1H-INDEN-1-ONE, 5-BROMO-6-FLUORO-2,3-DIHYDRO-
- Synonyms
- 5-Bromo-6-fluoro-1-indanone;1H-INDEN-1-ONE, 5-BROMO-6-FLUORO-2,3-DIHYDRO-
- CBNumber
- CB72684878
- Molecular Formula
- C9H6BrFO
- Formula Weight
- 229.05
- MOL File
- 866862-25-1.mol
1H-INDEN-1-ONE, 5-BROMO-6-FLUORO-2,3-DIHYDRO- Property
- Boiling point:
- 301.4±42.0 °C(Predicted)
- Density
- 1.691±0.06 g/cm3(Predicted)
- storage temp.
- Sealed in dry,Room Temperature
- Appearance
- White to yellow Solid
Safety
- HS Code
- 2914790090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P321Specific treatment (see … on this label).
P330Rinse mouth.
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P362Take off contaminated clothing and wash before reuse.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- PC908171
- Product name
- 5-Bromo-6-fluoro-2,3-dihydro-1H-inden-1-one
- Purity
- 95%
- Packaging
- 250mg
- Price
- $345
- Updated
- 2021/12/16
- Product number
- PC908171
- Product name
- 5-Bromo-6-fluoro-2,3-dihydro-1H-inden-1-one
- Purity
- 95%
- Packaging
- 1g
- Price
- $765
- Updated
- 2021/12/16
- Product number
- 9563DT
- Product name
- 5-Bromo-6-fluoro-2,3-dihydro-1H-inden-1-one
- Packaging
- 1g
- Price
- $1302
- Updated
- 2021/12/16
- Product number
- JR6-L1725
- Product name
- 1H-Inden-1-one,5-bromo-6-fluoro-2,3-dihydro-
- Purity
- 96%
- Packaging
- 5g
- Price
- $780
- Updated
- 2021/12/16
- Product number
- A104440
- Product name
- 5-Bromo-6-fluoro-2,3-dihydro-1H-inden-1-one
- Purity
- 95+%
- Packaging
- 100mg
- Price
- $133
- Updated
- 2021/12/16
1H-INDEN-1-ONE, 5-BROMO-6-FLUORO-2,3-DIHYDRO- Chemical Properties,Usage,Production
Synthesis
866862-24-0
866862-25-1
The general procedure for the synthesis of 5-bromo-6-fluoro-2,3-dihydro-1H-inden-1-one using 3-(3-bromo-4-fluorophenyl)propionic acid as starting material was as follows: 3-(3-bromo-4-fluorophenyl)propionic acid (3.5 g, 14.2 mmol) was dissolved in a solvent mixture of dichloromethane (25 mL) and N,N-dimethylformamide (0.5 mL) at room temperature. Oxalyl chloride (7.2 g, 56.7 mmol) was then added. The reaction mixture was continued to be stirred for 30 min before the solvent was removed by distillation under reduced pressure. The resulting residue was redissolved in dichloromethane (50 mL) and added slowly and dropwise to a refluxing suspension of pre-prepared aluminum trichloride (7.6 g, 56.7 mmol) in dichloromethane (200 mL). The reaction mixture was kept under reflux conditions for 90 min, followed by pouring into an ice/concentrated hydrochloric acid mixture to quench the reaction. Extraction was carried out with dichloromethane (3 x 200 mL) and concentrated under reduced pressure after combining the organic phases. Finally, the residue was purified by column chromatography (eluent 25% petroleum ether solution of ethyl acetate) to afford the target compound 5-bromo-6-fluoro-2,3-dihydro-1H-inden-1-one as a light yellow solid (2.1 g, 68% yield). Mass spectrometry analysis (ESI) showed that the calculated value of [M+H]+ was 229 (C9H6BrFO) and the measured value was 229.
References
[1] Patent: WO2014/74422, 2014, A1. Location in patent: Paragraph 00181
1H-INDEN-1-ONE, 5-BROMO-6-FLUORO-2,3-DIHYDRO- Preparation Products And Raw materials
Raw materials
Preparation Products
1H-INDEN-1-ONE, 5-BROMO-6-FLUORO-2,3-DIHYDRO- Suppliers
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