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Pazopanib-d6

Product Name
Pazopanib-d6
CAS No.
1219592-01-4
Chemical Name
Pazopanib-d6
Synonyms
Pazopanib-d6;2H6]-Pazopanib;2-methyl-5-[[4-[methyl-d3-[3-methyl-2-(methyl-d3)-2H-indazol-6-yl]amino]-2-pyrimidinyl]amino]-benzenesulfonamide;2-methyl-5-({4-[(2H?)methyl[2-(2H?)methyl-3-methyl-2H-indazol-6-yl]amino]pyrimidin-2-yl}amino)benzene-1-sulfonamide
CBNumber
CB72741889
Molecular Formula
C21H23N7O2S
Formula Weight
437.52
MOL File
1219592-01-4.mol
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Pazopanib-d6 Property

storage temp. 
Store at -20°C
solubility 
DMF: 16 mg/ml; DMSO: 16 mg/ml
form 
A solid
color 
White to off-white
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Cayman Chemical
Product number
25446
Product name
Pazopanib-d6
Purity
≥99% deuterated forms (d1-d6)
Packaging
500μg
Price
$290
Updated
2024/03/01
Cayman Chemical
Product number
25446
Product name
Pazopanib-d6
Purity
≥99% deuterated forms (d1-d6)
Packaging
1mg
Price
$549
Updated
2024/03/01
AK Scientific
Product number
3396DH
Product name
2-Methyl-5-[[4-[[3-methyl-2-(trideuteriomethyl)indazol-6-yl]-(trideuteriomethyl)amino]pyrimidin-2-yl]amino]benzenesulfonamide
Packaging
1mg
Price
$710
Updated
2021/12/16
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Pazopanib-d6 Chemical Properties,Usage,Production

Description

Pazopanib-d6 is intended for use as an internal standard for the quantification of pazopanib by GC- or LC-MS. Pazopanib is a multi-kinase inhibitor that inhibits the VEGF receptors VEGFR1, VEGFR2, and VEGFR3 (IC50s = 10, 30, and 47 nM, respectively, in a cell-free enzyme assay).1 It also inhibits PDGFRα, PDGFRβ, and c-Kit (IC50s = 71, 84, and 74 nM, respectively, in a cell-free enzyme assay) as well as additional receptor tyrosine kinases. Pazopanib inhibits upregulation of the surface adhesion proteins ICAM-1 and VCAM-1 induced by VEGF in multiple myeloma cells cocultured with human umbilical vein endothelial cells (HUVECs) and decreases multiple myeloma cell adhesion to HUVECs.2 It also inhibits proliferation of multiple myeloma cells cocultured with HUVECs. Pazopanib (30 and 100 mg/kg) reduces tumor growth, induces apoptosis, decreases angiogenesis, and increases survival in a multiple myeloma mouse xenograft model. Formulations containing pazopanib have been used in the treatment of cancer.

References

1. Kumar, R., Knick, V.B., Rudolph, S.K., et al. Pharmacokinetic-pharmacodynamic correlation from mouse to human with pazopanib, a multikinase angiogenesis inhibitor with potent antitumor and antiangiogenic activity Mol. Cancer Ther. 6(7),2012-2021(2007).
2. Podar, K., Tonon, G., Satler, M., et al. The small-molecule VEGF receptor inhibitor pazopanib (GW786034B) targets both tumor and endothelial cells in multiple myeloma Proc. Natl. Acad. Sci. USA 103(5),19478-19483(2006).

Pazopanib-d6 Preparation Products And Raw materials

Raw materials

Preparation Products

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Pazopanib-d6 Suppliers

China 15 India 1 United States 2 Global 18
ChemStrong Scientific Co.,Ltd
Tel
0755-0755-66853366 13670046396
Fax
0755-28363542
Email
sales@chem-strong.com
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China
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18042
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Artis Biotech Co. Ltd.
Tel
0575-18780151478 18582380095
Fax
0575-89298961
Email
sales@artisbio.com
Country
China
ProdList
2964
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Shanghai Hongye Biotechnology Co. Ltd
Tel
400-9205774
Email
sales@glpbio.cn
Country
China
ProdList
6777
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58
ChemeGen(Shanghai) Biotechnology Co.,Ltd.
Tel
18818260767
Fax
QQ 3610331285
Email
sales@chemegen.com
Country
China
ProdList
11217
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58
Guangzhou Juntang Technology Co., Ltd
Tel
020-36607679 13502246435
Email
sales@dmstandards.com
Country
China
ProdList
10945
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58
TargetMol Chemicals Inc.
Tel
4008200310
Email
marketing@tsbiochem.com
Country
China
ProdList
24647
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58
Shanghai YuZn Pharm. Technology Co.,Ltd.
Tel
15921286451; 15921286451
Email
2010681527@qq.com
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China
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5095
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58
LGC Science (Shanghai) Ltd.
Tel
17717235263
Email
cindy.yang@lgcgroup.com
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China
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15583
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Shanghai Yifei Biotechnology Co. , Ltd.
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021-65675885 18964387627
Email
customer_service@efebio.com
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China
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11974
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58
Nanjing Shizhou Biology Technology Co.,Ltd
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17301488900
Fax
025-85560043
Email
judy.xia@synzest.com
Country
China
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12582
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58
Shaanxi Istare Biotechnology Co., Ltd.
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18682931470
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2142355700@qq.com
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China
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4255
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Shanghai Aitixi Biotechnology Co., Ltd
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18721763493 18721763493
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2493172863@qq.com
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China
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1009
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Nantong Hanfang Biotechnology Co. , Ltd.
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18616537568
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hanfangpharma@126.com
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China
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30961
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58
SHANGHAI ZZBIO CO., LTD.
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15102117276 19921389125
Email
tech@zzbioco.com
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China
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12065
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58
Tel
58896805
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7993601name@qq.com
Country
CHINA
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15092
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1219592-01-4, Pazopanib-d6Related Search:

1,3-DiMethyl-6-aMino-1H-indazole 3-AMINO-4-METHYLBENZENESULFONAMIDE N-(2-Chloropyrimidin-4-YL)-2,3-dimethyl-2H-indazol-6-amine Pazopanib Impurity 9 N-(2-chloropyriMidin-4-yl)-N,2,3-triMethyl-2H-indazol-6-aMine 5-Amino-2-methylbenzenesulfonamide 2-Ethyl-5-nitrobenzenamine ,98% 3-Methyl-6-nitroindazole 2,3-dimethyl-2H-indazol-6-amine hydrochloride 4(1H)-Pyrimidinone, 2-chloro- (9CI) 1,3-Dimethyl-6-nitro-1H-indazole 3-Methyl-6-nitro-2H-indazole 2(1H)-Pyrimidinone, 4-chloro- (6CI,9CI) Pazopanib 2,3-DIMETHYL-6-NITRO-2H-INDAZOLE Pazopanib Related Compound 2 2-Methyl-5-nitrobenzenesulfonamide 5-[[4-[(2,3-DiMethyl-2H-indazol-6-yl)aMino]-2-pyriMidinyl]aMino]-2-MethylbenzenesulfonaMide

  • Pazopanib-d6
  • 2-methyl-5-[[4-[methyl-d3-[3-methyl-2-(methyl-d3)-2H-indazol-6-yl]amino]-2-pyrimidinyl]amino]-benzenesulfonamide
  • 2H6]-Pazopanib
  • 2-methyl-5-({4-[(2H?)methyl[2-(2H?)methyl-3-methyl-2H-indazol-6-yl]amino]pyrimidin-2-yl}amino)benzene-1-sulfonamide
  • 1219592-01-4