Methyl trichloroacetate Property

Melting point:

-18°C

Boiling point:

152-153 °C (lit.)

Density 

1.488 g/mL at 25 °C (lit.)

refractive index 

n20/D 1.455(lit.)

Flash point:

163 °F

storage temp. 

room temp

solubility 

1050mg/l

form 

clear liquid

color 

Colorless to Almost colorless

Water Solubility 

Insoluble in water

BRN 

1756075

Dielectric constant

8.7899999999999991

LogP

2.03

CAS DataBase Reference

598-99-2(CAS DataBase Reference)

NIST Chemistry Reference

Acetic acid, trichloro-, methyl ester(598-99-2)

EPA Substance Registry System

Acetic acid, 2,2,2-trichloro-, methyl ester (598-99-2)

Safety

Hazard Codes 

Xi,F

Risk Statements 

36/37/38-40-38-11

Safety Statements 

26-36-16-24-9

RIDADR 

UN 2533 6.1/PG 3

WGK Germany 

3

RTECS 

AJ8380000

TSCA 

Yes

HazardClass 

6.1(b)

PackingGroup 

III

HS Code 

29154000

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H227Combustible liquid

H302Harmful if swallowed

H312Harmful in contact with skin

H315Causes skin irritation

H319Causes serious eye irritation

H331Toxic if inhaled

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

Methyl trichloroacetate Chemical Properties,Usage,Production

Chemical Properties

Colorless clear liquid

Uses

Methyl trichloroacetate was used for negative staining of protein that allowed unmodified proteins to be recovered for biological studies or transblot for amino acid sequence.

Reactions

methyl trichloroacetate reacts with sodium methoxide then the formed product is carbine.

Synthesis Reference(s)

Tetrahedron Letters, 20, p. 3643, 1979 DOI: 10.1016/S0040-4039(01)95485-1

General Description

Methyl trichloroacetate appears as a colorless liquid. Insoluble in water and denser than water. Contact may slightly irritate skin, eyes and mucous membranes. May be toxic by ingestion. Used to make other chemicals.

Air & Water Reactions

Insoluble in water.

Reactivity Profile

A halogenated ester. Esters react with acids to liberate heat along with alcohols and acids. Strong oxidizing acids may cause a vigorous reaction that is sufficiently exothermic to ignite the reaction products. Heat is also generated by the interaction of esters with caustic solutions. Flammable hydrogen is generated by mixing esters with alkali metals and hydrides. A mixture of the ester and trimethylamine reacted violently. Polymerization of a reactive dehydrochlorination of the ester was viewed as the most likely product, along with generous amounts of heat.

Health Hazard

TOXIC; inhalation, ingestion or contact (skin, eyes) with vapors, dusts or substance may cause severe injury, burns or death. Contact with molten substance may cause severe burns to skin and eyes. Reaction with water or moist air will release toxic, corrosive or flammable gases. Reaction with water may generate much heat that will increase the concentration of fumes in the air. Fire will produce irritating, corrosive and/or toxic gases. Runoff from fire control or dilution water may be corrosive and/or toxic and cause pollution.

Fire Hazard

Combustible material: may burn but does not ignite readily. Substance will react with water (some violently) releasing flammable, toxic or corrosive gases and runoff. When heated, vapors may form explosive mixtures with air: indoors, outdoors and sewers explosion hazards. Most vapors are heavier than air. They will spread along ground and collect in low or confined areas (sewers, basements, tanks). Vapors may travel to source of ignition and flash back. Contact with metals may evolve flammable hydrogen gas. Containers may explode when heated or if contaminated with water.