ChemicalBook > CAS DataBase List > EzetiMibe-d4

EzetiMibe-d4

Product Name
EzetiMibe-d4
CAS No.
1093659-89-2
Chemical Name
EzetiMibe-d4
Synonyms
D4-Ezetimibe;Ezetimibe-d4-1;[2H4]-Ezetimibe;Ezetimibe Impurity 119;Ezetimibe D4 (4-Fluorophenyl-2,3,5,6-d4);(3R,4S)-1-(4-Fluorophenyl)-3-((S)-3-(4-fluorophenyl-2,3,5,6-d4)-3-hydroxypropyl)-4-(4-hydroxyphenyl)azetidin-2-one;(3R,4S)-3-[(3S)-3-[4-fluoro(2,3,5,6-2H?)phenyl]-3-hydroxypropyl]-1-(4-fluorophenyl)-4-(4-hydroxyphenyl)azetidin-2-one;(3R,4S)-1-(4-fluorophenyl)-4-(4-hydroxyphenyl)-3-[(3S)-3-hydroxy-3-(2,3,5,6-tetradeuterio-4-fluorophenyl)propyl]azetidin-2-one;Ezetimibe D4Q: What is Ezetimibe D4 Q: What is the CAS Number of Ezetimibe D4 Q: What is the storage condition of Ezetimibe D4
CBNumber
CB72710005
Molecular Formula
C24H21F2NO3
Formula Weight
409.43
MOL File
1093659-89-2.mol
More
Less

EzetiMibe-d4 Property

storage temp. 
Store at -20°C
solubility 
DMF: Soluble; DMSO: Soluble; Ethanol: Soluble; Methanol: Soluble
form 
A solid
color 
White to off-white
More
Less

Hazard and Precautionary Statements (GHS)

More
Less

N-Bromosuccinimide Price

Cayman Chemical
Product number
25044
Product name
Ezetimibe-d4
Purity
≥99% deuterated forms (d1-d4)
Packaging
1mg
Price
$480
Updated
2024/03/01
TRC
Product number
E975003
Product name
Ezetimibe-d4
Packaging
1mg
Price
$275
Updated
2021/12/16
AK Scientific
Product number
2934DC
Product name
(3R,4S)-1-(4-Fluorophenyl)-4-(4-hydroxyphenyl)-3-[(3S)-3-hydroxy-3-(2,3,5,6-tetradeuterio-4-fluorophenyl)propyl]azetidin-2-one
Packaging
1mg
Price
$633
Updated
2021/12/16
More
Less

EzetiMibe-d4 Chemical Properties,Usage,Production

Description

Ezetimibe-d4 is intended for use as an internal standard for the quantification of ezetimibe by GC- or LC-MS. Ezetimibe inhibits intestinal cholesterol absorption by preventing cholesterol uptake by the Niemann-Pick C1-like 1 (NPC1L1) protein, a cholesterol transporter located in the apical membrane of enterocytes. Upon oral administration ezetimibe undergoes rapid glucuronidation in the intestine where its glucuronide binds NPC1L1. Ezetimibe exhibits ED50 values of 0.0005-0.05 mg/kg in various animal models, selectively blocking cholesterol absorption without inhibiting pancreatic lipolytic enzyme activities in the intestinal lumen, affecting bile acid micelle solubilization of cholesterol, or interfering with the absorption of triglycerides, fatty acids, or bile acids.

Uses

Ezetimibe-d4 is the labeled analogue of Ezetimibe (E975000), an antihyperlipoproteinemic. A cholesterol absorption inhibitor.

References

[1] WANG D Q H. Regulation of intestinal cholesterol absorption.[J]. Annual review of physiology, 2007, 69: 221-248. DOI: 10.1146/annurev.physiol.69.031905.160725
[2] MARGARITA GARCIA-CALVO. The target of ezetimibe is Niemann-Pick C1-Like 1 (NPC1L1).[J]. Proceedings of the National Academy of Sciences of the United States of America, 2005: 8132-8137. DOI: 10.1073/pnas.0500269102
[3] THOMAS SUDHOP K von B. Cholesterol absorption inhibitors for the treatment of hypercholesterolaemia.[J]. Drugs, 2002, 62 16: 2333-2347. DOI: 10.2165/00003495-200262160-00002

EzetiMibe-d4 Preparation Products And Raw materials

Raw materials

Preparation Products

More
Less

EzetiMibe-d4 Suppliers

China 30 India 3 United States 3 Global 36
J & K SCIENTIFIC LTD.
Tel
18210857532; 18210857532
Fax
86-10-82849933
Email
jkinfo@jkchemical.com
Country
China
ProdList
96815
Advantage
76
Chemsky（shanghai）International Co.,Ltd.
Tel
021-50135380
Email
shchemsky@sina.com
Country
China
ProdList
32321
Advantage
50
Cato Research Chemicals Inc.
Tel
020-81960175
Fax
+1-541-2553641
Email
min.he@cato-chem.com
Country
China
ProdList
1955
Advantage
55
ChemStrong Scientific Co.,Ltd
Tel
0755-0755-66853366 13670046396
Fax
0755-28363542
Email
sales@chem-strong.com
Country
China
ProdList
18333
Advantage
56
Artis Biotech Co. Ltd.
Tel
028-67271278 18628360895
Fax
0575-89298961
Email
sales@artisbio.com
Country
China
ProdList
1960
Advantage
58
Shanghai EFE Biological Technology Co., Ltd.
Tel
021-65675885 18964387627
Fax
021-65675885
Email
info@efebio.com
Country
China
ProdList
9803
Advantage
58
Chengdu Novel Biomedical Co., Ltd.
Tel
028-85255396 18302801538
Fax
028-85255396
Email
cdnovell@163.com
Country
China
ProdList
2389
Advantage
58
Shenzhen Polymeri Biochemical Technology Co., Ltd.
Tel
+86-400-002-6226 +86-13028896684;
Email
sales@rrkchem.com
Country
China
ProdList
57422
Advantage
58
ChemeGen(Shanghai) Biotechnology Co.,Ltd.
Tel
18818260767
Fax
QQ 3610331285
Email
sales@chemegen.com
Country
China
ProdList
11218
Advantage
58
Nanjing wangzhixing Pharmaceutical Technology Co., Ltd
Tel
18569809817
Fax
025-85722793
Email
2208093734@qq.com
Country
China
ProdList
3978
Advantage
58
Hubei Xinyang Medical Technology Co., Ltd
Tel
15347293736
Fax
QQ：2853117752
Email
2853117764@yongstandards.com
Country
China
ProdList
9997
Advantage
58
Energy Chemical
Tel
021-58432009 400-005-6266
Fax
021-58436166
Email
marketing1@energy-chemical.com
Country
China
ProdList
44894
Advantage
58
QUALITY CONTROL SOLUTIONS LTD.
Tel
+86-0755-66853366 +86-13670046396
Email
export03@qcsrm.com
Country
China
ProdList
24342
Advantage
58
Bide Pharmatech Ltd.
Tel
400-1647117 13681763483
Email
product02@bidepharm.com
Country
China
ProdList
59936
Advantage
58
Shanghai Moqi Biological Technology Co., LTD
Tel
021-38218169 13681877033
Email
2702713455@qq.com
Country
China
ProdList
9997
Advantage
58
LGC Science (Shanghai) Ltd.
Tel
17717235263
Email
cindy.yang@lgcgroup.com
Country
China
ProdList
18003
Advantage
58
Shanghai isotope chemical co.,ltd
Tel
021-51600108 13062666369
Email
sales@isotopechem.com
Country
China
ProdList
5000
Advantage
58
Shanghai?Medlife?Pharm-Tech?Co.,?Ltd
Tel
021-59167510 18117107507
Email
vip@med-life.cn
Country
China
ProdList
5002
Advantage
58
guoyungurui
Tel
18162595016; 18162595016
Email
3287908757@qq.com
Country
China
ProdList
10335
Advantage
58
Nanjing Shizhou Biology Technology Co.,Ltd
Tel
17301488900
Fax
025-85560043
Email
judy.xia@synzest.com
Country
China
ProdList
12582
Advantage
58
Guangzhou Zhenlin Pharmaceutical Technology Co., Ltd
Tel
020-18102736 18102736234
Email
LK@zlstandards.com
Country
China
ProdList
8206
Advantage
58
Nantong Hanfang Biotechnology Co. , Ltd.
Tel
hanfangpharma@126.com; 18616537568
Email
hanfangpharma@126.com
Country
China
ProdList
29965
Advantage
58
Cato Research Chemicals Inc.
Tel
020-81960175-877 18933936954
Email
2853283383@qq.com
Country
China
ProdList
11421
Advantage
58
TLC Pharmaceutical Standards Ltd.
Tel
18012923235; 18012923235
Email
chinasales04@tlcstandards.com.cn
Country
China
ProdList
7974
Advantage
58
Tanmo Quality Inspection Technology Co., Ltd.
Tel
4008-099-669
Email
23419001name@qq.com
Country
CHINA
ProdList
6043
Advantage
58
Cayman Chemical Company
Tel
800-364-9897
Email
sales@caymanchem.com
Country
China
ProdList
6838
Advantage
58
Biosynth Biological Technology (Suzhou) Co Ltd
Tel
51288865780
Email
sales@biosynth.com
Country
China
ProdList
6051
Advantage
58
Santa Cruz Biotechnology Inc
Tel
021-60936350
Email
scbt@scbt.com
Country
China
ProdList
6594
Advantage
58
ShangHai ZskBio CO., LTD
Tel
021-58056897 15399714481
Email
info@zsklab.com
Country
China
ProdList
7190
Advantage
58
Shanghai Hao Zhun Biological Technology Co., Ltd.
Tel
--
Fax
--
Email
info@zzsrm.com
Country
CHINA
ProdList
6650
Advantage
58

1093659-89-2, EzetiMibe-d4Related Search:

Ezetimibe (3R,4S)-1-(4-fluorophenyl)-3-((S)-3-hydroxy-3-(p-tolyl)propyl)-4-(4-hydroxyphenyl)azetidin-2-one EzetiMibe Fluoro IsoMer EZETIMIBE PHENOXY GLUCURONIDE (3S,4R)-1-(4-fluorophenyl)-3-((S)-3-(4-fluorophenyl)-3-hydroxypropyl)-4-(4-hydroxyphenyl)azetidin-2-one 3-[5-(1,5-Dioxo-5-(p-fluophenylpentyl]-4R-phenyl-2-oxazolidinone (3R,4S)-1-(4-Fluorophenyl)-2-oxo-4-[4-(benzyloxy)phenyl]-3-azetidinepropanoic acid N,N'-Diisopropylcarbodiimide (3R,4S)-1-(3-fluorophenyl)-3-((S)-3-(4-fluorophenyl)-3-hydroxypropyl)-4-(4-hydroxyphenyl)azetidin-2-one Ezetimibe Impurity 33 (S)-(+)-4-Phenyl-2-oxazolidinone 4-[[(4-Fluorophenyl)imino]methyl]-phenol (3R,4S)-1-(4-chlorophenyl)-3-((S)-3-(4-fluorophenyl)-3-hydroxypropyl)-4-(4-hydroxyphenyl)azetidin-2-one EzetiMibe Dehydoxy IMpurity Ezetimibe-13C6 (4S)-3-[5-(4-Fluorophenyl)-1,5-dioxopenyl]-4-phenyl-2-oxazolidinone N-(4-(Benzyloxy)benzylidene)-4-fluoroaniline (R)-3-((S)-5-(4-fluorophenyl)-5-hydroxypentanoyl)-4-phenyloxazolidin-2-one

  • (3R,4S)-1-(4-fluorophenyl)-4-(4-hydroxyphenyl)-3-[(3S)-3-hydroxy-3-(2,3,5,6-tetradeuterio-4-fluorophenyl)propyl]azetidin-2-one
  • [2H4]-Ezetimibe
  • Ezetimibe Impurity 119
  • Ezetimibe D4Q: What is Ezetimibe D4 Q: What is the CAS Number of Ezetimibe D4 Q: What is the storage condition of Ezetimibe D4
  • Ezetimibe-d4-1
  • Ezetimibe D4 (4-Fluorophenyl-2,3,5,6-d4)
  • (3R,4S)-1-(4-Fluorophenyl)-3-((S)-3-(4-fluorophenyl-2,3,5,6-d4)-3-hydroxypropyl)-4-(4-hydroxyphenyl)azetidin-2-one
  • (3R,4S)-3-[(3S)-3-[4-fluoro(2,3,5,6-2H?)phenyl]-3-hydroxypropyl]-1-(4-fluorophenyl)-4-(4-hydroxyphenyl)azetidin-2-one
  • D4-Ezetimibe
  • 1093659-89-2