ChemicalBook > CAS DataBase List > GS967

GS967

Product Name: GS967
CAS No.: 1262618-39-2
Chemical Name: GS967
Synonyms: GS967;CS-1742;GS458967;GS-458967;GS 458967;GS967, >98%;GS967(GS-458967);GS-458967 (GS-967;GS967, 10 mM in DMSO;GS-967;GS 967;GS-458967; GS 458967; GS458967
CBNumber: CB72735521
Molecular Formula: C14H7F6N3O
Formula Weight: 347.22
MOL File: 1262618-39-2.mol

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GS967 Property

Density: 1.52±0.1 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: insoluble in H2O; ≥13.35 mg/mL in DMSO; ≥25.52 mg/mL in EtOH with ultrasonic
form: solid
pka: -0.41±0.50(Predicted)
color: White to off-white

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P312Call a POISON CENTER or doctor/physician if you feel unwell.

P321Specific treatment (see … on this label).

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

P362Take off contaminated clothing and wash before reuse.

P403+P233Store in a well-ventilated place. Keep container tightly closed.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 18376
Product name: GS967
Purity: ≥98%
Packaging: 100mg
Price: $238
Updated: 2024/03/01

Cayman Chemical

Product number: 18376
Product name: GS967
Purity: ≥98%
Packaging: 10mg
Price: $88
Updated: 2021/12/16

Cayman Chemical

Product number: 18376
Product name: GS967
Purity: ≥98%
Packaging: 5mg
Price: $49
Updated: 2021/12/16

Cayman Chemical

Product number: 18376
Product name: GS967
Purity: ≥98%
Packaging: 25mg
Price: $93
Updated: 2024/03/01

Cayman Chemical

Product number: 18376
Product name: GS967
Purity: ≥98%
Packaging: 50mg
Price: $146
Updated: 2024/03/01

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GS967 Chemical Properties,Usage,Production

Uses

GS967, also known as GS-458967, is a highly selective late sodium channel current blocker. The selective inhibition of late INa with GS967 can exert antiarrhythmic effects by suppressing EAD- and DAD-mediated extrasystolic activity in PFs and PV and SVC sleeve preparations. Selective late INa inhibition with GS967 exerts potent protective effects against ischemia-induced depolarization and repolarization abnormalities in both atria and ventricles.

Biological Activity

gs967 is a potent, selective and novel inhibitor of cardiac late sodium current (late ina) with ic50=0.13 μm in ventricular myocytes and ic50=0.21μm in isolated hearts. [1]when na+ channels in myocytes fail to inactivate after opening, na+ influx continues throughout the ap plateau. the resulting na+ current (ina) is referred to as late ina. its magnitude is increased in many pathologic conditions, such as in the failing and/or ischemic heart, in the heart exposed to oxidative stress, and in hearts of patients with congenital long qt3 syndromes. [1]in rabbit isolated ventricular myocytes, inhibition of peak ina by gs967 is in a concentration- and voltage-dependent manner with minimal use-dependent, it also decreases the na+ and ca2+ overload. in rabbit-isolated heart, gs967 abolishes tdp induced by atx-ii or e-4031. [1]in anesthetized rabbit, gs967 reduces mapd90 but did not alter cardiac conduction time; it also prevents the induction of arrhythmic activity and tdp by clofilium and decreases the incidence of ischemia-induced arrhythmias. [1]

in vivo

GS967 prevents and reverses proarrhythmic effects of the late I_Na enhancer ATX-II and the I_Kr inhibitor E-4031. GS967 significantly attenuates the proarrhythmic effects of methoxamine 1 clofilium and suppressed ischemia-induced arrhythmias^[1]. GS967 causes a reduction of I_NaP in a frequency-dependent manner, consistent with use-dependent block (UDB). GS967 evokes more potent UDB of I_NaP (IC₅₀=0.07 μM) than ranolazine (16 μM) and lidocaine (17 μM). GS967 is found to exert these same effects on a prototypical long QT syndromemutation (delKPQ)^[2]. GS967 prevents ischemia-induced increases in alternans in the left atrium and left ventricle. GS967 reduces ischemia-induced increases in depolarization heterogeneity and repolarizationheterogeneity. GS967 does not alter heart rate, arterial blood pressure, PR and QT intervals, or QRS duration, but it mildly decreased contractility during ischemia, which was consistent with late INa inhibition^[3].

References

1. belardinelli l, liu g, smith-maxwell c et al. a novel, potent, and selective inhibitor ofcardiac late sodium current suppresses experimental arrhythmias. j pharmacol exp ther. 2013 jan;344(1):23-32.

GS967 Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from GS967 manufacturers

Wuhan Nutra Biotechnology Co.,Ltd

Product: GS967 1262618-39-2
Price: US $0.00-0.00/g
Min. Order: 1g
Purity: 98%
Supply Ability: 100kgs
Release date: 2021-05-24

Career Henan Chemical Co

Product: 6-(4-(trifluoroMethoxy)phenyl)-3-(trifluoroMethyl)-[1,2,4]triazolo[4,3-a]pyridine 1262618-39-2
Price: US $1.00/KG
Min. Order: 1KG
Purity: 98%
Supply Ability: 20kg
Release date: 2019-09-05

1262618-39-2, GS967Related Search:

Entospletinib (GS-9973) GS9620 GSK2643943A GSK J1 GSK-114 GSK-626616 3-[[[2-Methoxy-4-(phenylamino)phenyl]amino]sulfonyl]-2-thiophenecarboxylicacidmethylester Selonsertib Presatovir 4-HYDROXY-2-[(1E)-[4-(1-METHYLETHYL)PHENYL]METHYLENE]HYDRAZIDE

GS967

6-(4-(trifluoroMethoxy)phenyl)-3-(trifluoroMethyl)-[1,2,4]triazolo[4,3-a]pyridine

GS 458967

GS458967

GS-458967

GS-967;GS 967;GS-458967; GS 458967; GS458967

GS967(GS-458967)

GS967, >98%

CS-1742

1,2,4-Triazolo[4,3-a]pyridine, 6-[4-(trifluoromethoxy)phenyl]-3-(trifluoromethyl)-

6-(4-(Trifluoromethoxy)phenyl)-3-(trifluoromethyl)-[1,2,4]triazolo[4,3-a]pyridine , GS967

GS967, 10 mM in DMSO

GS-458967 (GS-967

1262618-39-2

1262618-39-3

C14H7F6N3O

Inhibitors