2,4-Dichloro-6,7-dimethoxyquinazoline

Product Name: 2,4-Dichloro-6,7-dimethoxyquinazoline
CAS No.: 27631-29-4
Chemical Name: 2,4-Dichloro-6,7-dimethoxyquinazoline
Synonyms: TIMTEC-BB SBB000972;Doxazosin Impurity 6;Doxazosin iMpurity E;Doxazosin EP IMpurity E;7-diMethoxyquinoazoline;Doxazosin Related CoMpound E;Doxazosin Mesilate Impurity E;2,4-Dichloro-6,7-dimethoxyquin;Doxazosin USP Related Compound E;Doxazosin Mesilate EP Impurity E
CBNumber: CB7289392
Molecular Formula: C10H8Cl2N2O2
Formula Weight: 259.09
MOL File: 27631-29-4.mol

More

Less

2,4-Dichloro-6,7-dimethoxyquinazoline Property

Melting point:: 175-178 °C (lit.)
Boiling point:: 340.5±42.0 °C(Predicted)
Density: 1.5369 (rough estimate)
refractive index: 1.6100 (estimate)
storage temp.: 2-8°C
solubility: Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly)
pka: -0.49±0.30(Predicted)
form: Crystalline Powder
color: Pale yellow to beige
Water Solubility: Insoluble in water.
Sensitive: Moisture Sensitive
BRN: 190331
CAS DataBase Reference: 27631-29-4(CAS DataBase Reference)

More

Less

Safety

Hazard Codes: Xi
Risk Statements: 36/37/38
Safety Statements: 37/39-26-36
WGK Germany: 3
HS Code: 29334900

More

Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

More

Less

N-Bromosuccinimide Price

Sigma-Aldrich

Product number: PHR3309
Product name: Doxazosin Related Compound E
Purity: certified reference material, pharmaceutical secondary standard
Packaging: 50mg
Price: $592
Updated: 2025/07/31

Sigma-Aldrich

Product number: 550868
Product name: 2,4-Dichloro-6,7-dimethoxyquinazoline
Purity: 97%
Packaging: 25g
Price: $108
Updated: 2025/07/31

Sigma-Aldrich

Product number: 1225474
Product name: Doxazosin Related Compound E
Purity: United States Pharmacopeia (USP) Reference Standard
Packaging: 20mg
Price: $1300
Updated: 2025/07/31

TCI Chemical

Product number: D3746
Product name: 2,4-Dichloro-6,7-dimethoxyquinazoline
Purity: >98.0%(HPLC)(N)
Packaging: 5g
Price: $188
Updated: 2025/07/31

TRC

Product number: D434230
Product name: 2,4-Dichloro-6,7-dimethoxyquinazoline
Packaging: 25g
Price: $175
Updated: 2021/12/16

More

Less

2,4-Dichloro-6,7-dimethoxyquinazoline Chemical Properties,Usage,Production

Chemical Properties

pale yellow to beige crystalline powder

Uses

An intermediate in the preparation of potential inhibitors of epidermal growth factor receptor kinases. An intermediate in the preparation of Terazosin (T105000).

Uses

2,4-Dichloro-6,7-dimethoxyquinazoline is used as an intermediate in the preparation of potential inhibitors of epidermal growth factor receptor kinases. It is also used as an intermediate in the preparation of terazosin.

Synthesis

28888-44-0

27631-29-4

The general procedure for the synthesis of 2,4-dichloro-6,7-dimethoxyquinazoline from 6,7-dimethoxy-2,4-quinazolinedione was as follows: in a 100 mL three-necked flask equipped with a reflux condenser, 6,7-dimethoxy-2,4-quinazolinedione (1.00 g) and phosphorus triclosan (15 mL; 24.77 g; 161.53 mmol) were added, the reaction mixture was refluxed at 100 °C in an oil bath with stirring for 24 hours. Upon completion of the reaction, the reaction solution was cooled to room temperature and the reaction was quenched by slowly pouring it into an ice-water mixture under vigorous stirring. The precipitated solid was collected by vacuum filtration and the crude product was purified by silica gel column chromatography using dichloromethane as eluent.

References

[1] Journal of Medicinal Chemistry, 1986, vol. 29, # 5, p. 627 - 629
[2] European Journal of Medicinal Chemistry, 2014, vol. 71, p. 1 - 14
[3] Patent: WO2004/13091, 2004, A2. Location in patent: Page 34-35
[4] The Journal of organic chemistry, 2002, vol. 67, # 23, p. 8284 - 8286
[5] Journal of the Chemical Society, 1948, p. 1759,1765

2,4-Dichloro-6,7-dimethoxyquinazoline Preparation Products And Raw materials

Raw materials

Preparation Products

More

Less

2,4-Dichloro-6,7-dimethoxyquinazoline Suppliers

Americas 1 Belgium 2 Canada 1 China 175 Europe 1 Germany 3 India 34 Japan 3 Slovakia 1 Switzerland 3 The Netherlands 2 Ukraine 1 United Kingdom 11 United States 42 Global 280

GLR Innovations

Tel: +91 9891111994
Email: info@glrgroup.in
Country: India
ProdList: 4535
Advantage: 58

TCI Chemicals (India) Pvt. Ltd.

Tel: --
Fax: --
Email: sales-in@tcichemicals.com
Country: India
ProdList: 6768
Advantage: 58

VMB Chem Bio Sys Pvt Ltd.

Tel: --
Fax: --
Email: vmbchem@gmail.com
Country: India
ProdList: 15
Advantage: 0

Chemicea Pharmaceuticals Pvt Ltd

Tel: --
Fax: --
Email: sales@chemicea.com
Country: India
ProdList: 825
Advantage: 58

Biosyn Research Chemicals

Tel: --
Fax: --
Email: info@biosyn.in
Country: India
ProdList: 1340
Advantage: 58

Alfa Aesar

Tel: --
Fax: --
Email: tech@alfa.com
Country: India
ProdList: 6905
Advantage: 58

aSai Vishwa Speciality Chemicals Pvt. Ltd.

Tel: --
Fax: --
Email: draay@asaivishwa.com
Country: India
ProdList: 27
Advantage: 58

Avigya Biosciences Pvt., Ltd.

Tel: --
Fax: --
Email: info@avigyabio.com
Country: India
ProdList: 115
Advantage: 58

Dr. R.R. Organics

Tel: --
Fax: --
Email: drrrorg20@gmail.com
Country: India
ProdList: 200
Advantage: 58

Aruvi Labs

Tel: --
Fax: --
Email: info@aruvilabs.com
Country: India
ProdList: 68
Advantage: 58

Clearsynth Labs

Tel: --
Fax: --
Email: fo@clearsynth.com
Country: India
ProdList: 3887
Advantage: 58

Synthink Research Chemicals

Tel: --
Fax: --
Country: India
ProdList: 398
Advantage: 58

Opulent Pharma

Tel: --
Fax: --
Country: India
ProdList: 810
Advantage: 58

Ms Life Sciences

Tel: --
Fax: --
Country: India
ProdList: 341
Advantage: 58

Pharma Affiliates

Tel: --
Fax: --
Email: @pharmaffiliates.com
Country: India
ProdList: 6754
Advantage: 58

Integrin Life Sciences. Pvt. Ltd.

Tel: --
Fax: --
Email: marketing@integrinlifesciences.com
Country: India
ProdList: 29
Advantage: 58

SynZeal Research Pvt Ltd

Tel: --
Fax: --
Email: standards@synzeal.com
Country: India
ProdList: 6514
Advantage: 58

Pharmaffiliates Analytics and Synthetics P. Ltd

Tel: --
Fax: --
Email: mktg@pharmaffiliates.com
Country: India
ProdList: 6739
Advantage: 58

A.J Chemicals

Tel: --
Fax: --
Email: sales@ajchem.in
Country: India
ProdList: 6100
Advantage: 58

CHEMSWORTH

Tel: --
Fax: --
Email: info@chemsworth.com
Country: India
ProdList: 6700
Advantage: 30

OCEAN TRADING CORPORATION

Tel: --
Fax: --
Email: otcchem@otcchem.com
Country: India
ProdList: 6202
Advantage: 58

More

Less

View Lastest Price from 2,4-Dichloro-6,7-dimethoxyquinazoline manufacturers

Career Henan Chemical Co

Product: 2,4-Dichloro-6,7-dimethoxyquinazoline 27631-29-4
Price: US $1.00/g
Min. Order: 1g
Purity: 99%
Supply Ability: 10000KGS
Release date: 2019-12-24

27631-29-4, 2,4-Dichloro-6,7-dimethoxyquinazolineRelated Search:

Dimethyl carbonate Quinazoline Metformin Primaquine diphosphate Dimethyldimethoxysilane Sulfaquinoxaline 2-Chloropyrimidine 2-Chloroquinazoline 2-CHLORO-6,7-DIMETHOXYQUINAZOLINE 4-CHLORO-6-HYDROXYQUINAZOLINE 4-CHLORO-QUINAZOLINE 4-Chloro-7-methoxyquinazoline 2,4-Dichloroquinazoline 2,4-Dichloro-7-methoxyquinazoline 2,4-Dichloro-6-methoxyquinazoline 2,4-Dichloropyrimidine 4-Chloro-6,7-dimethoxyquinazoline 4-CHLORO-7-HYDROXYQUINAZOLINE

TIMTEC-BB SBB000972

2,4-DICHLORO-6,7-DIMETHOXYQUINAZOLINE

2,4-Dichloro-6,7-dimethoxyquin

Doxazosin Impurity 5（Doxazosin EP Impurity E）

Doxazosin Impurity 6

2-Chloro-6,7-diMethoxyquinazolin-4-yl Chloride

2,4-Dichloro-6-Methoxy-7-quinazolinyl Methyl ether

Doxazosin Related Compound E (20 mg) (2,4-dichloro-6,7-dimethoxyquinazoline)

Doxazosin EP IMpurity E

Doxazosin Related CoMpound E

2,4-DICHLORO-6,7-DIMETHOXYQUINAZOLINETERAZOSIN

2,4-Dichloro-6,7-dimethoxyquinazoline, 98+%

2,4-Dichloro-6,7-dimethoxyxinazoline

2,4-Dichloro-6-methoxy-7-quinazolinyl methyl ether ,98%

2,4-Dichloro-6,7-dimethoxyquinoazoline

2,4-Dichloro-6,7-dimethoxyquinazoline,97%

7-diMethoxyquinoazoline

2,4-Dichloro-6,7-dimethoxyquinazoline 97%

2,4-Dichloro-6,7-dimethoxyquinazoli

2,4-Dichloro-6,7-dimethoxyquinazoline&gt

2,4-Dichloro-6,7-dimethoxyquinazoline ISO 9001：2015 REACH

Doxazosin EP Impurity E/ Doxazosin Related Compund E

Doxazosin Related Compound E (2,4-dichloro-6,7-dimethoxyquinazoline) (1225474)

Doxazosin USP Related Compound E

2,4-Dichloro-6,7-dimethoxyquinazoline (PRAZOSINE)

Doxazosin Mesilate Impurity E

Doxazosin EP Impurity E (Doxazosin USP Related Compound E)

Doxazosin Mesilate EP Impurity E

Doxazosin iMpurity E

27631-29-4

218301-29-4

C10H8Cl2N2O2

C10H8Cl2N3O2

Building Blocks

Quinazolines

Halogenated Heterocycles

Heterocyclic Building Blocks

Building Blocks

Halogenated Heterocycles

Heterocyclic Building Blocks

Quinazolines

QuinazolinesHeterocyclic Building Blocks

Aromatics

Heterocycles

Intermediates & Fine Chemicals

Pharmaceuticals

Quinoline&Isoquinoline

Quinolines, Quinazolines and derivatives

Heterocycles series