ChemicalBook > CAS DataBase List > 2-Bromo-2-(2'-chlorophenyl) acetic acid

2-Bromo-2-(2'-chlorophenyl) acetic acid

Product Name
2-Bromo-2-(2'-chlorophenyl) acetic acid
CAS No.
29270-30-2
Chemical Name
2-Bromo-2-(2'-chlorophenyl) acetic acid
Synonyms
2-Bromo-2-(2'-chL;α-Bromo-2-chlorobenzeneacetic;(2-Chlorophenyl)broMoacetic Acid;à-bromo-2-chlorophenylacetic acid;A-BROMO 2-CHLOROPHENYLACETIC ACID;α-Bromo-2-chlorobenzeneacetic acid;A-BROMO-2-CHLOROBENZENEACETIC ACID;Benzeneacetic acid, a-broMo-2-chloro-;α-Bromo-2-chlorophenylacetic Acid >Benzeneacetic acid, α-bromo-2-chloro-
CBNumber
CB7270235
Molecular Formula
C8H6BrClO2
Formula Weight
249.49
MOL File
29270-30-2.mol
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2-Bromo-2-(2'-chlorophenyl) acetic acid Property

Melting point:
105-108°C
Boiling point:
316.7±27.0 °C(Predicted)
Density 
1.747±0.06 g/cm3(Predicted)
storage temp. 
Inert atmosphere,Room Temperature
solubility 
Chloroform, Methanol
form 
Solid
pka
2.24±0.10(Predicted)
color 
White to Off-White
CAS DataBase Reference
29270-30-2(CAS DataBase Reference)
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Safety

Hazard Codes 
C,Xi
Risk Statements 
36/37/38
Safety Statements 
24/25
RIDADR 
UN3261
WGK Germany 
3
Hazard Note 
Corrosive
HazardClass 
8
PackingGroup 
II
HS Code 
2916399090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
722235
Product name
α-Bromo-2-chlorophenylacetic acid
Purity
97%
Packaging
25g
Price
$37.9
Updated
2023/06/20
TCI Chemical
Product number
B2950
Product name
alpha-Bromo-2-chlorophenylacetic Acid
Purity
>98.0%(GC)(T)
Packaging
25g
Price
$25
Updated
2025/07/31
TRC
Product number
B682255
Product name
2-Bromo-2-(2-chlorophenyl)aceticAcid
Packaging
250g
Price
$1190
Updated
2021/12/16
Matrix Scientific
Product number
070858
Product name
2-Bromo-2-(2'-chlorophenyl) acetic acid
Purity
98%
Packaging
25g
Price
$24
Updated
2021/12/16
Apolloscientific
Product number
OR11047
Product name
alpha-Bromo-2-chlorophenylacetic Acid
Packaging
25g
Price
$25
Updated
2021/12/16
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2-Bromo-2-(2'-chlorophenyl) acetic acid Chemical Properties,Usage,Production

Chemical Properties

White to Off-White Solid

Uses

2-Bromo-2-(2-chlorophenyl)acetic Acid is used as an intermediate in the preparation of biologically active compounds such as the antithrombotic Clopidogrel (C587250).

Synthesis

2444-36-2

29270-30-2

Under nitrogen protection, 2.0 g (11.76 mmol) of o-chlorophenylacetic acid (Aldrich) and 2.1 g (11.76 mmol) of N-bromosuccinimide (NBS, Aldrich) were dissolved in 60 mL of carbon tetrachloride (CCI4). Subsequently, 569 mg (2.35 mmol) of benzoyl peroxide (Fluka) was added to the solution. The reaction mixture was stirred at 80°C for 5 hours. After completion of the reaction, the reaction mixture was filtered and the filtrate was concentrated under reduced pressure. The crude product was purified by fast chromatography using a 50 g silica gel column with a solvent mixture of dichloromethane (DCM) and ethyl acetate (AcOEt) (10:0 to 5:5 gradient) as eluent. After removing the solvent under reduced pressure, 2-bromo-o chlorophenylacetic acid (1.7 g, 48% yield) was obtained.1H-NMR (400 MHz, CDCl3) data were as follows: δ 5.95 (1H, s), 7.35 (3H, m), 7.80 (1H, d).

References

[1] Patent: WO2008/148853, 2008, A1. Location in patent: Page/Page column 51
[2] Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 2008, vol. 47, # 1, p. 97 - 105
[3] Journal of Heterocyclic Chemistry, 2017, vol. 54, # 2, p. 1355 - 1360
[4] Patent: CN103450005, 2016, B. Location in patent: Paragraph 0051-0053

2-Bromo-2-(2'-chlorophenyl) acetic acid Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from 2-Bromo-2-(2'-chlorophenyl) acetic acid manufacturers

Career Henan Chemical Co
Product
2-Bromo-2-(2'-chlorophenyl) acetic acid 29270-30-2
Price
US $1.00/g
Min. Order
1g
Purity
99%
Supply Ability
10000KGS
Release date
2019-12-26

29270-30-2, 2-Bromo-2-(2'-chlorophenyl) acetic acidRelated Search:

Ethyl 2-(Chlorosulfonyl)acetate Ethyl bromodifluoroacetate Ethyl bromoacetate 2-Chlorophenylacetic acid Ethyl acetate Methyl bromoacetate 4-Chlorophenylacetic acid 3-Bromoanisole Bromoacetic acid α-Lipoic Acid tert-Butyl bromoacetate α-Bromo-2-(2-chlorophenyl)acetic acid Chloroacetic acid Acetic anhydride Acetic acid 2-Bromo-2-(2'-chlorophenyl) acetic acid α-Bromo-p-chlorophenylacetic acid a-Bromo- 2-(2'-chlorophenyl)acetic acid

  • A-BROMO 2-CHLOROPHENYLACETIC ACID
  • alpha-Bromo-2-chlorobenzeneacetic acid
  • à-bromo-2-chlorophenylacetic acid
  • A-BROMO-2-CHLOROBENZENEACETIC ACID
  • L-ALPHA-BROMO-(2-CHLORO)PHENYL ACETIC ACID
  • α-Bromo-2-chlorobenzeneacetic acid
  • ɑ-Bromo-2-chlorophenylacetic acid, 98%
  • α-Bromo-2-chlorobenzeneacetic
  • (2-Chlorophenyl)broMoacetic Acid
  • Benzeneacetic acid, a-broMo-2-chloro-
  • Benzeneacetic acid, .alpha.-bromo-2-chloro-
  • α-Bromo-2-chlorophenylacetic Acid &gt
  • 2-Bromo-2-(2'-chL
  • Benzeneacetic acid, α-bromo-2-chloro-
  • Alpha-Bromo-2-ChlrophenyIaceticacid (and its Methyl ester)
  • 2-Bromo-2-(2'-chlorophenyl) acetic acid
  • 29270-30-2
  • 141-10-9
  • C8H6BrClO2
  • Pharmaceutical Intermediates