8-BROMOXANTHINE

Uses

Product Name: 8-BROMOXANTHINE
CAS No.: 10357-68-3
Chemical Name: 8-BROMOXANTHINE
Synonyms: NSC 24131;8-BROMOXANTHINE;Zopiclone Impurity 35;8-Bromopurine-2,6-diol;8-BROMOXANTHINE USP/EP/BP;8-Bromo-1H-purine-2,6(3H,7H);8-BroMo-1H-purine-2,6(3H,7H)-dione;8-bromo-3,7-dihydropurine-2,6-dione;8-Bromo-3,9-dihydro-1H-purin-2,6-dione;8-Bromo-3,9-dihydro-1H-purine-2,6-dione
CBNumber: CB7288441
Molecular Formula: C5H3BrN4O2
Formula Weight: 231.01
MOL File: 10357-68-3.mol

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8-BROMOXANTHINE Property

Melting point:: >297°C (dec.)
Density: 2.118±0.06 g/cm3(Predicted)
storage temp.: under inert gas (nitrogen or Argon) at 2-8°C
solubility: DMSO, Methanol
form: Solid
pka: 6.87±0.70(Predicted)
color: Off-White to Pale Beige
InChI: InChI=1S/C5H3BrN4O2/c6-4-7-1-2(8-4)9-5(12)10-3(1)11/h(H3,7,8,9,10,11,12)
InChIKey: ZFQWSCZYQLPFFZ-UHFFFAOYSA-N
SMILES: N1C2=C(NC(=O)NC2=O)NC=1Br

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H317May cause an allergic skin reaction

H319Causes serious eye irritation

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: S359041
Product name: 8-BROMOTHEOPHYLLINE
Purity: Aldrich<sup>CPR</sup>
Packaging: 1 unit
Price: $185
Updated: 2025/07/31

Sigma-Aldrich

Product number: S359041
Product name: 8-BROMOTHEOPHYLLINE
Purity: Aldrich
Packaging: 1g
Price: $179
Updated: 2024/03/01

AK Scientific

Product number: 0861AA
Product name: 8-Bromo-1H-purine-2,6(3H,7H)-dione
Packaging: 250mg
Price: $173
Updated: 2021/12/16

Medical Isotopes, Inc.

Product number: 34952
Product name: 8-Bromo-1H-purine-2,6(3H,7H)-dione
Purity: 95+%
Packaging: 5G
Price: $900
Updated: 2021/12/16

Medical Isotopes, Inc.

Product number: 33560
Product name: 8-Bromoxanthine
Purity: 97%purewithdatedHPLCUVchromatogram
Packaging: 5mg
Price: $935
Updated: 2021/12/16

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8-BROMOXANTHINE Chemical Properties,Usage,Production

Uses

8-Bromoxanthine is used to study Arsenite-inhibited xanthine oxidase.

Uses

8-Bromoxanthine is used to study Arsenite-?inhibited xanthine oxidase.

Synthesis

69-89-6

10357-68-3

General procedure for the synthesis of 8-bromo-1H-purine-2,6(3H,7H)-dione using 1H-purine-2,6(3H,7H)-dione as a raw material: weigh 15g of 1H-purine-2,6(3H,7H)-dione in a 250mL reaction flask, add 250mL of deionized water, and stir until complete dissolution. 7.6 mL of liquid bromine was added slowly dropwise, and the rate of dropwise acceleration was controlled to avoid violent reaction. The reaction mixture was heated to 100 °C and stirring was maintained until the color of the reaction solution faded completely from the red color of the bromine, indicating that the reaction was complete. The heating was stopped and the reaction mixture was cooled to room temperature. The reaction mixture was washed with a small amount of ice water to remove unreacted bromine. Subsequently, the reaction mixture was diafiltered and the solid product was collected. The filter cake was dried in a vacuum drying oven to give 18.4 g of 8-bromo-1H-purine-2,6(3H,7H)-dione.

References

[1] Justus Liebigs Annalen der Chemie, 1883, vol. 221, p. 344
[2] Patent: CN103172633, 2016, B. Location in patent: Paragraph 0145-0147

8-BROMOXANTHINE Preparation Products And Raw materials

Raw materials

Preparation Products

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8-BROMOXANTHINE Suppliers

China 63 Germany 2 India 1 Russia 1 United States 10 Global 77

NANJING DAOGE BIOPHARMA CO.,LTD.

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Wuxi Zhongkun Biochemical Technology Co., Ltd.

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Shanghai HuanChuan Industry Co.,Ltd.

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Nanjing Chalf-Pharm Technology Co., Ltd.

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Sigma-Aldrich

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10357-68-3, 8-BROMOXANTHINERelated Search:

8-Bromo-3H-pyrido[4,3-d]pyrimidin-4-one 1-Piperazinecarboxylicacid,4-methyl-,ethylester(6CI,9CI) 8-METHYLXANTHINE N-(5-Chloro-2-pyridinyl)-2-pyrazinecarboxaMide (Zopiclone IMpurity) Benzyl (3S,4R)-3-ethyl-4-(3-tosyl-3H-imidazo[1,2-a]pyrrolo[2,3-e]pyrazin-8-yl)pyrrolidine-1-carboxylate N-(5-Chloro-2-pyridinyl)-3-(hydroxyMethyl)-2-pyrazinecarboxaMide 8-PHENYLTHEOPHYLLINE 3-(5-CHLOROPYRID-2-YL)CARBAMOYLPYRAZINE-2-CARBOXYLIC ACID(WXG01564) Substituted pyrazine 2-Acetamido-5-chloropyridine CHEMBRDG-BB 7613529 5-BROMOINDOLINE 6-(5-Chloro-2-pyridyl)-5H-pyrrolo[3,4-b]pyrazine-5,7(6H)-dione 4-Methylpiperazine-1-carbonyl chloride 6-(5-CHLORO-PYRIDIN-2-YL)-7-PHENOXYCARBONYLOXY-6,7-DIHYDRO-PYRROLO3,4-BPYRAZIN-5-ONE Zopiclone iMpurity B 1,3,7-Trimethyl-8-bromoxanthine 8-Bromotheophylline

8-BROMOXANTHINE

8-BROMOXANTHINE, HPLC PURIFIED, 98% PURE WITH HPLC UV CHROMATOGRAM

8-Bromo-1H-purine-2,6(3H,7H)

8-BroMo-1H-purine-2,6(3H,7H)-dione

NSC 24131

8-Bromopurine-2,6-diol

8-Bromo-3,9-dihydro-1H-purine-2,6-dione

1H-Purine-2,6-dione, 8-bromo-3,9-dihydro-

8-BROMOXANTHINE USP/EP/BP

8-bromo-3,7-dihydropurine-2,6-dione

Zopiclone Impurity 35

8-Bromo-3,9-dihydro-1H-purin-2,6-dione

10357-68-3

C5H3BrN4O2