2-METHOXYPYRIDINE-4-CARBOXALDEHYDE
- Product Name
- 2-METHOXYPYRIDINE-4-CARBOXALDEHYDE
- CAS No.
- 72716-87-1
- Chemical Name
- 2-METHOXYPYRIDINE-4-CARBOXALDEHYDE
- Synonyms
- 2-METHOXYISONICOTINALDEHYDE;2-Methoxy-pyridine-4-carbaldehyde;4-FORMYL-2-METHOXYPYRIDINE;2-Methoxy-4-aldehydepyridine;2-Methoxypyridine-4-carbo...;2-Methoxyisonicotinaldehyde 98%;2-Methoxy-4-pyridinecarbaldehyde;2-Methoxypyridin-4-carboxaldehyde;2-methoxypyridine-4-carboxaldehye;2-METHOXYPYRIDINE-4-CARBOXALDEHYDE
- CBNumber
- CB2138149
- Molecular Formula
- C7H7NO2
- Formula Weight
- 137.14
- MOL File
- 72716-87-1.mol
2-METHOXYPYRIDINE-4-CARBOXALDEHYDE Property
- Melting point:
- 33-36 °C
- Boiling point:
- 234.6±20.0 °C(Predicted)
- Density
- 1.159±0.06 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- form
- solid
- pka
- 1.43±0.10(Predicted)
- color
- White to off-white
- InChI
- InChI=1S/C7H7NO2/c1-10-7-4-6(5-9)2-3-8-7/h2-5H,1H3
- InChIKey
- VOCKNCWQVHJMAE-UHFFFAOYSA-N
- SMILES
- C1(OC)=NC=CC(C=O)=C1
Safety
- HS Code
- 2933399990
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
N-Bromosuccinimide Price
- Product number
- M218830
- Product name
- 2-Methoxyisonicotinaldehyde
- Packaging
- 100mg
- Price
- $75
- Updated
- 2021/12/16
- Product number
- W8122
- Product name
- 2-Methoxypyridine-4-carboxaldehyde
- Packaging
- 5g
- Price
- $251
- Updated
- 2021/12/16
- Product number
- 074383
- Product name
- 2-Methoxypyridine-4-carboxaldehyde
- Purity
- 95+%
- Packaging
- 5g
- Price
- $200
- Updated
- 2021/12/16
- Product number
- M13072
- Product name
- 2-Methoxypyridin-4-carboxaldehyde
- Purity
- 98%
- Packaging
- 1g
- Price
- $35
- Updated
- 2021/12/16
- Product number
- 074383
- Product name
- 2-Methoxypyridine-4-carboxaldehyde
- Purity
- 95+%
- Packaging
- 1g
- Price
- $47
- Updated
- 2021/12/16
2-METHOXYPYRIDINE-4-CARBOXALDEHYDE Chemical Properties,Usage,Production
Synthesis
123148-66-3
72716-87-1
Lithium aluminum hydride (1.9 g, 49 mmol) was added batchwise to a solution of 2-methoxyisonicotinic acid (5.0 g, 33 mmol) in tetrahydrofuran (40 mL) at 0 °C. The reaction mixture was stirred continuously at 0 °C for 1 h, followed by slow dropwise addition of saturated sodium sulfate solution for quenching. The reaction solution was filtered and the filtrate was extracted with ethyl acetate and the organic layer was washed with saturated brine and subsequently concentrated under reduced pressure. The resulting residue was dissolved in dichloromethane (30 mL) and chromium trioxide pyridine complex (10.6 g, 49 mmol) was added. The mixture was stirred at room temperature for 2 h. After completion of the reaction, the mixture was filtered through a short silica gel column and eluted with ethyl acetate. The eluate was concentrated under reduced pressure to remove the solvent. The residue was purified by column chromatography (petroleum ether: ethyl acetate = 10:1) to afford the target product 2-methoxypyridine-4-aldehyde (646 mg, 14% yield). The product was characterized by 1H NMR (CDCl3): δ 10.01 (1H, s), 8.36 (1H, d, J = 5.2 Hz), 7.29 (1H, dd, J = 1.2 Hz, 5.2 Hz), 7.14 (1H, d, J = 1.2 Hz), 3.99 (3H, s).
References
[1] Journal of Organic Chemistry, 1989, vol. 54, # 23, p. 5580 - 5585
[2] Patent: EP2816032, 2014, A1. Location in patent: Paragraph 0458
[3] Patent: EP2862571, 2015, A1. Location in patent: Paragraph 0103; 0104
[4] Patent: US2016/168139, 2016, A1. Location in patent: Paragraph 0942; 0943
2-METHOXYPYRIDINE-4-CARBOXALDEHYDE Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 2-METHOXYPYRIDINE-4-CARBOXALDEHYDE manufacturers
- Product
- 2-METHOXYPYRIDINE-4-CARBOXALDEHYDE 72716-87-1
- Price
- US $1.10/g
- Min. Order
- 1g
- Purity
- 99.00%
- Supply Ability
- 100 Tons Min
- Release date
- 2021-10-26
- Product
- 2-METHOXYPYRIDINE-4-CARBOXALDEHYDE 72716-87-1
- Price
- US $1.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- Customized
- Release date
- 2018-12-14