ChemicalBook > CAS DataBase List > DIETHYL (CHLOROMETHYL)PHOSPHONATE

DIETHYL (CHLOROMETHYL)PHOSPHONATE

Product Name: DIETHYL (CHLOROMETHYL)PHOSPHONATE
CAS No.: 3167-63-3
Chemical Name: DIETHYL (CHLOROMETHYL)PHOSPHONATE
Synonyms: NSC 67753;Diethyl (chloromethyl);DIETHYL (CHLOROMETHYL)PHOSPHONATE;[DIETHYL-(CHLORMETHYL)]-PHOSPHONAT;Diethyl chloromethylphosphonate 97%;Diethyl P-(chloromethyl)phosphonate;Diethyl (chloromethyl)phosphonate,98%;Diethyl (Chloromethyl)phosphonate >Diethyl(chloromethyl)phosphonate, 97 %;(chloromethyl)-phosphonicacidiethylester
CBNumber: CB7297881
Molecular Formula: C5H12ClO3P
Formula Weight: 186.57
MOL File: 3167-63-3.mol

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DIETHYL (CHLOROMETHYL)PHOSPHONATE Property

Boiling point:: 109-110 °C10 mm Hg(lit.)
Density: 1.2 g/mL at 25 °C(lit.)
refractive index: n20/D 1.437(lit.)
Flash point:: 188 °F
storage temp.: 2-8°C
solubility: sol THF, ether, dichloromethane, chloroform
form: Liquid
Specific Gravity: 1.2
color: Clear colorless to light yellow
BRN: 1363361
EPA Substance Registry System: Phosphonic acid, (chloromethyl)-, diethyl ester (3167-63-3)

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Safety

Hazard Codes: Xi
Risk Statements: 36/37/38
Safety Statements: 26-36
WGK Germany: 3
Hazard Note: Irritant
HS Code: 29319090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 263613
Product name: Diethyl chloromethylphosphonate
Purity: 97%
Packaging: 1ml
Price: $124
Updated: 2023/06/20

TCI Chemical

Product number: D4588
Product name: Diethyl (Chloromethyl)phosphonate
Purity: >98.0%(GC)
Packaging: 1g
Price: $120
Updated: 2025/07/31

TCI Chemical

Product number: D4588
Product name: Diethyl (Chloromethyl)phosphonate
Purity: >98.0%(GC)
Packaging: 5g
Price: $400
Updated: 2025/07/31

TRC

Product number: D444128
Product name: Diethyl (Chloromethyl)phosphonate
Packaging: 50mg
Price: $45
Updated: 2021/12/16

TRC

Product number: D444128
Product name: Diethyl (Chloromethyl)phosphonate
Packaging: 500mg
Price: $90
Updated: 2021/12/16

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DIETHYL (CHLOROMETHYL)PHOSPHONATE Chemical Properties,Usage,Production

Chemical Properties

Clear colorless to light yellow liquid

Uses

Reactant involved in:

Subsequent alkylation after nucleophilic substitution
One-pot alkylation-boration of α-haloalkylphosphonates
Synthesis of cyclpentane and pyrrolidine derivatives via regioselective insertion reactions
Phosphorylation leading to P-containing cyclopropanes
Wadsworth-Emmons reactions
Ring expansion of zircnacycles via carbenoid insertion

Synthesis Reference(s)

Tetrahedron Letters, 28, p. 3799, 1987 DOI: 10.1016/S0040-4039(00)96387-1

reaction suitability

reaction type: C-C Bond Formation

Synthesis

Diethyl (chloromethyl)phosphonate is synthesized by a preparative scale of (EtO)2P(O)CH2Cl and other (1- chloroalkyl)phosphonates is relatively difficult. Ethanolysis of (chloromethyl)phosphonic dichloride is the most general and useful procedure (eq 1).

References

[1] Patent: WO2016/178162, 2016, A1. Location in patent: Page/Page column 25-26

DIETHYL (CHLOROMETHYL)PHOSPHONATE Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from DIETHYL (CHLOROMETHYL)PHOSPHONATE manufacturers

Shaanxi Dideu Medichem Co. Ltd

Product: DIETHYL (CHLOROMETHYL)PHOSPHONATE 3167-63-3
Price: US $1.00/Kg
Min. Order: 1Kg
Purity: 98%
Supply Ability: 20T
Release date: 2024-07-08

Career Henan Chemical Co

Product: DIETHYL (CHLOROMETHYL)PHOSPHONATE 3167-63-3
Price: US $1.00/g
Min. Order: 1g
Purity: 99.0%
Supply Ability: 100kg
Release date: 2020-01-10

3167-63-3, DIETHYL (CHLOROMETHYL)PHOSPHONATERelated Search:

Dimethyl(pyrrolidin-2-yl)phosphine oxide hydrochloride Dimethyl(piperidin-2-yl)phosphine oxide hydrochloride DIMETHYLPHENYLPHOSPHINE Diethyl (trichloromethyl)phosphonate AURORA KA-221 AURORA KA-1507 DIOCTYL CHLOROMETHYLPHOSPHONATE DIPROPYL CHLOROMETHYLPHOSPHONATE AURORA KA-205 TETRAISOPROPYL DICHLOROMETHYLENE DIPHOSPHONATE AURORA KA-1461 DIBUTYL CHLOROMETHYL PHOSPHONATE Triethyl 2-chloro-2-phosphonoacetate TRIETHYL 2,2-DICHLORO-2-PHOSPHONOACETATE DIETHYL (CHLOROMETHYL)PHOSPHONATE

(chloromethyl)-phosphonicacidiethylester

DIETHYL (CHLOROMETHYL)PHOSPHONATE

[DIETHYL-(CHLORMETHYL)]-PHOSPHONAT

Diethyl(chloromethyl)phosphonate, 97 %

(Chloromethyl)phosphonic acid diethyl ester

Diethyl (chloromethyl)phosphonate,98%

NSC 67753

Diethyl chloromethylphosphonate 97%

Diethyl (chloromethyl)

1-[chloromethyl(ethoxy)phosphoryl]oxyethane

Phosphonic acid P -(chloromethyl)-diethyl ester

Diethyl (Chloromethyl)phosphonate &gt

Diethyl P-(chloromethyl)phosphonate

3167-63-3

C5H12ClO3P

ClCH2POOC2H52

C-C Bond Formation

Olefination

Synthetic Reagents

Horner-Wadsworth-Emmons Reagents

C-C Bond Formation

Horner-Wadsworth-Emmons Reagents

Olefination