5-METHOXY-PYRIDINE-3-CARBALDEHYDE
Uses- Product Name
- 5-METHOXY-PYRIDINE-3-CARBALDEHYDE
- CAS No.
- 113118-83-5
- Chemical Name
- 5-METHOXY-PYRIDINE-3-CARBALDEHYDE
- Synonyms
- 5-METHOXYNICOTINALDEHYDE;3-FORMYL-5-METHOXYPYRIDINE;3-ForMyl-5-Methoxypyridin...;5-Methoxynicotinaldehyde 97%;5-Methoxypyridin-3-carbaldehyde;5-Methoxy-pyridinecarboxaldehyde;5-Methoxy-3-pyridinecarbaldehyde;5-methxoypyridine-3-carbaldehyde;5-METHOXY-PYRIDINE-3-CARBALDEHYDE;-Methoxy-3-pyridinecarboxaldehyde
- CBNumber
- CB8764353
- Molecular Formula
- C7H7NO2
- Formula Weight
- 137.14
- MOL File
- 113118-83-5.mol
5-METHOXY-PYRIDINE-3-CARBALDEHYDE Property
- Melting point:
- 28-32 °C
- Boiling point:
- 262.1±20.0 °C(Predicted)
- Density
- 1.159±0.06 g/cm3(Predicted)
- Flash point:
- 100 °C
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- form
- solid
- pka
- 2.52±0.10(Predicted)
- Appearance
- Colorless to light yellow <28°C Solid,>32°C Liquid
- InChI
- InChI=1S/C7H7NO2/c1-10-7-2-6(5-9)3-8-4-7/h2-5H,1H3
- InChIKey
- YOVIXSRXKCZJRN-UHFFFAOYSA-N
- SMILES
- C1=NC=C(OC)C=C1C=O
N-Bromosuccinimide Price
- Product number
- M332958
- Product name
- 5-Methoxy-3-pyridinecarboxaldehyde
- Packaging
- 100mg
- Price
- $75
- Updated
- 2021/12/16
- Product number
- X9038
- Product name
- 5-Methoxy-3-pyridinecarboxaldehyde
- Packaging
- 25g
- Price
- $557
- Updated
- 2021/12/16
- Product number
- 4H15-1-X9
- Product name
- 5-Methoxynicotinaldehyde
- Packaging
- 25g
- Price
- $750
- Updated
- 2021/12/16
- Product number
- JK534399
- Product name
- 5-Methoxy-3-pyridinecarboxaldehyde
- Purity
- 98%
- Packaging
- 1g
- Price
- $385
- Updated
- 2021/12/16
- Product number
- F10272
- Product name
- 3-Formyl-5-methoxypyridine
- Purity
- 98%
- Packaging
- 5g
- Price
- $70
- Updated
- 2021/12/16
5-METHOXY-PYRIDINE-3-CARBALDEHYDE Chemical Properties,Usage,Production
Uses
5-Methoxy-pyridine-3-carboxaldehyde is mainly used as an organic synthesis intermediate and can be used to synthesize various organic molecules containing a pyridine skeleton. Its highly reactive aldehyde group makes it an important starting material for synthesizing complex molecules.
Chemical Properties
White to yellow to orange to brown solid
Synthesis
50720-12-2
68-12-2
113118-83-5
3-Bromo-5-methoxypyridine (100 mg, 0.53 mmol) was placed in an oven-dried round-bottomed flask equipped with a magnetic stir bar and dissolved in anhydrous tetrahydrofuran (1 mL). Subsequently, isopropylmagnesium chloride (0.3 mL) was added at 0 °C and the resulting mixture was stirred at room temperature for 2 h (the solution turned light brown). Then, anhydrous tetrahydrofuran (0.1 mL) solution of N,N-dimethylformamide (0.1 mL) was slowly added. The initially formed solid gradually dissolved and the color of the solution changed from light brown to light yellow. after 1 h, the reaction mixture was cooled to 0 °C and the reaction was quenched with deionized water (2 mL). The organic layer was separated and the aqueous layer was further extracted with dichloromethane (3 x 3 mL). The organic layers were combined and dried over anhydrous sodium sulfate and subsequently concentrated in vacuum on a rotary evaporator. The crude product was purified by gradient silica gel column chromatography with the eluent being a solvent mixture of hexane and ethyl acetate (ratio from 20:1 to 1:1) to afford the target product 5-methoxy-pyridine-3-carbaldehyde as a colorless slurry (45 mg, 63% yield).1H NMR (500 MHz, CDCl3): δ 10.09 (s, 1H), 8.65 (d, J = 0.9 Hz, 1H), 8.54 (d, J = 3.1 Hz, 1H), 7.60 (dd, J = 5.1, 1.5 Hz, 1H).13C NMR (125 MHz, CDCl3): δ 190.6, 156.2, 145.1, 144.8, 132.0, 116.3, 55.7.
References
[1] Tetrahedron Letters, 2005, vol. 46, # 11, p. 1867 - 1871
[2] Tetrahedron, 2001, vol. 57, # 20, p. 4447 - 4454
[3] Biochemistry, 2010, vol. 49, # 49, p. 10421 - 10439
[4] Patent: US2014/309427, 2014, A1. Location in patent: Paragraph 0157; 0158
[5] Patent: WO2007/84560, 2007, A2. Location in patent: Page/Page column 164
5-METHOXY-PYRIDINE-3-CARBALDEHYDE Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 5-METHOXY-PYRIDINE-3-CARBALDEHYDE manufacturers
- Product
- 5-METHOXY-PYRIDINE-3-CARBALDEHYDE 113118-83-5
- Price
- US $1.10/g
- Min. Order
- 1g
- Purity
- 99.00%
- Supply Ability
- 100 Tons Min
- Release date
- 2021-10-26
- Product
- 5-METHOXY-PYRIDINE-3-CARBALDEHYDE 113118-83-5
- Price
- US $15.00-10.00/KG
- Min. Order
- 1KG
- Purity
- 99%+ HPLC
- Supply Ability
- Monthly supply of 1 ton
- Release date
- 2021-06-27
- Product
- 5-METHOXY-PYRIDINE-3-CARBALDEHYDE 113118-83-5
- Price
- US $1.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- Customized
- Release date
- 2018-12-14