Iminodibenzyl

Product Name: Iminodibenzyl
CAS No.: 494-19-9
Chemical Name: Iminodibenzyl
Synonyms: 10,11-DIHYDRO-5H-DIBENZO[B,F]AZEPINE;2,2'-IMINODIBENZYL;10,11-DIHYDRO-5H-DIBENZ[B,F]AZEPINE;RP 23669;NSC 72110;Iminobibenzyl;IMINODIBENZYL;IMIDODIBENZYL;lminodibenzyl;Iminodibenzyyl
CBNumber: CB7294729
Molecular Formula: C14H13N
Formula Weight: 195.26
MOL File: 494-19-9.mol

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Iminodibenzyl Property

Melting point:: 105-108 °C (lit.)
Boiling point:: 321.94°C (rough estimate)
Density: 1.0778 (rough estimate)
refractive index: 1.6353 (estimate)
storage temp.: Keep in dark place,Sealed in dry,Room Temperature
solubility: Chloroform (Slightly), Ethyl Acetate (Slightly, Heated), Methanol (Slightly)
form: Crystalline Powder
pka: 0.83±0.20(Predicted)
color: Yellow to beige
BRN: 152732
InChI: InChI=1S/C14H13N/c1-3-7-13-11(5-1)9-10-12-6-2-4-8-14(12)15-13/h1-8,15H,9-10H2
InChIKey: ZSMRRZONCYIFNB-UHFFFAOYSA-N
SMILES: N1C2=CC=CC=C2CCC2=CC=CC=C12
LogP: 4.27
CAS DataBase Reference: 494-19-9(CAS DataBase Reference)
NIST Chemistry Reference: 5H-Dibenz[b,f]azepine, 10,11-dihydro-(494-19-9)
EPA Substance Registry System: 5H-Dibenz[b,f]azepine, 10,11-dihydro- (494-19-9)

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Safety

Hazard Codes: Xi
Risk Statements: 36-36/37/38
Safety Statements: 22-24/25-39-26-36/37/39-27
WGK Germany: 3
RTECS: HN8950000
TSCA: Yes
HazardClass: IRRITANT
HS Code: 29339930

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word: Warning
Hazard statements: H317May cause an allergic skin reaction
Precautionary statements: P280Wear protective gloves/protective clothing/eye protection/face protection.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: I1308
Product name: 10,11-Dihydro-5H-dibenz[b,f]azepine
Purity: 97%
Packaging: 25g
Price: $53.1
Updated: 2025/07/31

Sigma-Aldrich

Product number: 1337004
Product name: Iminodibenzyl
Purity: United States Pharmacopeia (USP) Reference Standard
Packaging: 25mg
Price: $1200
Updated: 2025/07/31

TCI Chemical

Product number: D0269
Product name: 10,11-Dihydro-5H-dibenzo[b,f]azepine
Purity: >97.0%(N)
Packaging: 25g
Price: $28
Updated: 2025/07/31

Sigma-Aldrich

Product number: PHR1795
Product name: Iminodibenzyl
Purity: Pharmaceutical Secondary Standard; Certified Reference Material
Packaging: 100mg
Price: $858.8
Updated: 2025/07/31

Usbiological

Product number: 009721
Product name: 10,11-Dihydro-5H-dibenzo[b,f]azepine
Packaging: 10g
Price: $312
Updated: 2021/12/16

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Iminodibenzyl Chemical Properties,Usage,Production

Description

Iminodibenzyl was not a new drug. It had been discovered in 1898 and used briefly as an intermediate, in the preparation of Sky Blue, a dye stuff. Iminodibenzyl, however, had a tricyclic ring structure, similar in appearance to the phenothiazines. Iminodibenzyl is an important drug intermediate, which can be used for the medicine synthesis as a tristimania and epilepsia.

Chemical Properties

YELLOWISH TO BEIGE CRYSTALLINE POWDER

Uses

10,11-Dihydro-5H-dibenzo[b,f]azepine is a metabolite of the tricyclic antidepressant, Imipramine (I465980). 10,11-Dihydro-5H-dibenzo[b,f]azepine can be used as a chromogenic probe for the quantification of hydrogen peroxide and glucose.

Uses

These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

Preparation

Iminodibenzyl is obtained from o-nitrotoluene by condensation, reduction and cyclization.

General Description

Pharmaceutical secondary standards for application in quality control provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards

Synthesis

13080-75-6

494-19-9

The general procedure for the synthesis of iminodibenzylidene from 1-(10,11-dihydro-5H-dibenzo[b,f]azepin-5-yl)ethanone is as follows: NaOH and triethylboron were stirred and mixed under argon protection at room temperature to form a clear, clarified solution with a concentration of 1 M/L. Subsequently, 10 μmol (2 mol%) of catalyst, 5 mmol of amide substrate, and 15 mmol of triethoxysilane or polymethylhydrosiloxane (PMHS) were sequentially added to the above triethylboron solution. The reaction mixture was added to a 10 mL sealed tube along with 2 mL of methyl tert-butyl ether (MTBE) and placed in an 80 °C oil bath with heating and stirring for 6 hours. Upon completion of the reaction, the reaction system was exposed to air and the amine products were subsequently isolated directly by column chromatography. According to the column chromatographic separation, the yield of iminodibenzyl was when triethoxysilane or polymethylhydrosiloxane (PMHS) was used as the reducing agent:

References

[1] Patent: CN107337573, 2017, A. Location in patent: Paragraph 0022; 0023; 0024; 0025

Iminodibenzyl Preparation Products And Raw materials

Raw materials

2-Nitrotoluene

Preparation Products

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View Lastest Price from Iminodibenzyl manufacturers

HANGZHOU HAILAN CHEMICAL CO.,LTD.

Product: Iminodibenzyl 494-19-9
Price: US $0.00/kg
Min. Order: 1kg
Purity: 99%min
Supply Ability: 20tons
Release date: 2025-09-02

Hebei Chuanghai Biotechnology Co., Ltd

Product: Iminodibenzyl 494-19-9
Price: US $10.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 100 mt
Release date: 2024-11-13

Hebei Zhuanglai Chemical Trading Co Ltd

Product: Iminodibenzyl 494-19-9
Price: US $10.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 20 ton
Release date: 2024-11-25

494-19-9, IminodibenzylRelated Search:

Diphenylphosphoryl azide 5-Methyl-1H-benzotriazole Iminodiacetonitrile O-Phthalimide Imipenem Chlorambucil PHTHALIC ACID DISODIUM SALT 4,4'-Methylenedianiline Iminodiacetic acid polyethyleneimine 1H-Benzotriazole Succinimide Potassium hydrogen phthalate Tolyltriazole Dihydromyrcenol Imipenem-Cilastatin sodium hydrate Bismaleimide N,N-Dimethyl-1,4-phenylenediamine

TIMTEC-BB SBB003595

10,11-Dihydro-5-dibenz(b,f)azepine

10,11-Dihydrodibenz[b,f]azepine

2,2’-iminobibenzyl

2,2'-Iminobibenzyl

3,4-Dihydro-2.36.7-dibenzazepine

5H-Dibenzo[b,f]azepine, 10,11-dihydro-

f)azepine,10,11-dihydro-5h-dibenz(

f]azepine,10,11-dihydro-5h-dibenz[

Iminobibenzyl

Iminodibenzyyl

RP 23669

IMINODIBENZYL

IMIDODIBENZYL

2,2'-IMINODIBENZYL

10,11-DIHYDRO-5H-DIBENZ[B,F]AZEPINE

10,11-DIHYDRO-5H-DIBENZO[B,F]AZEPINE

Iminodibenzyl,97%

5H-Dibenzb,fazepine, 10,11-dihydro-

10,11-DIHYDRO-5H-DIBENZ(B,F)AZEPINE(IMINODIBENZYL)

10 11-DIHYDRO-5H-DIBENZ(B F)AZEPINE 98%

IMINODIBENZYLCARBAMAZEPINE

Iminodibenzyl (25 mg)

IMinodibenzyl, 97% 25GR

Iminodibenzyl in stock Factory

Clomipramine Impurity 5（Clomipramine EP Impurity E）

Imipramine Hydrochloride ImpurityⅠ:(Iminodibenzyl)10,11-Dihydro-5H-dibenzo[b,f]azepine

Carbamazepine Impurity 5(Carbamazepine EP Impurity E）

Clomipramine HCl EP Impurity E

NSC 72110

CarbaMazepine EP IMpurity-E

CarbaMazepine iMpurity E

10,11-Dihydro-5H-dibenz[b,f]azepine, 97+%

2,2'-Iminodibenzyl 10,11-Dihydro-5H-dibenzo[b,f]azepine

Oxcarbazepine EP impurity E

Carbamazepine Impurity 5

6,11-dihydro-5H-benzo[b][1]benzazepine

Clomipramine Hydrochloride EP Impurity E

Clomipramine EP Impurity E

10,11-Dihydro-5H-dibenzo[b,f]azepine &gt

10,11-Dihydro-5H-dibenzo[b,f]azepin

Trimipramine maleate EP Impurity F

Clomipramine EP Impurity E (Iminobibenzyl/ Carbamazepine EP Impurity E/ Trimipramine EP Impurity F)

Trimipramine EP Impurity F (Iminobibenzyl/ Carbamazepine EP Impurity E/ Clomipramine EP Impurity E)

Carbamazepine EP Impurity E (Iminobibenzyl/ Trimipramine EP Impurity F/ Clomipramine EP Impurity E)

Iminobibenzyl (Carbamazepine EP Impurity E/ Trimipramine EP Impurity F/ Clomipramine EP Impurity E)

Carbamazepine EP Impurity EQ: What is Carbamazepine EP Impurity E Q: What is the CAS Number of Carbamazepine EP Impurity E Q: What is the storage condition of Carbamazepine EP Impurity E Q: What are the applications of Carbamazepine EP Impurity E

10,11-Dihydro-5H-dibenzo[b,f]-azepine (Iminodibenzyl)

lminodibenzyl

Trimipramine Maleate Impurity F

Carbamazepine EP Impurity E(Clomipramine EP Impurity E)

Clomipramine Hydrochloride Impurity E

Carbamazepine EP Impurity E (Clomipramine HCl EP Impurity E)

10,11-Dihydro-5H-dibenz[b,f]-azepine (Iminodibenzyl) in isooctane

Iminodiphenyl IDB

Carbamazepine EP Impurity E 10,11-dihydro-5H-dibenzo[b,f]azepine (iminodibenzyl)

10,11-Dihydro-5<i>H</i>-dibenz[<i>b,f</i>]azepine

494-19-9