ChemicalBook > CAS DataBase List > Evolocumab
Evolocumab
- Product Name
- Evolocumab
- CAS No.
- 1256937-27-5
- Chemical Name
- Evolocumab
- Synonyms
- AMG 145;Evolocumab;Evolocumab(anti-PCSK9);Research Grade Evolocumab(DHJ24002);AMG-145,Ser/Thr Protease,Repatha,AMG 145,inhibit,atherosclerotic cardiovascular disease,Serine endopeptidases,PCSK9,Evolocumab,AMG145,Threonine proteases,hypercholesterolemia,LDLR,Inhibitor,Serine proteases
- CBNumber
- CB72744219
- Formula Weight
- 0
- MOL File
- Mol file
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Evolocumab Property
- storage temp.
- Store at 4°C, protect from light
- form
- Liquid
- color
- Colorless to light yellow
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Safety
- Hazardous Substances Data
- 1256937-27-5(Hazardous Substances Data)
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N-Bromosuccinimide Price
Biosynth Carbosynth
- Product number
- BE165589
- Product name
- Evolocumab - solution - 5 mg/ml
- Packaging
- 1mg
- Price
- $550
- Updated
- 2021/12/16
DC Chemicals
- Product number
- 013344
- Product name
- Evolocumab
- Packaging
- 002
- Price
- $750
- Updated
- 2021/12/16
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Evolocumab Chemical Properties,Usage,Production
Clinical Use
IgG2 monoclonal antibody:Treatment of hypercholesterolaemia, mixed dyslipidaemia and homozygous familial hypercholesterolaemia
Drug interactions
Potentially hazardous interactions with other drugs Antipsychotics: avoid with clozapine - increased risk of agranulocytosis. Vaccines: avoid concomitant use with live vaccines.
Metabolism
Evolocumab is composed of amino acids and carbohydrates as native immunoglobulin and is unlikely to be eliminated via hepatic metabolic mechanisms. Its metabolism and elimination are expected to follow the immunoglobulin clearance pathways, resulting in degradation to small peptides and individual amino acids.
Evolocumab Preparation Products And Raw materials
Raw materials
Preparation Products
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