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Bempedoic acid

Product Name
Bempedoic acid
CAS No.
738606-46-7
Chemical Name
Bempedoic acid
Synonyms
Bempedoic Acid;Pentadecanedioic acid, 8-hydroxy-2,2,14,14-tetramethyl-;CS-1544;ETC-1002;ESP 55016;Bempedoic;Bempedoate;Bempdic acid;Bepidoic acid;Bempedoic Acid, API
CBNumber
CB73034632
Molecular Formula
C19H36O5
Formula Weight
344.49
MOL File
738606-46-7.mol
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Bempedoic acid Property

Melting point:
87 - 92°C
Boiling point:
506.5±35.0 °C(Predicted)
Density 
1.045±0.06 g/cm3(Predicted)
storage temp. 
Refrigerator
solubility 
Chloroform (Slightly), Methanol (Slightly)
pka
4.55±0.45(Predicted)
form 
Solid
color 
White to Off-White
InChI
InChI=1S/C19H36O5/c1-18(2,16(21)22)13-9-5-7-11-15(20)12-8-6-10-14-19(3,4)17(23)24/h15,20H,5-14H2,1-4H3,(H,21,22)(H,23,24)
InChIKey
HYHMLYSLQUKXKP-UHFFFAOYSA-N
SMILES
C(O)(=O)C(C)(C)CCCCCC(O)CCCCCC(C)(C)C(O)=O
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Cayman Chemical
Product number
26409
Product name
ETC-1002
Packaging
25mg
Price
$78
Updated
2024/03/01
Cayman Chemical
Product number
26409
Product name
ETC-1002
Packaging
50mg
Price
$122
Updated
2024/03/01
Cayman Chemical
Product number
26409
Product name
ETC-1002
Packaging
5mg
Price
$32
Updated
2024/03/01
Cayman Chemical
Product number
26409
Product name
ETC-1002
Packaging
10mg
Price
$50
Updated
2024/03/01
TRC
Product number
B119700
Product name
BempedoicAcid
Packaging
250mg
Price
$605
Updated
2021/12/16
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Bempedoic acid Chemical Properties,Usage,Production

Description

Etc-1002 is a small molecule that can be used orally to lower LDL-C and is an activator of LIVER AMPK. ETC-1002 has an effective inhibitory effect on liver ATP-Citrate lyase.

Description

ETC-1002 is a prodrug form of ETC-1002-CoA. ETC-1002 is conjugated to coenzyme A (CoA) by very long-chain acyl-CoA synthetase-1 (ACSVL1) to form ETC-1002-CoA, which inhibits ATP citrate lyase (Ki = 2 μM) and activates AMP-activated protein kinase (AMPK). ETC-1002 suppresses total lipid synthesis in wild-type and AMPKβ1 knockout primary murine hepatocytes. In vivo, ETC-1002 (30 mg/kg) prevents increases in hepatic cholesterol and reduces the size of aortic atherosclerotic lesions induced by a high-fat high-cholesterol diet in Apoe-/-/Ampkβ1-/- (DKO) mice.

Uses

ETC-1002 (Bempedoic acid, ESP-55016),also known as Bempedoic acid, is an orally available, once-daily LDL-C lowering small molecule designed to lower elevated levels of LDL-C and to avoid side effects associated with existing LDL-C lowering therapies.ETC-1002 is an activator of hepatic AMP-activated protein kinase (AMPK). It has potent inhibitory activity against hepatic ATP-citrate lyase(IC50=29 uM).

Definition

ChEBI: Bempedoic acid is an alpha,omega-dicarboxylic acid that is pentadecanedioic acid which is substituted by methyl groups groups at positions 2 and 14, and by a hydroxy group at position 8. It is a drug used for the treatment of high LDL cholesterol, which is sometimes referred to as 'bad cholesterol'. It has a role as an antilipemic drug, an EC 2.3.3.8 (ATP citrate synthase) inhibitor and a prodrug.

Indications

Bempedoic acid (ETC-1002) is a lipid-lowering agent approved by the FDA for use as an adjunct to maximally tolerated statin therapy for the reduction of LDL cholesterol, particularly in patients with atherosclerotic cardiovascular disease (ASCVD) and heterozygous familial hypercholesterolaemia (HeFH).

brand name

NEXLETOL, NEXLIZET

Mechanism of action

Bempedoic acid (ETC-1002) inhibits cholesterol biosynthesis by inhibiting adenosine triphosphate-citrate lyase (ACL), which in turn inhibits cholesterol biosynthesis, leading to an increase in the expression of the LDL receptor and an enhancement of the plasma clearance of low-density lipoproteins (LDL-C). ETC-1002 is an orally active prodrug that is intracellularly activated. ETC-1002 activates AMPK, which in turn inhibits the production of pro-inflammatory cytokines and chemokines, and also contributes to the amelioration of diseases such as ASCVD and HeFH.

Bempedoic acid Preparation Products And Raw materials

Raw materials

Preparation Products

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Bempedoic acid Suppliers

China 229 India 24 United States 12 Global 265
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View Lastest Price from Bempedoic acid manufacturers

WUHAN FORTUNA CHEMICAL CO., LTD
Product
Bempedoic acid 738606-46-7
Price
US $0.00/G
Min. Order
1G
Purity
98%min
Supply Ability
30kg/month
Release date
2023-02-02
Hebei Mojin Biotechnology Co., Ltd
Product
Bempedoic acid 738606-46-7
Price
US $0.00/KG
Min. Order
1KG
Purity
99.1%
Supply Ability
50000KG/month
Release date
2024-10-22
PNP Biotech Co. Ltd
Product
Bempedoic Acid 738606-46-7
Price
US $0.00/KG
Min. Order
25KG
Purity
98%
Supply Ability
Inquiry
Release date
2022-09-29

738606-46-7, Bempedoic acidRelated Search:

Bempedoic Acid Impurity 1-d4 Bempedoic Acid-d4

  • ETC-1002
  • Bempedoic Acid
  • ETC-1002 (ESP 55016)
  • ESP 55016
  • ETC-1002(BEMPEDOIC ACID)
  • CS-1544
  • Bempedoic Acid(ETC-1002
  • Bempedoate
  • ESP-55016; ESP55016; ESP 55016; ETC-1002; ETC 1002; ETC1002; BEMPEDOATE; BEMPEDOIC ACID
  • BEMPEDOIC ACID;ESP-55016;SGI-7079
  • Pentadecanedioic acid, 8-hydroxy-2,2,14,14-tetramethyl-
  • Bempdic acid
  • Bempedoic acid In-House
  • 8-hydroxy-2,2,14,14-tetramethylpentadecanedioicaci
  • Bempedoic Acid, API
  • Bempedoic
  • Bepidoic acid
  • 738606-46-7
  • API