ChemicalBook > CAS DataBase List > ETC-1002

ETC-1002

Product Name
ETC-1002
CAS No.
738606-46-7
Chemical Name
ETC-1002
Synonyms
Bempedoic Acid;Pentadecanedioic acid, 8-hydroxy-2,2,14,14-tetramethyl-;CS-1544;ETC-1002;ESP 55016;Bempedoic;Bempedoate;Bempdic acid;Bempedoic Acid, API;ETC-1002 (ESP 55016)
CBNumber
CB73034632
Molecular Formula
C19H36O5
Formula Weight
344.49
MOL File
738606-46-7.mol
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ETC-1002 Property

Melting point:
87 - 92°C
Boiling point:
506.5±35.0 °C(Predicted)
Density 
1.045±0.06 g/cm3(Predicted)
storage temp. 
Refrigerator
solubility 
Chloroform (Slightly), Methanol (Slightly)
pka
4.55±0.45(Predicted)
form 
Solid
color 
White to Off-White
InChI
InChI=1S/C19H36O5/c1-18(2,16(21)22)13-9-5-7-11-15(20)12-8-6-10-14-19(3,4)17(23)24/h15,20H,5-14H2,1-4H3,(H,21,22)(H,23,24)
InChIKey
HYHMLYSLQUKXKP-UHFFFAOYSA-N
SMILES
C(O)(=O)C(C)(C)CCCCCC(O)CCCCCC(C)(C)C(O)=O
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Cayman Chemical
Product number
26409
Product name
ETC-1002
Packaging
25mg
Price
$78
Updated
2024/03/01
Cayman Chemical
Product number
26409
Product name
ETC-1002
Packaging
50mg
Price
$122
Updated
2024/03/01
Cayman Chemical
Product number
26409
Product name
ETC-1002
Packaging
5mg
Price
$32
Updated
2024/03/01
Cayman Chemical
Product number
26409
Product name
ETC-1002
Packaging
10mg
Price
$50
Updated
2024/03/01
TRC
Product number
B119700
Product name
BempedoicAcid
Packaging
250mg
Price
$605
Updated
2021/12/16
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ETC-1002 Chemical Properties,Usage,Production

Description

Etc-1002 is a small molecule that can be used orally to lower LDL-C and is an activator of LIVER AMPK. ETC-1002 has an effective inhibitory effect on liver ATP-Citrate lyase.

Description

ETC-1002 is a prodrug form of ETC-1002-CoA. ETC-1002 is conjugated to coenzyme A (CoA) by very long-chain acyl-CoA synthetase-1 (ACSVL1) to form ETC-1002-CoA, which inhibits ATP citrate lyase (Ki = 2 μM) and activates AMP-activated protein kinase (AMPK). ETC-1002 suppresses total lipid synthesis in wild-type and AMPKβ1 knockout primary murine hepatocytes. In vivo, ETC-1002 (30 mg/kg) prevents increases in hepatic cholesterol and reduces the size of aortic atherosclerotic lesions induced by a high-fat high-cholesterol diet in Apoe-/-/Ampkβ1-/- (DKO) mice.

Uses

ETC-1002 (Bempedoic acid, ESP-55016),also known as Bempedoic acid, is an orally available, once-daily LDL-C lowering small molecule designed to lower elevated levels of LDL-C and to avoid side effects associated with existing LDL-C lowering therapies.ETC-1002 is an activator of hepatic AMP-activated protein kinase (AMPK). It has potent inhibitory activity against hepatic ATP-citrate lyase(IC50=29 uM).

Definition

ChEBI: Bempedoic acid is an alpha,omega-dicarboxylic acid that is pentadecanedioic acid which is substituted by methyl groups groups at positions 2 and 14, and by a hydroxy group at position 8. It is a drug used for the treatment of high LDL cholesterol, which is sometimes referred to as 'bad cholesterol'. It has a role as an antilipemic drug, an EC 2.3.3.8 (ATP citrate synthase) inhibitor and a prodrug.

ETC-1002 Preparation Products And Raw materials

Raw materials

Preparation Products

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ETC-1002 Suppliers

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View Lastest Price from ETC-1002 manufacturers

PNP Biotech Co. Ltd
Product
Bempedoic Acid 738606-46-7
Price
US $0.00/KG
Min. Order
25KG
Purity
98%
Supply Ability
Inquiry
Release date
2022-09-29
WUHAN FORTUNA CHEMICAL CO., LTD
Product
Bempedoic acid 738606-46-7
Price
US $0.00/G
Min. Order
1G
Purity
98%min
Supply Ability
30kg/month
Release date
2023-02-02
Henan Aochuang Chemical Co.,Ltd.
Product
Bempedoic acid (ETC-1002) 738606-46-7
Price
US $0.00-0.00/kg
Min. Order
1kg
Purity
98%
Supply Ability
1Ton
Release date
2022-10-10

738606-46-7, ETC-1002Related Search:

Bempedoic Acid Impurity 1-d4 Bempedoic Acid-d4

  • ETC-1002
  • Bempedoic Acid
  • ETC-1002 (ESP 55016)
  • ESP 55016
  • ETC-1002(BEMPEDOIC ACID)
  • CS-1544
  • Bempedoic Acid(ETC-1002
  • Bempedoate
  • ESP-55016; ESP55016; ESP 55016; ETC-1002; ETC 1002; ETC1002; BEMPEDOATE; BEMPEDOIC ACID
  • BEMPEDOIC ACID;ESP-55016;SGI-7079
  • Pentadecanedioic acid, 8-hydroxy-2,2,14,14-tetramethyl-
  • Bempdic acid
  • Bempedoic acid In-House
  • 8-hydroxy-2,2,14,14-tetramethylpentadecanedioicaci
  • Bempedoic Acid, API
  • Bempedoic
  • 738606-46-7
  • API