ETC-1002
- Product Name
- ETC-1002
- CAS No.
- 738606-46-7
- Chemical Name
- ETC-1002
- Synonyms
- Bempedoic Acid;Pentadecanedioic acid, 8-hydroxy-2,2,14,14-tetramethyl-;CS-1544;ETC-1002;ESP 55016;Bempedoic;Bempedoate;Bempdic acid;Bempedoic Acid, API;ETC-1002 (ESP 55016)
- CBNumber
- CB73034632
- Molecular Formula
- C19H36O5
- Formula Weight
- 344.49
- MOL File
- 738606-46-7.mol
ETC-1002 Property
- Melting point:
- 87 - 92°C
- Boiling point:
- 506.5±35.0 °C(Predicted)
- Density
- 1.045±0.06 g/cm3(Predicted)
- storage temp.
- Refrigerator
- solubility
- Chloroform (Slightly), Methanol (Slightly)
- pka
- 4.55±0.45(Predicted)
- form
- Solid
- color
- White to Off-White
- InChI
- InChI=1S/C19H36O5/c1-18(2,16(21)22)13-9-5-7-11-15(20)12-8-6-10-14-19(3,4)17(23)24/h15,20H,5-14H2,1-4H3,(H,21,22)(H,23,24)
- InChIKey
- HYHMLYSLQUKXKP-UHFFFAOYSA-N
- SMILES
- C(O)(=O)C(C)(C)CCCCCC(O)CCCCCC(C)(C)C(O)=O
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 26409
- Product name
- ETC-1002
- Packaging
- 25mg
- Price
- $78
- Updated
- 2024/03/01
- Product number
- 26409
- Product name
- ETC-1002
- Packaging
- 50mg
- Price
- $122
- Updated
- 2024/03/01
- Product number
- 26409
- Product name
- ETC-1002
- Packaging
- 5mg
- Price
- $32
- Updated
- 2024/03/01
- Product number
- 26409
- Product name
- ETC-1002
- Packaging
- 10mg
- Price
- $50
- Updated
- 2024/03/01
- Product number
- B119700
- Product name
- BempedoicAcid
- Packaging
- 250mg
- Price
- $605
- Updated
- 2021/12/16
ETC-1002 Chemical Properties,Usage,Production
Description
Etc-1002 is a small molecule that can be used orally to lower LDL-C and is an activator of LIVER AMPK. ETC-1002 has an effective inhibitory effect on liver ATP-Citrate lyase.
Description
ETC-1002 is a prodrug form of ETC-1002-CoA. ETC-1002 is conjugated to coenzyme A (CoA) by very long-chain acyl-CoA synthetase-1 (ACSVL1) to form ETC-1002-CoA, which inhibits ATP citrate lyase (Ki = 2 μM) and activates AMP-activated protein kinase (AMPK). ETC-1002 suppresses total lipid synthesis in wild-type and AMPKβ1 knockout primary murine hepatocytes. In vivo, ETC-1002 (30 mg/kg) prevents increases in hepatic cholesterol and reduces the size of aortic atherosclerotic lesions induced by a high-fat high-cholesterol diet in Apoe-/-/Ampkβ1-/- (DKO) mice.
Uses
ETC-1002 (Bempedoic acid, ESP-55016),also known as Bempedoic acid, is an orally available, once-daily LDL-C lowering small molecule designed to lower elevated levels of LDL-C and to avoid side effects associated with existing LDL-C lowering therapies.ETC-1002 is an activator of hepatic AMP-activated protein kinase (AMPK). It has potent inhibitory activity against hepatic ATP-citrate lyase(IC50=29 uM).
Definition
ChEBI: Bempedoic acid is an alpha,omega-dicarboxylic acid that is pentadecanedioic acid which is substituted by methyl groups groups at positions 2 and 14, and by a hydroxy group at position 8. It is a drug used for the treatment of high LDL cholesterol, which is sometimes referred to as 'bad cholesterol'. It has a role as an antilipemic drug, an EC 2.3.3.8 (ATP citrate synthase) inhibitor and a prodrug.
ETC-1002 Preparation Products And Raw materials
Raw materials
Preparation Products
ETC-1002 Suppliers
View Lastest Price from ETC-1002 manufacturers
- Product
- Bempedoic Acid 738606-46-7
- Price
- US $0.00/KG
- Min. Order
- 25KG
- Purity
- 98%
- Supply Ability
- Inquiry
- Release date
- 2022-09-29
- Product
- Bempedoic acid 738606-46-7
- Price
- US $0.00/G
- Min. Order
- 1G
- Purity
- 98%min
- Supply Ability
- 30kg/month
- Release date
- 2023-02-02
- Product
- Bempedoic acid (ETC-1002) 738606-46-7
- Price
- US $0.00-0.00/kg
- Min. Order
- 1kg
- Purity
- 98%
- Supply Ability
- 1Ton
- Release date
- 2022-10-10