2-[(4-Bromophenyl)methylene]-N-(2,6-dimethylphenyl)-hydrazinecarboxamide

Product Name: 2-[(4-Bromophenyl)methylene]-N-(2,6-dimethylphenyl)-hydrazinecarboxamide
CAS No.: 415687-81-9
Chemical Name: 2-[(4-Bromophenyl)methylene]-N-(2,6-dimethylphenyl)-hydrazinecarboxamide
Synonyms: EGA;EGA >=98% (HPLC);2-[(4-Bromophenyl)methylene]-N-(2,6-dimethylphenyl)-hydrazinecarboxamide;Hydrazinecarboxamide, 2-[(4-bromophenyl)methylene]-N-(2,6-dimethylphenyl)-
CBNumber: CB72750522
Molecular Formula: C16H16BrN3O
Formula Weight: 346.22
MOL File: 415687-81-9.mol

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2-[(4-Bromophenyl)methylene]-N-(2,6-dimethylphenyl)-hydrazinecarboxamide Property

Density: 1.35±0.1 g/cm3(Predicted)
storage temp.: 2-8°C
solubility: DMSO: soluble5mg/vial, clear (warmed)
form: powder
pka: 11.10±0.46(Predicted)
color: white to beige
Stability:: Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.

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Safety

Hazard Codes: Xi,N
Risk Statements: 36/37/38-50/53
Safety Statements: 26-36/37/39-60-61
WGK Germany: 3

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

H410Very toxic to aquatic life with long lasting effects

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P273Avoid release to the environment.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P321Specific treatment (see … on this label).

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P362Take off contaminated clothing and wash before reuse.

P391Collect spillage. Hazardous to the aquatic environment

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: SML1006
Product name: EGA
Purity: ≥98% (HPLC)
Packaging: 5mg
Price: $120
Updated: 2024/03/01

Sigma-Aldrich

Product number: SML1006
Product name: EGA
Purity: ≥98% (HPLC)
Packaging: 25mg
Price: $476
Updated: 2024/03/01

Cayman Chemical

Product number: 21882
Product name: EGA
Packaging: 1mg
Price: $32
Updated: 2024/03/01

Cayman Chemical

Product number: 21882
Product name: EGA
Packaging: 5mg
Price: $109
Updated: 2024/03/01

Cayman Chemical

Product number: 21882
Product name: EGA
Packaging: 10mg
Price: $153
Updated: 2024/03/01

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2-[(4-Bromophenyl)methylene]-N-(2,6-dimethylphenyl)-hydrazinecarboxamide Chemical Properties,Usage,Production

Description

EGA (415687-81-9) is a novel selective inhibitor of endosomal trafficking which blocks cellular entry of lethal toxin and other acid-dependent bacterial toxins and viruses into mammalian cells.1?Inhibits Anthrax lethal toxin-induced RAW264.7 cell death, IC50=1.7 mM.1 Delays lysosomal targeting and degradation of the EGF receptor indicating that it targets host membrane trafficking.1 Does not block endosomal recycling of transferrin, retrograde trafficking of ricin, phagolysosomal trafficking or phagosome permeabilization by Franciscella tularensis, nor does it neutralize acidic organelles.1 Protects mammalian cells from Clostridium difficile CDT, Clostridium perfringens Iota toxin and Clostridium botulinum C2 toxin.2 A useful tool for exploring subcellular trafficking of various bacterial toxins.3

Uses

EGA is a selective inhibitor of endosomol trafficking pathways exploited by multiple toxins and viruses.

References

Gillespie et al. (2013), Selective inhibitor of endosomal trafficking pathways exploited by multiple toxins and viruses; Proc. Natl. Acad. Sci. USA, 110 E4904 Schnell et al. (2016), EGA Protects Mammalian Cells from Clostridium difficile CDT, Clostridium perfringens Iota Toxin and Clostridium botulinum C2 Toxin; Toxins (Basel), 8 101 Dixon et al. (2015), Distinct Roles for CdtA and CdtC during Intoxication by Cytolethal Distending Toxins; PLoS One, 10 e0143977

2-[(4-Bromophenyl)methylene]-N-(2,6-dimethylphenyl)-hydrazinecarboxamide Preparation Products And Raw materials

Raw materials

Preparation Products

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2-[(4-Bromophenyl)methylene]-N-(2,6-dimethylphenyl)-hydrazinecarboxamide Suppliers

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415687-81-9, 2-[(4-Bromophenyl)methylene]-N-(2,6-dimethylphenyl)-hydrazinecarboxamideRelated Search:

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EGA

2-[(4-Bromophenyl)methylene]-N-(2,6-dimethylphenyl)-hydrazinecarboxamide

EGA >=98% (HPLC)

Hydrazinecarboxamide, 2-[(4-bromophenyl)methylene]-N-(2,6-dimethylphenyl)-

415687-81-9