ChemicalBook > CAS DataBase List > 4-amino-1-((2R,3R,5S)-2-(hydroxymethyl)-3-oxido-1,3-oxathiolan-5-yl)pyrimidin-2(1H)-one

4-amino-1-((2R,3R,5S)-2-(hydroxymethyl)-3-oxido-1,3-oxathiolan-5-yl)pyrimidin-2(1H)-one

Product Name
4-amino-1-((2R,3R,5S)-2-(hydroxymethyl)-3-oxido-1,3-oxathiolan-5-yl)pyrimidin-2(1H)-one
CAS No.
160552-54-5
Chemical Name
4-amino-1-((2R,3R,5S)-2-(hydroxymethyl)-3-oxido-1,3-oxathiolan-5-yl)pyrimidin-2(1H)-one
Synonyms
GI138870X;GI 138870X;GI-138870X;Lamivudine EP IMP H;Lamivudine EP Impurity G;Lamivudine sulfoxide, (R)-;Lamivudine Impurity (R-sulphoxide);Lamivudine EP Impurity H / R Sulfoxide;Lamivudine Impurity 8(Lamivudine EP Impurity H);Lamivudine EP Impurity H (Lamivudine (3R)-Sulfoxide)
CBNumber
CB73051758
Molecular Formula
C8H11N3O4S
Formula Weight
245.26
MOL File
160552-54-5.mol
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4-amino-1-((2R,3R,5S)-2-(hydroxymethyl)-3-oxido-1,3-oxathiolan-5-yl)pyrimidin-2(1H)-one Property

Boiling point:
601.7±65.0 °C(Predicted)
Density 
1.93±0.1 g/cm3(Predicted)
solubility 
DMSO (Slightly, Heated), Water (Slightly, Heated, Sonicated)
pka
13.46±0.10(Predicted)
form 
Solid
color 
White to Off-White
Stability:
Hygroscopic
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

TRC
Product number
L172475
Product name
Lamivudine(R)-Sulfoxide
Packaging
10mg
Price
$180
Updated
2021/12/16
TRC
Product number
L172475
Product name
Lamivudine(R)-Sulfoxide
Packaging
100mg
Price
$1390
Updated
2021/12/16
AvaChem
Product number
3822
Product name
4-amino-1-[(2R,3R,5S)-2-(hydroxymethyl)-1,3-oxathiolan-5-yl]pyrimidin-2(1H)-on
Packaging
5mg
Price
$175
Updated
2021/12/16
AvaChem
Product number
3822
Product name
4-amino-1-[(2R,3R,5S)-2-(hydroxymethyl)-1,3-oxathiolan-5-yl]pyrimidin-2(1H)-on
Packaging
10mg
Price
$275
Updated
2021/12/16
AvaChem
Product number
3822
Product name
4-amino-1-[(2R,3R,5S)-2-(hydroxymethyl)-1,3-oxathiolan-5-yl]pyrimidin-2(1H)-on
Packaging
25mg
Price
$575
Updated
2021/12/16
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4-amino-1-((2R,3R,5S)-2-(hydroxymethyl)-3-oxido-1,3-oxathiolan-5-yl)pyrimidin-2(1H)-one Chemical Properties,Usage,Production

Uses

Lamivudine (R)-Sulfoxide (Lamivudine EP Impurity H) is a metabolite of Lamivudine (L172500); a potent nucleoside reverse transcriptase inhibitor and antiviral agent. Lamivudine has been used for treatment of chronic hepatitis B.

4-amino-1-((2R,3R,5S)-2-(hydroxymethyl)-3-oxido-1,3-oxathiolan-5-yl)pyrimidin-2(1H)-one Preparation Products And Raw materials

Raw materials

Preparation Products

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4-amino-1-((2R,3R,5S)-2-(hydroxymethyl)-3-oxido-1,3-oxathiolan-5-yl)pyrimidin-2(1H)-one Suppliers

China 48 India 11 United States 5 Global 64
Chemicea Pharmaceuticals Pvt Ltd
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160552-54-5, 4-amino-1-((2R,3R,5S)-2-(hydroxymethyl)-3-oxido-1,3-oxathiolan-5-yl)pyrimidin-2(1H)-oneRelated Search:

5'-Epi-LaMivudine Lamivudine Impurity 1 (2R-cis)-5-(4-aMino-2-oxo-1(2H)-pyriMidinyl)-1,3-oxathiolane-2-carboxylic Acid Uracil ent-LaMivudine Lamivudine EP Impurity B TROXACITABINE Cytosine lamivudine sulfoxide Salicylic acid Lamivudine Aids004768 Lamivudine EP Impurity A

  • 4-amino-1-((2R,3R,5S)-2-(hydroxymethyl)-3-oxido-1,3-oxathiolan-5-yl)pyrimidin-2(1H)-one
  • 4-amino-1-[(2R,3R,5S)-2-(hydroxymethyl)-1,3-oxathiolan-5-yl]pyrimidin-2(1H)-one-S-oxide
  • Lamivudine EP Impurity G
  • Lamivudine Impurity 8(Lamivudine EP Impurity H)
  • 2(1H)-Pyrimidinone,4-amino-1-[(2R,3R,5S)-2-(hydroxymethyl)-3-oxido-1,3-oxathiolan-5-yl]- (9CI)
  • 2(1H)-Pyrimidinone, 4-amino-1-[(2R,3R,5S)-2-(hydroxymethyl)-3-oxido-1,3-oxathiolan-5-yl]-
  • 4-Amino-1-[(2R,3R,5S)-2-(hydroxymethyl)-3-oxido-1,3-oxathiolan-5-yl]-2(1H)-pyrimidinone
  • Lamivudine EP Impurity H / R Sulfoxide
  • Lamivudine EP Impurity H (Lamivudine (3R)-Sulfoxide)
  • Lamivudine Impurit Ⅴ:4-amino-1-((2R,3R,5S)-2-(hydroxymethyl)-3-oxido-1,3-oxathiolan-5-yl)pyrimidin-2(1H)-one
  • Lamivudine Impurity Ⅴ 4-amino-1-[(2R,3R,5S)-2-(hydro xymethyl)-1,3-oxathiolan-5-yl] pyrimidin-2(1H)-one-S-oxide
  • GI 138870X
  • GI138870X
  • GI-138870X
  • Lamivudine sulfoxide, (R)-
  • Lamivudine EP IMP H
  • Lamivudine Impurity (R-sulphoxide)
  • 160552-54-5
  • 60552-55-6
  • 24526