2,4-Dichloro-7-methoxyquinazoline

Product Name: 2,4-Dichloro-7-methoxyquinazoline
CAS No.: 62484-31-5
Chemical Name: 2,4-Dichloro-7-methoxyquinazoline
Synonyms: 2,4-Dichloro-7-methoxyquizoline;2,4-Dichloro-7-methoxy-quinazoline;Quinazoline, 2,4-dichloro-7-methoxy-
CBNumber: CB81457849
Molecular Formula: C9H6Cl2N2O
Formula Weight: 229.06
MOL File: 62484-31-5.mol

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2,4-Dichloro-7-methoxyquinazoline Property

Melting point:: 121-121.5 °C
Boiling point:: 316 °C
Density: 1.450
Flash point:: 145 °C
storage temp.: under inert gas (nitrogen or Argon) at 2-8°C
pka: -0.26±0.30(Predicted)
Appearance: White to off-white Solid
InChI: InChI=1S/C9H6Cl2N2O/c1-14-5-2-3-6-7(4-5)12-9(11)13-8(6)10/h2-4H,1H3
InChIKey: DJLGBZOLTZXCHN-UHFFFAOYSA-N
SMILES: N1=C2C(C=CC(OC)=C2)=C(Cl)N=C1Cl

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Safety

HazardClass: IRRITANT

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H332Harmful if inhaled

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC

Product number: D437300
Product name: 2,4-Dichloro-7-methoxyquinazoline
Packaging: 100mg
Price: $90
Updated: 2021/12/16

AK Scientific

Product number: W7455
Product name: 2,4-Dichloro-7-methoxyquinazoline
Packaging: 250mg
Price: $132
Updated: 2021/12/16

AK Scientific

Product number: W7455
Product name: 2,4-Dichloro-7-methoxyquinazoline
Packaging: 1g
Price: $234
Updated: 2021/12/16

Matrix Scientific

Product number: 057334
Product name: 2,4-Dichloro-7-methoxyquinazoline
Purity: 95%
Packaging: 1g
Price: $279
Updated: 2021/12/16

Matrix Scientific

Product number: 057334
Product name: 2,4-Dichloro-7-methoxyquinazoline
Purity: 95%
Packaging: 5g
Price: $877
Updated: 2021/12/16

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2,4-Dichloro-7-methoxyquinazoline Chemical Properties,Usage,Production

Chemical Properties

White flocculent solids

Uses

2,4-Dichloro-7-methoxyquinazoline is a useful reactant for the preparation of 2, 4-?diaminoquinazoline derivatives which is being study for a potential to be a potent PAK4 inhibitors.

Synthesis

62484-12-2

62484-31-5

General procedure for the synthesis of 2,4-dichloro-7-methoxyquinazoline from 7-methoxy-2,4(1H,3H)-quinazoline dione: 7-methoxyquinazoline-2,4-diol (3 g, 15.6 mmol) was mixed with phosphorochloridic acid chloride (10 ml), and the reaction was stirred under reflux conditions overnight. After completion of the reaction, the mixture was cooled to room temperature, slowly poured into ice water and the pH was adjusted to 7-8 with sodium bicarbonate solution.Subsequently, the aqueous layer was extracted with dichloromethane, the organic layers were combined and dried with anhydrous magnesium sulfate. After the solvent was removed by concentration under reduced pressure, the residue was purified by silica gel column chromatography (eluent ratio: n-hexane/ethyl acetate=10/1) to afford the target product 2,4-dichloro-7-methoxyquinazoline (0.64 g) as a white solid.1H NMR (400 MHz, CDCl3) δ 8.12 (d, 1H), 7.37-7.20 (m, 2H) 3.99 (s, 3H).

References

[1] Bioorganic and Medicinal Chemistry, 2008, vol. 16, # 14, p. 7021 - 7032
[2] Journal of Medicinal Chemistry, 2014, vol. 57, # 1, p. 144 - 158
[3] Journal of Medicinal Chemistry, 2015, vol. 58, # 3, p. 1452 - 1465
[4] Patent: US2016/90374, 2016, A1. Location in patent: Paragraph 0218; 0219

2,4-Dichloro-7-methoxyquinazoline Preparation Products And Raw materials

Raw materials

Preparation Products

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2,4-Dichloro-7-methoxyquinazoline Suppliers

China 107 Germany 2 India 1 United States 13 Global 123

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62484-31-5

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