4-chloro- Benzo[b]thiophene
- Product Name
- 4-chloro- Benzo[b]thiophene
- CAS No.
- 66490-33-3
- Chemical Name
- 4-chloro- Benzo[b]thiophene
- Synonyms
- 4-Chlorobenzothiophene;4-chloro-1-benzothiophene;4-chloro- Benzo[b]thiophene;Benzo[b]thiophene, 4-chloro-;4-chloro- Benzo[b]thiophene ISO 9001：2015 REACH
- CBNumber
- CB72730773
- Molecular Formula
- C8H5ClS
- Formula Weight
- 168.64
- MOL File
- 66490-33-3.mol
4-chloro- Benzo[b]thiophene Property
- Melting point:
- 81-82 °C
- Boiling point:
- 0.8 °C(Press: 155-165 Torr)
- Density
- 1.349±0.06 g/cm3(Predicted)
- storage temp.
- Keep in dark place,Sealed in dry,Room Temperature
- solubility
- Acetone (Slightly), Chloroform (Slightly)
- form
- Clear Light Yellow Oil to White to Light Yellow Semi-Solid
- Appearance
- Colorless to light yellow Liquid
- InChI
- InChI=1S/C8H5ClS/c9-7-2-1-3-8-6(7)4-5-10-8/h1-5H
- InChIKey
- YGYUMNQONHLLNC-UHFFFAOYSA-N
- SMILES
- C12=CC=CC(Cl)=C1C=CS2
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
- Precautionary statements
-
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- C364180
- Product name
- 4-Chlorobenzothiophene
- Packaging
- 500mg
- Price
- $50
- Updated
- 2021/12/16
- Product number
- C364180
- Product name
- 4-Chlorobenzothiophene
- Packaging
- 1g
- Price
- $80
- Updated
- 2021/12/16
- Product number
- 6517CT
- Product name
- 4-Chlorobenzo[b]thiophene
- Packaging
- 5g
- Price
- $146
- Updated
- 2021/12/16
- Product number
- FC146216
- Product name
- 4-Chlorobenzothiophene
- Packaging
- 1g
- Price
- $54.6
- Updated
- 2021/12/16
- Product number
- FC146216
- Product name
- 4-Chlorobenzothiophene
- Packaging
- 5G
- Price
- $175
- Updated
- 2021/12/16
4-chloro- Benzo[b]thiophene Chemical Properties,Usage,Production
Uses
4-Chlorobenzothiophene is an intermediate used to prepare 1-aryloxy-3-piperidinylpropan-2-ols with dual 5-HT1A receptor antagonism.
Synthesis
23967-57-9
66490-33-3
General procedure for the synthesis of 4-chlorobenzo[b]thiophene from 4-chlorobenzo[b]thiophene-2-carboxylic acid: a mixture of 2-carboxy-4-chlorobenzo[b]thiophene (50.00 g), 1,3-dimethyl-2-imidazolidinone (DMI; 200 ml) and 1,8-diazabicyclo[5.4.0]undec-7-ene (140.7 ml) was prepared by heating and stirring a mixture of 1,8-diazabicyclo[5.4.0]undec-7-ene (140.7 ml) at 160- 195 °C for 6 hours with heating and stirring. After completion of the reaction, the mixture was cooled to 10°C and then slowly added to 3N hydrochloric acid (350 ml) pre-cooled to 10°C. The reaction mixture was extracted with toluene (500 ml) followed by washing the toluene layer sequentially with 3N hydrochloric acid, water, aqueous sodium bicarbonate solution, water, brine and water. After completion of washing, the toluene layer was concentrated to give 4-chlorobenzo[b]thiophene. Yield: 36.78 g. NMR hydrogen spectrum (DMSO-d6) data were as follows: δ 7.38 (1H, t, J = 8.4 Hz), 7.51 (1H, dd, J = 5.5,0.8 Hz), 7.48 (1H, dd, J = 7.7,0.9 Hz), 7.94 (1H, dd, J = 5.5,0.4 Hz), 8.02 (1H. dt, J = 8.0,0.9Hz).
References
[1] Tetrahedron Letters, 2004, vol. 45, # 52, p. 9645 - 9647
[2] Patent: WO2013/15456, 2013, A1. Location in patent: Page/Page column 41; 42
4-chloro- Benzo[b]thiophene Preparation Products And Raw materials
Raw materials
Preparation Products
4-chloro- Benzo[b]thiophene Suppliers
- Tel
- --
- Fax
- --
- sales@carbosynth.com
- Country
- United Kingdom
- ProdList
- 6005
- Advantage
- 58
View Lastest Price from 4-chloro- Benzo[b]thiophene manufacturers
- Product
- 4-Chloro-1-benzothiophene 66490-33-3
- Price
- US $8.80-2.20/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 100kg
- Release date
- 2025-06-27
- Product
- 4-chloro- Benzo[b]thiophene 66490-33-3
- Price
- US $0.00-0.00/kg
- Min. Order
- 1kg
- Purity
- 98%
- Supply Ability
- 1Ton
- Release date
- 2022-09-27
- Product
- 4-chloro- Benzo[b]thiophene 66490-33-3
- Price
- US $2.00/KG
- Min. Order
- 1KG
- Purity
- 98%
- Supply Ability
- 200KG
- Release date
- 2018-08-15