2-chloro-5-(2-fluorophenyl)-1H-pyrrole-3-carbonitrile

Product Name: 2-chloro-5-(2-fluorophenyl)-1H-pyrrole-3-carbonitrile
CAS No.: 1240948-72-4
Chemical Name: 2-chloro-5-(2-fluorophenyl)-1H-pyrrole-3-carbonitrile
Synonyms: Vonoprazan-3;Vonoprazan-024;TAK438 Impurity 32;Vonolazan impurity 3;Vonoprazan Impurity Ⅶ;Vonoprazan Impurity 33;TAK438 Intermediate 3;Vonoprazan Fumarate impurity G;Voronozan initiator 1 impurity I;2-chloro-5-(2-fluorophenyl)-1H-pyrrole-3-carbonitrile
CBNumber: CB72722688
Molecular Formula: C11H6ClFN2
Formula Weight: 220.63
MOL File: 1240948-72-4.mol

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2-chloro-5-(2-fluorophenyl)-1H-pyrrole-3-carbonitrile Property

Boiling point:: 403.0±45.0 °C(Predicted)
Density: 1.41±0.1 g/cm3(Predicted)
storage temp.: 2-8°C
pka: 12.88±0.50(Predicted)

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Chemenu

Product number: CM198987
Product name: 2-chloro-5-(2-fluorophenyl)-1H-pyrrole-3-carbonitrile
Purity: 95%
Packaging: 1g
Price: $580
Updated: 2021/12/16

Crysdot

Product number: CD11318402
Product name: 2-Chloro-5-(2-fluorophenyl)-1H-pyrrole-3-carbonitrile
Purity: 95+%
Packaging: 1g
Price: $620
Updated: 2021/12/16

Alichem

Product number: 1240948724
Product name: 2-Chloro-5-(2-fluorophenyl)-1H-pyrrole-3-carbonitrile
Packaging: 1g
Price: $653
Updated: 2021/12/16

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2-chloro-5-(2-fluorophenyl)-1H-pyrrole-3-carbonitrile Chemical Properties,Usage,Production

Description

2-chloro-5-(2-fluorophenyl)-1H-pyrrole-3-carbonitrile is an important pharmaceutical intermediate. It can be used in the preparation of vorexanol fumarate and vonoprazan, and can also be used as a chemical raw material for the synthesis of other organic compounds.

Uses

2-Chloro-5-(2-fluorophenyl)-1H-pyrrole-3-carbonitrile (Vonoprazan Impurity 33) is an impurity of Vonoprazan, a potassium-competitive acid blocker (P-CAB) that suppresses gastric acid secretion.

Synthesis

2-chloro-5-(2-fluorophenyl)-1H-pyrrole-3-carbonitrile is synthesised using 2-[2-(2-fluorophenyl)-2-oxoethyl]malononitrile as raw material by chemical reaction. The specific synthesis steps are as follows:
2 g of the intermediate III-1 was dissolved in 40 ml of a solution of hydrochloric acid in ethyl acetate, and the mixture was stirred at room temperature overnight. After the reaction is completed, the solvent is distilled off under reduced pressure to give the compound of 2-chloro-5-(2-fluorophenyl)-1H-pyrrole-3-carbonitrile, 2.1 g of a white solid with a yield of 96%.

2-chloro-5-(2-fluorophenyl)-1H-pyrrole-3-carbonitrile Preparation Products And Raw materials

Raw materials

Preparation Products

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2-chloro-5-(2-fluorophenyl)-1H-pyrrole-3-carbonitrile Suppliers

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View Lastest Price from 2-chloro-5-(2-fluorophenyl)-1H-pyrrole-3-carbonitrile manufacturers

Henan Aochuang Chemical Co.,Ltd.

Product: 2-chloro-5-(2-fluorophenyl)-1H-pyrrole-3-carbonitrile 1240948-72-4
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: 1Ton
Release date: 2022-09-30

Zhuozhou Wenxi import and Export Co., Ltd

Product: 2-chloro-5-(2-fluorophenyl)-1H-pyrrole-3-carbonitrile 1240948-72-4
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-07-10

Zhuozhou Wenxi import and Export Co., Ltd

Product: 2-chloro-5-(2-fluorophenyl)-1H-pyrrole-3-carbonitrile 1240948-72-4
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-07-09

1240948-72-4, 2-chloro-5-(2-fluorophenyl)-1H-pyrrole-3-carbonitrileRelated Search:

Vonoprazan Fumarate impurity (5-(2-fluorophenyl)-1-(pyridin-3-ylsulfonyl)-1H-pyrrol-3-yl) methanol 4-Pyridinesulphonic acid 5-(2-Fluorophenyl)-1H-pyrrole-3-carbaldehyde 1H-Pyrrole-3-carbonitrile,5-(2-fluorophenyl)-1-(3-pyridinylsulfonyl)- PYRIDINE-4-SULFONYL CHLORIDE PYRIDINE-2-SULFONIC ACID 3-N,N-dimethylsulfamoylpyridine 1H-Pyrrole-3-carboxylic acid, 5-(2-fluorophenyl)-, ethyl ester 5-(4-fluorophenyl)-1H-pyrrole-3-carbonitrile 1-(5-(2-fluorophenyl)-1-(pyridin-2-ylsulfonyl)-1H-pyrrol-3-yl)-N- methylmethanamine fumarate 5-chloropyridine-3-sulfonyl chloride 1-methylpyridin-1-ium-4-sulfonate 1-(5-(2-fluorophenyl)-1H-pyrrol-3-yl)-N-methylmethanamine 5-(2-Fluorophenyl)-1-(pyridin-3-ylsulfonyl)-1H-pyrrole-3-carbaldehyde 5-(2-fluorophenyl)-1H-pyrrole-3-carbonitrile 1H-PYRROLE-3-METHANOL, 5-(2-FLUOROPHENYL)- (Z)-N-((5-(2-fluorophenyl)-1-(pyridin-3-ylsulfonyl)-1H-pyrrol-3-yl)methylene)methanamine oxide

2-chloro-5-(2-fluorophenyl)-1H-pyrrole-3-carbonitrile

1H-Pyrrole-3-carbonitrile,2-chloro-5-(2-fluorophenyl)-

Vonoprazan Fumarate impurity G

Vonoprazan Impurity 33

Vonoprazan Impurity Ⅶ

Vonoprazan-024

TAK438 Impurity 32

Vonoprazan impurity 28/2-chloro-5-(2-fluorophenyl)-1H-pyrrole-3-carbonitrile

Vonoprazan impurity SM2-A: 2-chloro-5- (2-fluorophenyl) -1H-pyrrole-3-carbonitrile

Vonoprazan-3

Voronozan initiator 1 impurity I

2-chloro-5-(2-fluorophenyl)-1H-pyrrole-3-carbonitrile (Vonoprazan Impurity）

TAK438 Intermediate 3

Vonolazan impurity 3

1240948-72-4