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TROXACITABINE

Product Name
TROXACITABINE
CAS No.
145918-75-8
Chemical Name
TROXACITABINE
Synonyms
CS-150;L-Oddc;SPD 758;Bch 4556;(-)-Occc;Troxatyl;(-)-Bch 204;TROXACITABINE;α-L-Dioxolane-C;Lamivudine Impurity I
CBNumber
CB71011675
Molecular Formula
C8H11N3O4
Formula Weight
213.19
MOL File
145918-75-8.mol
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TROXACITABINE Property

Melting point:
176-177°
alpha 
D25 -38.33° (c = 0.43 in MeOH).
Boiling point:
422.5±55.0 °C(Predicted)
Density 
1.71±0.1 g/cm3(Predicted)
storage temp. 
2-8°C(protect from light)
solubility 
DMSO (Slightly), Methanol (Slightly)
form 
Solid
pka
14.83±0.10(Predicted)
color 
White to Off-White
Stability:
Hygroscopic
InChI
InChI=1S/C8H11N3O4/c9-5-1-2-11(8(13)10-5)6-4-14-7(3-12)15-6/h1-2,6-7,12H,3-4H2,(H2,9,10,13)/t6-,7-/m0/s1
InChIKey
RXRGZNYSEHTMHC-BQBZGAKWSA-N
SMILES
C1(=O)N([C@@H]2CO[C@H](CO)O2)C=CC(N)=N1
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

TRC
Product number
T805580
Product name
Troxacitabine
Packaging
0.5mg
Price
$335
Updated
2021/12/16
TRC
Product number
T805580
Product name
Troxacitabine
Packaging
2.5mg
Price
$1490
Updated
2021/12/16
Usbiological
Product number
296507
Product name
Troxacitabine
Packaging
10mg
Price
$3787
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
API0005342
Product name
TROXACITABINE
Purity
95.00%
Packaging
10MG
Price
$1067.22
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
API0005342
Product name
TROXACITABINE
Purity
95.00%
Packaging
1G
Price
$8805.3
Updated
2021/12/16
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TROXACITABINE Chemical Properties,Usage,Production

Uses

Troxacitabine is a nucleoside analogue with potential anticancer activity. Troxacitabine have been studied in patients with refractory lymphoproliferative diseases.

Definition

ChEBI: Troxacitabine is a nucleobase-containing molecular entity and a carbohydrate derivative.

in vivo

Troxacitabine is highly active against the Panc-01 model, with TGI levels of 88.5% and 84.3% at the 10 and 25 mg/kg doses, respectively. The mean final tumor weights for animals given troxacitabine are also significantly smaller compared with vehicle controls. Troxacitabine has less activity against the MiaPaCa model[3]. Troxacitabine is very effective in human RCC tumor xenograft models, including CAM-i, A498, RXF-393, and SN12C carcinomas. Very good responses are ob served in animals bearing CAM-i, A498, and RXF-393 RCC tumors given i.p. doses of 10, 25, and 50 mg/kg twice a day for 5 days[2].

TROXACITABINE Preparation Products And Raw materials

Raw materials

Preparation Products

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TROXACITABINE Suppliers

Canada 1 China 77 India 2 United States 12 Global 92
Hangzhou FuRun Pharmaceutical Technology Co., Ltd
Tel
15658004993
Email
1900830611@qq.com
Country
China
ProdList
980
Advantage
58
J & K SCIENTIFIC LTD.
Tel
18210857532; 18210857532
Fax
86-10-82849933
Email
jkinfo@jkchemical.com
Country
China
ProdList
96815
Advantage
76
Shanghai Sphchem Co., Ltd.
Tel
021-56491756 13512199871
Fax
021-5649-1756
Email
2819742715@qq.com
Country
China
ProdList
4000
Advantage
55
Beijing HuaMeiHuLiBiological Chemical
Tel
010-56205725
Fax
010-65763397
Email
waley188@sohu.com
Country
China
ProdList
12335
Advantage
58
AdooQ BioScience, LLC
Tel
+1 (866) 930-6790
Fax
+1 (866) 333-9607
Email
info@adooq.com
Country
United States
ProdList
2782
Advantage
58
ChemStrong Scientific Co.,Ltd
Tel
0755-0755-66853366 13670046396
Fax
0755-28363542
Email
sales@chem-strong.com
Country
China
ProdList
18333
Advantage
56
Shandong Boluoda Biological Technology Co., Ltd.
Tel
0531-68652053 15863796298;
Email
2310993908@qq.com
Country
China
ProdList
2437
Advantage
58
Shanghai Kewel Chemical Co., Ltd.
Tel
021-64609169 18901607656
Fax
021-64609160
Email
greensnown@163.com
Country
China
ProdList
9906
Advantage
50
Shanghai HuanChuan Industry Co.,Ltd.
Tel
021-61478794
Fax
021-61478794
Email
sales@hcshhai.com
Country
China
ProdList
9793
Advantage
50
Jiangsu Aikon Biopharmaceutical R&D co.,Ltd.
Tel
025-66028182 18626450290
Email
yftan@aikonchem.com
Country
China
ProdList
16679
Advantage
50
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View Lastest Price from TROXACITABINE manufacturers

Hangzhou Huarong Pharm Co., Ltd.
Product
4-amino-1-((2S,4S)-2-(hydroxymethyl)-1,3-dioxolan-4-yl)pyrimidin-2(1H)-one 145918-75-8
Price
US $0.00-0.00/mg
Min. Order
10mg
Purity
99%
Supply Ability
10KG
Release date
2021-09-17
Career Henan Chemical Co
Product
TROXACITABINE 145918-75-8
Price
US $1.00/KG
Min. Order
1KG
Purity
95--99%
Supply Ability
1ton
Release date
2020-01-03

145918-75-8, TROXACITABINERelated Search:

4-amino-1-((2R,3R,5S)-2-(hydroxymethyl)-3-oxido-1,3-oxathiolan-5-yl)pyrimidin-2(1H)-one Cytosine lamivudine sulfoxide Salicylic acid Lamivudine Aids004768 Lamivudine EP Impurity A lignocaine N-oxide 4-(HYDROXYMETHYL)BENZONITRILE (2R,5R)-5-Hydroxy-1,3-oxathiolane-2-carboxylic acid (1R,2S,5R)-5-methyl-2-(1-methylethyl)cyclohexyl ester Lamivudine Impurity 9 Lamivudine impurity 6 (1r,2s,5r)-2-Isopropyl-5-Methylcyclohexyl-5-Hydroxy-1,3oxathiolane-2-Carboxylate Gemcitabine Antazoline Uracil ent-LaMivudine Lamivudine EP Impurity B

  • TROXACITABINE
  • TROXACITABINE,2(1H)-PYRIMIDINONE, 4-AMINO-1-(2-(HYDROXYMETHYL)-1,3-DIOXOLAN-4-YL)-, (2S-CIS)-
  • 4-Amino-1-[(2S)-2-(hydroxymethyl)-1,3-dioxolan-4-yl]pyrimidin-2-one
  • (-)-Bch 204
  • CS-150
  • Lamivudine Impurity I (Troxacitabine)
  • 4-amino-1-[(2S,4S)-2-(hydroxymethyl)-1,3-dioxolan-4-yl]-1,2-dihydropyrimidin-2-one
  • (-)-Occc
  • 2(1H)-Pyrimidinone, 4-amino-1-((2S,4S)-2-(hydroxymethyl)-1,3-dioxolan-4-yl)-
  • 2(1H)-Pyrimidinone, 4-amino-1-(-2-(hydroxymethyl)-1,3-dioxolan-4-yl)-, (2S-cis)-
  • Bch 4556
  • L-Oddc
  • Troxatyl
  • Troxacitabine (SGX-145)
  • SPD 758
  • α-L-Dioxolane-C
  • Lamivudine Impurity I
  • 4-amino-1-((2S,4S)-2-(hydroxymethyl)-1,3-dioxolan-4-yl)pyrimidin-2(1H)-one
  • Lamivudine EP Impurity I
  • Lamivudine EP Impurity I (Troxacitabine)
  • Troxacitabine(BCH4556)
  • 4-amino-1-((2RS,4RS)-2-(hydroxymethyl)-1,3-dioxolan-4-yl)pyrimidin-2(1H)-one
  • 4-amino-1-(2-(hydroxymethyl)-1,3-dioxolan-4-yl)pyrimidin-2(1H)-one
  • 145918-75-8