ChemicalBook > CAS DataBase List > Evolocumab

Evolocumab

Product Name: Evolocumab
CAS No.: 1256937-27-5
Chemical Name: Evolocumab
Synonyms: AMG 145;Evolocumab;Evolocumab(anti-PCSK9);Research Grade Evolocumab;Evolocumab - solution - 5 mg/ml;Research Grade Evolocumab(DHJ24002);AMG-145,Ser/Thr Protease,Repatha,AMG 145,inhibit,atherosclerotic cardiovascular disease,Serine endopeptidases,PCSK9,Evolocumab,AMG145,Threonine proteases,hypercholesterolemia,LDLR,Inhibitor,Serine proteases
CBNumber: CB72744219
Formula Weight: 0
MOL File: Mol file

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Evolocumab Property

storage temp.: Store at 4°C, protect from light
form: Liquid
color: Colorless to light yellow

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Safety

Hazardous Substances Data: 1256937-27-5(Hazardous Substances Data)

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Biosynth Carbosynth

Product number: BE165589
Product name: Evolocumab - solution - 5 mg/ml
Packaging: 1mg
Price: $550
Updated: 2021/12/16

DC Chemicals

Product number: 013344
Product name: Evolocumab
Packaging: 002
Price: $750
Updated: 2021/12/16

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Evolocumab Chemical Properties,Usage,Production

Uses

Evolocumab (AMG 145) is a human monoclonal antibody that inhibits PCSK9. Evolocumab is used in the study of hypercholesterolemia and atherosclerotic cardiovascular disease. Evolocumab binds to circulating PCSK9 protein and inhibits its binding to LDLR. Evolocumab has antioxidant and cytoprotective activities against H2O2-induced oxidative damage to endothelial cells. Evolocumab may also negatively regulate activation of the TLR-4/NF-κB signaling pathway to prevent inflammation[1][2][3].

Clinical Use

IgG2 monoclonal antibody:
Treatment of hypercholesterolaemia, mixed dyslipidaemia and homozygous familial hypercholesterolaemia

Drug interactions

Potentially hazardous interactions with other drugs
Antipsychotics: avoid with clozapine - increased risk
of agranulocytosis. Vaccines: avoid concomitant use with live vaccines.

Metabolism

Evolocumab is composed of amino acids and carbohydrates as native immunoglobulin and is unlikely to be eliminated via hepatic metabolic mechanisms. Its metabolism and elimination are expected to follow the immunoglobulin clearance pathways, resulting in degradation to small peptides and individual amino acids.

References

[1] Fala L, et, al. Repatha (Evolocumab): Second PCSK9 Inhibitor Approved by the FDA for Patients with Familial Hypercholesterolemia. Am Health Drug Benefits. 2016 Mar;9(Spec Feature):136-9. PMID:27668060
[2] Zhou Q, et al. Protective effect of evolocumab on Müller cells in the rat retina under hyperglycaemic and hypoxic conditions. J Diabetes Complications. 2023 Oct;37(10):108593. DOI:10.1016/j.jdiacomp.2023.108593
[3] Safaeian L, et al. Evolocumab, a PCSK9 inhibitor, protects human endothelial cells against H2O2-induced oxidative stress. Arch Physiol Biochem. 2022 Dec;128(6):1681-1686. DOI:10.1080/13813455.2020.1788605

Evolocumab Preparation Products And Raw materials

Raw materials

Preparation Products

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1256937-27-5, EvolocumabRelated Search:

Adalimumab Ustekinumab Nivolumab Bevacizumab Daratumumab OMALIZUMAB Lambrolizumab Dulaglutide Infliximab Rituximab Panitumumab Trastuzumab Atezolizumab Denosumab CETUXIMAB Ramucirumab ipilimumab Eculizumab

Evolocumab

AMG 145

Research Grade Evolocumab(DHJ24002)

AMG-145,Ser/Thr Protease,Repatha,AMG 145,inhibit,atherosclerotic cardiovascular disease,Serine endopeptidases,PCSK9,Evolocumab,AMG145,Threonine proteases,hypercholesterolemia,LDLR,Inhibitor,Serine proteases

Evolocumab(anti-PCSK9)

Research Grade Evolocumab

Evolocumab - solution - 5 mg/ml

1256937-27-5