2-Bromo-2-(2'-chlorophenyl) acetic acid
- Product Name
- 2-Bromo-2-(2'-chlorophenyl) acetic acid
- CAS No.
- 29270-30-2
- Chemical Name
- 2-Bromo-2-(2'-chlorophenyl) acetic acid
- Synonyms
- 2-Bromo-2-(2'-chL;α-Bromo-2-chlorobenzeneacetic;(2-Chlorophenyl)broMoacetic Acid;à-bromo-2-chlorophenylacetic acid;A-BROMO 2-CHLOROPHENYLACETIC ACID;α-Bromo-2-chlorobenzeneacetic acid;A-BROMO-2-CHLOROBENZENEACETIC ACID;Benzeneacetic acid, a-broMo-2-chloro-;α-Bromo-2-chlorophenylacetic Acid >Benzeneacetic acid, α-bromo-2-chloro-
- CBNumber
- CB7270235
- Molecular Formula
- C8H6BrClO2
- Formula Weight
- 249.49
- MOL File
- 29270-30-2.mol
2-Bromo-2-(2'-chlorophenyl) acetic acid Property
- Melting point:
- 105-108°C
- Boiling point:
- 316.7±27.0 °C(Predicted)
- Density
- 1.747±0.06 g/cm3(Predicted)
- storage temp.
- Inert atmosphere,Room Temperature
- solubility
- Chloroform, Methanol
- form
- Solid
- pka
- 2.24±0.10(Predicted)
- color
- White to Off-White
- CAS DataBase Reference
- 29270-30-2(CAS DataBase Reference)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 722235
- Product name
- α-Bromo-2-chlorophenylacetic acid
- Purity
- 97%
- Packaging
- 25g
- Price
- $37.9
- Updated
- 2023/06/20
- Product number
- B2950
- Product name
- alpha-Bromo-2-chlorophenylacetic Acid
- Purity
- >98.0%(GC)(T)
- Packaging
- 25g
- Price
- $25
- Updated
- 2025/07/31
- Product number
- B682255
- Product name
- 2-Bromo-2-(2-chlorophenyl)aceticAcid
- Packaging
- 250g
- Price
- $1190
- Updated
- 2021/12/16
- Product number
- 54864
- Product name
- 2-Bromo-2-(2-chlorophenyl)aceticAcid
- Packaging
- 250g
- Price
- $2200
- Updated
- 2021/12/16
- Product number
- 070858
- Product name
- 2-Bromo-2-(2'-chlorophenyl) acetic acid
- Purity
- 98%
- Packaging
- 500g
- Price
- $247
- Updated
- 2021/12/16
2-Bromo-2-(2'-chlorophenyl) acetic acid Chemical Properties,Usage,Production
Chemical Properties
White to Off-White Solid
Uses
2-Bromo-2-(2-chlorophenyl)acetic Acid is used as an intermediate in the preparation of biologically active compounds such as the antithrombotic Clopidogrel (C587250).
Synthesis
2444-36-2
29270-30-2
Under nitrogen protection, 2.0 g (11.76 mmol) of o-chlorophenylacetic acid (Aldrich) and 2.1 g (11.76 mmol) of N-bromosuccinimide (NBS, Aldrich) were dissolved in 60 mL of carbon tetrachloride (CCI4). Subsequently, 569 mg (2.35 mmol) of benzoyl peroxide (Fluka) was added to the solution. The reaction mixture was stirred at 80°C for 5 hours. After completion of the reaction, the reaction mixture was filtered and the filtrate was concentrated under reduced pressure. The crude product was purified by fast chromatography using a 50 g silica gel column with a solvent mixture of dichloromethane (DCM) and ethyl acetate (AcOEt) (10:0 to 5:5 gradient) as eluent. After removing the solvent under reduced pressure, 2-bromo-o chlorophenylacetic acid (1.7 g, 48% yield) was obtained.1H-NMR (400 MHz, CDCl3) data were as follows: δ 5.95 (1H, s), 7.35 (3H, m), 7.80 (1H, d).
References
[1] Patent: WO2008/148853, 2008, A1. Location in patent: Page/Page column 51
[2] Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 2008, vol. 47, # 1, p. 97 - 105
[3] Journal of Heterocyclic Chemistry, 2017, vol. 54, # 2, p. 1355 - 1360
[4] Patent: CN103450005, 2016, B. Location in patent: Paragraph 0051-0053
2-Bromo-2-(2'-chlorophenyl) acetic acid Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 2-Bromo-2-(2'-chlorophenyl) acetic acid manufacturers
- Product
- 2-Bromo-2-(2'-chlorophenyl) acetic acid 29270-30-2
- Price
- US $1.00/g
- Min. Order
- 1g
- Purity
- 99%
- Supply Ability
- 10000KGS
- Release date
- 2019-12-26