BI 6015
- Product Name
- BI 6015
- CAS No.
- 93987-29-2
- Chemical Name
- BI 6015
- Synonyms
- B16015;BI 6015;2-Methyl-1-[(2-methyl-5-nitrophenyl)sulfonyl]-1H-benzimidazole;2-Methyl-1-(2-methyl-5-nitrophenylsulfonyl)-1H-benzo[d]imidazole;1H-Benzimidazole, 2-methyl-1-[(2-methyl-5-nitrophenyl)sulfonyl]-;inhibit,promoter,HNF4α,factor,hepatocyte,Inhibitor,diabetes,insulin,BI-6015,BI6015,nuclear,cancer,BI 6015
- CBNumber
- CB72695661
- Molecular Formula
- C15H13N3O4S
- Formula Weight
- 331.35
- MOL File
- 93987-29-2.mol
BI 6015 Property
- Boiling point:
- 570.6±60.0 °C(Predicted)
- Density
- 1.45±0.1 g/cm3(Predicted)
- storage temp.
- +2C to +8C
- solubility
- Soluble in DMSO (up to 25 mg/ml) or in Ethanol (up to 10 mg/ml).
- form
- Beige powder
- pka
- 0.88±0.10(Predicted)
- color
- Tan
- Stability:
- Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 2 months.
N-Bromosuccinimide Price
- Product number
- 375240
- Product name
- HNF4 Antagonist, BI6015 - CAS 93987-29-2 - Calbiochem<br />The HNF4 Antagonist, BI6, also referenced under CAS 93987-29-2, controls the biological activity of HNF4.
- Packaging
- 25mg
- Price
- $259
- Updated
- 2024/03/01
- Product number
- 12032
- Product name
- BI6015
- Purity
- ≥95%
- Packaging
- 5mg
- Price
- $48
- Updated
- 2024/03/01
- Product number
- 12032
- Product name
- BI6015
- Purity
- ≥95%
- Packaging
- 10mg
- Price
- $86
- Updated
- 2024/03/01
- Product number
- 12032
- Product name
- BI6015
- Purity
- ≥95%
- Packaging
- 50mg
- Price
- $360
- Updated
- 2024/03/01
- Product number
- 4641
- Product name
- BI6015
- Purity
- ≥98%(HPLC)
- Packaging
- 50
- Price
- $828
- Updated
- 2021/12/16
BI 6015 Chemical Properties,Usage,Production
Description
BI-6015 (93987-29-2) is a hepatocyte nuclear factor 4α (HNF4α) antagonist. HNF4α is a central regulator of gene expression in cell types that play a central role in metabolic homeostasis.1 BI-6015 binds to HNF4α with high affinity and modulates the expression of known target genes. It was shown to be selectively cytotoxic to cancer cell lines in vitro and in vivo however in vivo potency was limited by suboptimal pharmacokinetics.2 BI-6015 represents the first small molecule tool for pharmacologic modulation of HNF4α activity.2 Cell permeable.
Uses
BI 6015 is a known HNF4α antagonist that represses the expression of known HNF4α target genes. Studies have shown that BI6015 are also capable of exhibiting selective cytotoxic activities against numerous tumor cell lines.
storage
Store at -20°C
References
1) Wang et al. (2000), Hepatocyte Nuclear Factor 4α Regulates the Expression of Pancreatic β-Cell Genes Implicated in Glucose Metabolism and Nutrient-induced Insulin Secretion; J. Biol. Chem., 275 35953 2) Kiselyuk et al. (2012), HNF4α antagonists discovered by a high-throughput screen for modulators of the human insulin promotor; Chem. Biol., 19 806
BI 6015 Preparation Products And Raw materials
Raw materials
Preparation Products
BI 6015 Suppliers
- Tel
- --
- Fax
- --
- customerservice@tocris.co.uk
- Country
- United Kingdom
- ProdList
- 5726
- Advantage
- 77