(5-METHOXYPYRIDIN-2-YL)METHANOL

Product Name: (5-METHOXYPYRIDIN-2-YL)METHANOL
CAS No.: 127978-70-5
Chemical Name: (5-METHOXYPYRIDIN-2-YL)METHANOL
Synonyms: KML-64;KML-95;5-Methoxy-2-PyridineMethanol;3-Methoxy-6-pyridinemethanol;(5-Methoxy-2-pyridyl)methanol;5-Methoxy pyridine-2-methanol;2-Pyridinemethanol, 5-methoxy-;(5-METHOXYPYRIDIN-2-YL)METHANOL;(5-Methoxypyridine-2-yl)methanol;5-methoxy-2-hydroxymethylpyridine
CBNumber: CB7300273
Molecular Formula: C7H9NO2
Formula Weight: 139.15
MOL File: 127978-70-5.mol

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(5-METHOXYPYRIDIN-2-YL)METHANOL Property

Boiling point:: 262℃
Density: 1.155
Flash point:: 112℃
storage temp.: Inert atmosphere,Room Temperature
pka: 13.22±0.10(Predicted)
Appearance: White to light yellow Solid
InChI: InChI=1S/C7H9NO2/c1-10-7-3-2-6(5-9)8-4-7/h2-4,9H,5H2,1H3
InChIKey: YSGIZFIQWAPBLG-UHFFFAOYSA-N
SMILES: C1(CO)=NC=C(OC)C=C1

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Safety

HS Code: 2933399990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC

Product number: M226555
Product name: (5-Methoxypyridin-2-yl)methanol
Packaging: 500mg
Price: $200
Updated: 2021/12/16

ChemScene

Product number: CS-W006204
Product name: (5-Methoxypyridine-2-yl)methanol
Purity: ≥97.0%
Packaging: 5g
Price: $300
Updated: 2021/12/16

ChemScene

Product number: CS-W006204
Product name: (5-Methoxypyridine-2-yl)methanol
Purity: ≥97.0%
Packaging: 1g
Price: $109
Updated: 2021/12/16

Matrix Scientific

Product number: 119057
Product name: (5-Methoxypyridine-2-yl)methanol
Purity: 95+%
Packaging: 1g
Price: $360
Updated: 2021/12/16

ChemScene

Product number: CS-W006204
Product name: (5-Methoxypyridine-2-yl)methanol
Purity: ≥97.0%
Packaging: 10g
Price: $529
Updated: 2021/12/16

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(5-METHOXYPYRIDIN-2-YL)METHANOL Chemical Properties,Usage,Production

Uses

(5-Methoxypyridin-2-yl)methanol is used in preparation of substituted pyrrolopyridinones as HPK1 antagonists and uses thereof.

Synthesis

75342-32-4

127978-70-5

Compound 12 (CAS: 75342-32-4, 1.40 g, 7.7 mmol) was used as raw material, which was dissolved in methanol (30 mL) and excess potassium hydroxide was added. The reaction mixture was heated to reflux for 2 hours. After completion of the reaction, the solvent was removed by rotary evaporator under reduced pressure. The residue was extracted by partitioning with dichloromethane (20 mL) and water (20 mL). The organic phase was separated, dried with anhydrous sodium sulfate, filtered and concentrated under reduced pressure to give compound 13 (5-methoxypyridine-2-methanol) as a light yellow oil (1.00 g, 93% yield). The product was characterized by 1H NMR (CDCl3): δ 1.82 (s, 1H), 3.87 (s, 3H), 4.70 (s, 2H), 7.18-7.24 (m, 2H), 8.25 (d, 1H, J = 2.8 Hz); GC/MS analysis showed m/z 140 (M++1, 3%), 139 (M+, 44%), 138 ( 100%), 110 (71%).

References

[1] Bioorganic and Medicinal Chemistry, 2015, vol. 23, # 14, p. 3913 - 3924
[2] Patent: US6194437, 2001, B1
[3] Patent: US2006/14945, 2006, A1. Location in patent: Page/Page column 40
[4] Journal of Medicinal Chemistry, 1992, vol. 35, # 3, p. 438 - 450
[5] Patent: WO2007/120729, 2007, A2. Location in patent: Page/Page column 40

(5-METHOXYPYRIDIN-2-YL)METHANOL Preparation Products And Raw materials

Raw materials

Preparation Products

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(5-METHOXYPYRIDIN-2-YL)METHANOL Suppliers

China 101 Europe 1 India 3 Switzerland 1 United Kingdom 1 United States 10 Global 117

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View Lastest Price from (5-METHOXYPYRIDIN-2-YL)METHANOL manufacturers

Career Henan Chemical Co

Product: 5-METHOXYPYRIDIN-2-YL)METHANOL 127978-70-5
Price: US $5.50/KG
Min. Order: 1KG
Purity: 98%min
Supply Ability: 1kg1-100kg
Release date: 2020-01-08

127978-70-5, (5-METHOXYPYRIDIN-2-YL)METHANOLRelated Search:

5-METHOXY-PYRIDIN-3-OL 5-METHOXYPYRIDINE-2-CARBOXYLIC ACID 5-METHOXYPICOLINALDEHYDE 5-Methoxypyridine-3-boronic acid 5-METHOXY-PYRIDINE-3-CARBALDEHYDE 6-Bromo-5-methoxypicolinic acid (6-bromo-5-methoxy-2-pyridinyl)methanol 8-Chloro-3-methoxy-11-(1-methyl-4-piperidinyl)-6,11-dihydro-5H-benzo[5,6]-cyclohepta[1,2-b]pyridin-11-ol 6-CHLORO-5-ETHOXY-2-PYRIDINECARBOXYLIC ACID (5-METHOXYPYRIDIN-2-YL)METHANOL 3-BENZYLHYDROXY-6-HYDROXYMETHYLPYRIDINE-2-CARBOXALDEHYDE HYDROCHLORIDE 3-BENZYLHYDROXY-2,6-DIHYDROXYMETHYLPYRIDINE HYDROCHLORIDE 6-IODO-5-METHOXY-2-PYRIDINECARBOXYLIC ACID 2-HYDROXYMETHYL-3-BENZYLHYDROXYL-6-(2'-NITRO-1'-HYDROXY)ETHYL PYRIDINE 2-Pyridinecarboxylic acid, 5-(2-(trifluoromethyl)phenoxy)-, 2,3-dihydr o-1H-inden-5-yl ester 3-BROMO-5-METHOXYPYRIDINE-2-CARBOXYLIC ACID methyl 6-bromo-5-[(3-methylbenzyl)oxy]-2-pyridinecarboxylate methyl 6-bromo-5-methoxy-2-pyridinecarboxylate

(5-METHOXYPYRIDIN-2-YL)METHANOL

(5-Methoxypyridine-2-yl)methanol

(5-Methoxy-2-pyridyl)methanol

2-(Hydroxymethyl)-5-methoxypyridine

3-Methoxy-6-pyridinemethanol

2-Pyridinemethanol,5-methoxy-(9CI)

5-Methoxy-2-PyridineMethanol

(5-methoxypyridin-2-yl)methanol hydrochloride

5-methoxy-2-hydroxymethylpyridine

2-Pyridinemethanol, 5-methoxy-

5-Methoxy pyridine-2-methanol

KML-64

KML-95

127978-70-5

PYRIDINE