5-HYDROXY-2-METHOXYPYRIDINE

Product Name: 5-HYDROXY-2-METHOXYPYRIDINE
CAS No.: 51834-97-0
Chemical Name: 5-HYDROXY-2-METHOXYPYRIDINE
Synonyms: Aficamten Impurity 9;6-Methoxy-3-pyridinol;6-methoxypyridin-3-ol;3-Pyridinol, 6-methoxy-;Pyronoprene Impurity 48;5-HYDROXY-2-METHOXYPYRIDIN;6-METHOXY-HYDROXY-PYRIDINE;5-hydroxy-2-methoxypridine;3-Pyridinol,6-methoxy-(9CI);5-HYDROXY-2-METHOXYPYRIDINE
CBNumber: CB7281013
Molecular Formula: C6H7NO2
Formula Weight: 125.13
MOL File: 51834-97-0.mol

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5-HYDROXY-2-METHOXYPYRIDINE Property

Melting point:: 81 °C
Boiling point:: 330.1±22.0 °C(Predicted)
Density: 1.190±0.06 g/cm3(Predicted)
storage temp.: Inert atmosphere,Room Temperature
form: crystalline powder
pka: 9.69±0.10(Predicted)
color: Lemony beige
InChI: InChI=1S/C6H7NO2/c1-9-6-3-2-5(8)4-7-6/h2-4,8H,1H3
InChIKey: LKBKDKVMHWPZDB-UHFFFAOYSA-N
SMILES: C1=NC(OC)=CC=C1O

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Safety

HazardClass: IRRITANT
HS Code: 2933399990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H332Harmful if inhaled

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC

Product number: H805290
Product name: 5-Hydroxy-2-methoxypyridine
Packaging: 500mg
Price: $55
Updated: 2021/12/16

TRC

Product number: H805290
Product name: 5-Hydroxy-2-methoxypyridine
Packaging: 1g
Price: $65
Updated: 2021/12/16

TRC

Product number: H805290
Product name: 5-Hydroxy-2-methoxypyridine
Packaging: 10g
Price: $395
Updated: 2021/12/16

Frontier Specialty Chemicals

Product number: M13568
Product name: 2-Methoxy-5-hydroxypyridine
Purity: 98%
Packaging: 1g
Price: $25
Updated: 2021/12/16

SynQuest Laboratories

Product number: 6660-1-U6
Product name: 5-Hydroxy-2-methoxypyridine
Purity: 98%
Packaging: 1g
Price: $40
Updated: 2021/12/16

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5-HYDROXY-2-METHOXYPYRIDINE Chemical Properties,Usage,Production

Uses

5-Hydroxy-2-methoxypyridine, is a heterocyclic building block used in various chemical synthesis.

Synthesis

13472-85-0

51834-97-0

Step 2. Synthesis of 5-hydroxy-2-methoxypyridine: To a stirred solution of 5-bromo-2-methoxypyridine (8.9 g, 47.9 mmol) in tetrahydrofuran (THF, 175 mL) was added slowly and dropwise to a solution of n-butyllithium (2.5 M hexane solution, 28.7 mL, 71.8 mmol) at -78 °C. The reaction was continued for 45 min with stirring. The reaction mixture was stirred continuously at -78 °C for 45 min. Subsequently, trimethyl borate (7.06 mL, 62.2 mmol) was added via syringe and the mixture continued to be stirred at the same temperature for 2 hours. The reaction mixture was warmed up to 0 °C and treated by adding a mixture of 3N NaOH solution (25 mL, 71.77 mmol) and 30% hydrogen peroxide solution (~50 mL). The reaction mixture gradually turned yellow and slightly turbid and was then warmed to room temperature, held for 30 minutes and then heated to reflux temperature and maintained for 1 hour. After completion of the reaction, the mixture was cooled to room temperature. The aqueous layer was neutralized with 1N HCl solution and subsequently extracted with ether (Et2O, 2 x 100 mL). The organic layers were combined, dried with anhydrous sodium sulfate (Na2SO4) and concentrated under reduced pressure to give a yellow viscous oily product (3.5 g, 60% yield).

References

[1] Medicinal Chemistry Research, 2013, vol. 22, # 4, p. 1825 - 1836
[2] Heterocycles, 2002, vol. 57, # 1, p. 55 - 71
[3] Patent: EP1449834, 2004, A2. Location in patent: Page 27
[4] Patent: EP1042305, 2005, B1. Location in patent: Page/Page column 33
[5] Patent: US2003/207914, 2003, A1. Location in patent: Page/Page column 12

5-HYDROXY-2-METHOXYPYRIDINE Preparation Products And Raw materials

Raw materials

Preparation Products

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5-HYDROXY-2-METHOXYPYRIDINE Suppliers

China 171 Europe 1 India 1 United Kingdom 5 United States 17 Global 195

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View Lastest Price from 5-HYDROXY-2-METHOXYPYRIDINE manufacturers

ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD

Product: 6-Methoxy-3-pyridinol 51834-97-0
Price: US $1.10-9.90/KG
Min. Order: 1KG
Purity: 99%min
Supply Ability: 100KG
Release date: 2025-08-20

Henan Aochuang Chemical Co.,Ltd.

Product: 5-Hydroxy-2-methoxypyridine 51834-97-0
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: 1Ton
Release date: 2022-10-14

Dideu Industries Group Limited

Product: 5-HYDROXY-2-METHOXYPYRIDINE 51834-97-0
Price: US $1.10/g
Min. Order: 1g
Purity: 99.00%
Supply Ability: 100 Tons Min
Release date: 2021-09-24

51834-97-0, 5-HYDROXY-2-METHOXYPYRIDINERelated Search:

2-HYDROXY-3-METHOXYPYRIDINE 3-Hydroxy-4-methoxypyridine 5-Methoxy-2,4-pyrimidinediol 4,6-Dihydroxy-5-methoxypyrimidine 3-CYANO-2-HYDROXY-4-METHOXYPYRIDINE 3-Cyano-6-hydroxy-2-methoxypyridine 6-BENZYLOXY-3-HYDROXYPYRIDINE 5-HYDROXY-2-METHOXYPYRIDINE 3-HYDROXY-5-METHOXYPYRIDINE 2-Methoxypyridine 2,5-Dimethoxy-4-methyl-3-nitropyridine 2,5-DIMETHOXYISONICOTINALDEHYDE 2,5-DIMETHOXYNICOTINALDEHYDE 4,7-DIMETHOXY-1H-PYRROLO[2,3-C]PYRIDINE 3-Pyridinol, 6-methoxy-2,4-dimethyl- (9CI) 4-Hydroxy-7-methoxy-6-azaindole 5-NITRO-2-HYDROXY-4-METHOXYPYRIDINE 3-CYANO-2-HYDROXY-4-METHOXYPYRIDINE

5-HYDROXY-2-METHOXYPYRIDINE

3-Pyridinol,6-methoxy-(9CI)

5-Hydroxy-2-methoxylpyridine

5-hydroxy-2-methoxypridine

6-METHOXY-HYDROXY-PYRIDINE

6-methoxypyridin-3-ol

2-Methoxyl-5-hydroxypyridine,6-Methoxypyridin-3-ol

3-Pyridinol, 6-methoxy-

5-HYDROXY-2-METHOXYPYRIDIN

5-HYDROXY-2-METHOXYPYRIDINE ISO 9001：2015 REACH

6-Methoxy-3-pyridinol

Pyronoprene Impurity 48

Aficamten Impurity 9

51834-97-0

Heterocycle-Pyridine series

alcohol

pharmacetical

PYRIDINE