Molidustat(BAY 85-3934)

Product Name: Molidustat(BAY 85-3934)
CAS No.: 1154028-82-6
Chemical Name: Molidustat(BAY 85-3934)
Synonyms: CS-1728;Somatoprim;MOLIDUSTAT;BAY 85-3934;Molidustat(BAY 85-3934);BAY 85-3934;BAY-85-3934;2-(6-morpholin-4-ylpyrimidin-4-yl)-4-(triazol-1-yl)-1H-pyrazol-3-one;2-(6-morpholinopyrimidin-4-yl)-4-(1H-1,2,3-triazol-1-yl)-1H-pyrazol-3(2H)-one;1,2-dihydro-2-[6-(4-morpholinyl)-4-pyrimidinyl]-4-(1H-1,2,3-triazol-1-yl)-3H-pyrazol-3-one;2-[6-(4-Morpholinyl)-4-pyrimidinyl]-4-(1H-1,2,3-triazol-1-yl)-1,2-dihydro-3H-pyrazol-3-one
CBNumber: CB72729607
Molecular Formula: C13H14N8O2
Formula Weight: 314.3
MOL File: 1154028-82-6.mol

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Molidustat(BAY 85-3934) Property

Boiling point:: 589.2±60.0 °C(Predicted)
Density: 1.67±0.1 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: insoluble in EtOH; insoluble in H2O; ≥5.68 mg/mL in DMF
form: solid
pka: 5.38±0.37(Predicted)
color: White to off-white

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H302Harmful if swallowed

H360May damage fertility or the unborn child

H372Causes damage to organs through prolonged or repeated exposure

Precautionary statements

P260Do not breathe dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P314Get medical advice/attention if you feel unwell.

P330Rinse mouth.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 15297
Product name: BAY 85-3934
Purity: ≥95%
Packaging: 1mg
Price: $33
Updated: 2024/03/01

Cayman Chemical

Product number: 15297
Product name: BAY 85-3934
Purity: ≥95%
Packaging: 5mg
Price: $137
Updated: 2024/03/01

Cayman Chemical

Product number: 15297
Product name: BAY 85-3934
Purity: ≥95%
Packaging: 10mg
Price: $223
Updated: 2024/03/01

Cayman Chemical

Product number: 15297
Product name: BAY 85-3934
Purity: ≥95%
Packaging: 25mg
Price: $396
Updated: 2024/03/01

ApexBio Technology

Product number: B5861
Product name: Molidustat(BAY85-3934)
Packaging: 10mM(in 1mL DMF)
Price: $100
Updated: 2021/12/16

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Molidustat(BAY 85-3934) Chemical Properties,Usage,Production

Description

Hypoxia-inducible factor (HIF) is the major transcription factor involved in erythropoietin gene expression. Because oxygen-dependent degradation of the α subunit of HIF suppresses erythropoietin expression, stimulation of erythropoiesis by agents that prevent degradation of HIF has been one strategy for managing anemia. BAY 85-3934 stabilizes HIF from degradation in the proteasome by inhibiting HIF-1α prolyl hydroxylase (IC₅₀ = 0.49 μM). Inhibition of HIF prolyl hydroxylase by BAY 85-3934 has been shown to increase endogenous production of erythropoietin. This compound has been investigated in clinical trial for treatment of patients with anemia associated with chronic kidney disease and/or end-stage renal disease.

in vitro

the ic50 values were found to be dependent on the 2-oxoglutarate concentration in the reaction buffer. by lowering the 2-oxoglutarate concentration from 20 μm to 0.3 μm, the potency of the test compound increased up to 10-fold. variation of the concentrations of fe2+ and ascorbate in the reaction buffer by factors of 30 and 200, respectively, did not alter the potency of the inhibitor by more than 2-fold [1].

in vivo

in repeat dosing of bay 85-3934, hemoglobin levels were increased compared with animals in vehicle group, while endogenous epo remained within the normal physiological range. bay 85-3934 therapy was also effective in the treatment of renal anemia in rats with impaired kidney function and, unlike treatment with rhepo, resulted in normalization of hypertensive blood pressure in a rat model of ckd [1].

IC 50

480 nm, 280 nm, and 450 nm for phd1, phd2, and phd3, respectively.

References

[1] flamme i, oehme f, ellinghaus p, jeske m, keldenich j, thuss u. mimicking hypoxia to treat anemia: hif-stabilizer bay 85-3934 (molidustat) stimulates erythropoietin production without hypertensive effects. plos one. 2014 nov 13;9(11):e111838.

Molidustat(BAY 85-3934) Preparation Products And Raw materials

Raw materials

Preparation Products

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Molidustat(BAY 85-3934) Suppliers

China 91 United Kingdom 1 United States 8 Global 100

Chengdu Yuyang High-tech Development Co., Ltd.

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CEG Chemical Science&Technology Co., Ltd.

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View Lastest Price from Molidustat(BAY 85-3934) manufacturers

Wuhan Nutra Biotechnology Co.,Ltd

Product: Molidustat ;BAY85-3934 1154028-82-6
Price: US $0.00-0.00/g
Min. Order: 1g
Purity: 98%
Supply Ability: 100kgs
Release date: 2021-05-24

Career Henan Chemical Co

Product: Molidustat 1154028-82-6
Price: US $1.00/KG
Min. Order: 1KG
Purity: Min98% HPLC
Supply Ability: g/kg/ton
Release date: 2019-12-23

1154028-82-6, Molidustat(BAY 85-3934)Related Search:

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Molidustat(BAY 85-3934)

BAY 85-3934

MOLIDUSTAT

2-[6-(4-Morpholinyl)-4-pyrimidinyl]-4-(1H-1,2,3-triazol-1-yl)-1,2-dihydro-3H-pyrazol-3-one

2-[6-(Morpholin-4-yl)pyrimidin-4-yl]-4-(1H-1,2,3-triazol-1-yl)-1,2-dihydro-3H-pyrazol-3-one

Somatoprim

2-(6-morpholinopyrimidin-4-yl)-4-(1H-1,2,3-triazol-1-yl)-1H-pyrazol-3(2H)-one

1,2-dihydro-2-[6-(4-morpholinyl)-4-pyrimidinyl]-4-(1H-1,2,3-triazol-1-yl)-3H-pyrazol-3-one

BAY 85-3934;BAY-85-3934

2-(6-morpholin-4-ylpyrimidin-4-yl)-4-(triazol-1-yl)-1H-pyrazol-3-one

CS-1728

3H-Pyrazol-3-one, 1,2-dihydro-2-[6-(4-morpholinyl)-4-pyrimidinyl]-4-(1H-1,2,3-triazol-1-yl)-

1154028-82-6

1154025-82-6

C13H14N8O2

Inhibitors

API