ChemicalBook > CAS DataBase List > 4-Methylmorpholine N-oxide

4-Methylmorpholine N-oxide

Product Name
4-Methylmorpholine N-oxide
CAS No.
7529-22-8
Chemical Name
4-Methylmorpholine N-oxide
Synonyms
NMO;4-METHYLMORPHOLINE 4-OXIDE;N-Methylmorpholine oxide;Morpholine, 4-methyl-, 4-oxide;4-methyl-morpholin4-oxide;MMNO;NSC 73198;NSC 82153;ine N-oxide;nmo solution
CBNumber
CB7305470
Molecular Formula
C5H11NO2
Formula Weight
117.15
MOL File
7529-22-8.mol
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4-Methylmorpholine N-oxide Property

Melting point:
180-184 °C(lit.)
Boiling point:
118-119°C
Density 
1,14 g/cm3
vapor pressure 
1.41hPa at 20℃
refractive index 
n20/D 1.43
Flash point:
118-119°C
storage temp. 
2-8°C
solubility 
DMSO (Soluble), Methanol (Slightly)
form 
Liquid
pka
4.93±0.20(Predicted)
color 
Clear colorless to yellow
PH
9.00 ( in neat)
Water Solubility 
Soluble in water, methanol, ethanol, acetone, ethers and dimethylsulfoxide.
BRN 
507437
Stability:
Hygroscopic
LogP
-1.2 at 25℃
CAS DataBase Reference
7529-22-8(CAS DataBase Reference)
NIST Chemistry Reference
N-Methylmorpholine-N-oxide(7529-22-8)
EPA Substance Registry System
Morpholine, 4-methyl-, 4-oxide (7529-22-8)
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Safety

Hazard Codes 
Xi
Risk Statements 
36/37/38
Safety Statements 
26-36/37
WGK Germany 
1
TSCA 
Yes
HS Code 
29349990
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H228Flammable solid

H272May intensify fire; oxidizer

Precautionary statements

P202Do not handle until all safety precautions have been read and understood.

P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.

P220Keep/Store away from clothing/…/combustible materials.

P240Ground/bond container and receiving equipment.

P241Use explosion-proof electrical/ventilating/lighting/…/equipment.

P308+P313IF exposed or concerned: Get medical advice/attention.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
8.14779
Product name
4-Methylmorpholine 4-oxide
Purity
(50% solution in water) for synthesis
Packaging
250ML
Price
$53.7
Updated
2024/03/01
Sigma-Aldrich
Product number
8.14779
Product name
4-Methylmorpholine 4-oxide
Purity
(50% solution in water) for synthesis
Packaging
1L
Price
$168
Updated
2024/03/01
Sigma-Aldrich
Product number
224286
Product name
4-Methylmorpholine N-oxide
Purity
97%
Packaging
5g
Price
$55.3
Updated
2024/03/01
Sigma-Aldrich
Product number
224286
Product name
4-Methylmorpholine N-oxide
Purity
97%
Packaging
25g
Price
$149
Updated
2024/03/01
TCI Chemical
Product number
M0981
Product name
4-Methylmorpholine N-Oxide (50% in Water, ca. 4.8mol/L)
Packaging
25mL
Price
$18
Updated
2024/03/01
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4-Methylmorpholine N-oxide Chemical Properties,Usage,Production

Chemical Properties

Clear colorless to yellow solution

Uses

4-Methylmorpholine N-Oxide is a metabolite of Morpholine (M723725). N-Methylmorpholine N-Oxide is commonly used to dissolve cellulose as well as in the dissolution of of scleroproteins.

Uses

4-Methylmorpholine N-oxide acts as a non-metallic catalyst for the cyanosilylation of ketones. It is also employed as a co-oxidant for Sharpless asymmetric dihydroxylation in ionic liquids. It serves as a solvent in the Lyocell process to produce tencel fiber. Further, it is used in the preparation of aldehydes from primary alcohols in the presence of tetrapropylammonium perruthenate.

Uses

Non-metallic catalyst for the cyanosilylation of ketones. Co-oxidant for Sharpless asymmetric dihydroxylation in ionic liquids.

Definition

ChEBI: N-methylmorpholine N-oxide is a morpholine N-oxide resulting from the oxidation of the amino group of N-methylmorpholine.

General Description

4-Methylmorpholine?N-oxide is an organic compound used as a co-oxidant along with OsO4 and ruthenates in organic synthesis. In recent studies, it has been used as a catalyst in silylcyanation of aldehydes and ketones. Lyocell, a regenerated cellulose fiber, can be prepared using 4-methylmorpholine?N-oxide in an eco-friendly manner.

Flammability and Explosibility

Flammable

reaction suitability

reagent type: oxidant

Synthesis

A preparation method of N-methylmorpholine-N-oxide comprises the following steps: (1) adding the nano metal oxide into N-methyl morpholine (NMM) and mixing and stirring to uniformly mix the nano metal oxide with the NMM; (2) dropwise adding a hydrogen peroxide solution into a mixed solution of NMM and a catalyst; (3) raising the temperature to accelerate the reaction process; (4) and (4) filtering and distilling the solution prepared in the step (3) under reduced pressure to obtain the required NMMO solution. The method for preparing NMMO provided by the present disclosure has the advantages of a fast reaction rate, low reaction temperature, few byproducts, etc.

Purification Methods

When the oxide is dried for 2-3hours at high vacuum, it dehydrates. Add MeOH to the oxide and distil off the solvent under vacuum until the temperature is ca 95o. Then add Me2CO at reflux and cool to 20o. The crystals are filtered off, washed with Me2CO and dried. The degree of hydration may vary and may be important for the desired reactions. [van Rheenan et al. Tetrahedron Lett 1973 1076, Schneider & Hanze US Pat 2 769 823; see also Sharpless et al. Tetrahedron Lett 2503 1976.]

4-Methylmorpholine N-oxide Preparation Products And Raw materials

Raw materials

Preparation Products

4-METHYL-2-OXO-2 H-CHROMENE-7-CARBALDEHYDE 4-Methylmorpholine N-oxide monohydrate
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4-Methylmorpholine N-oxide Suppliers

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View Lastest Price from 4-Methylmorpholine N-oxide manufacturers

Hebei Zhuanglai Chemical Trading Co.,Ltd
Product
4-Methylmorpholine-N-oxide 7529-22-8
Price
US $60.00/kg
Min. Order
1kg
Purity
99
Supply Ability
5000
Release date
2024-05-06
Hebei Mujin Biotechnology Co.,Ltd
Product
4-Methylmorpholine N-oxide 7529-22-8
Price
US $0.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
50000KG/month
Release date
2023-06-29
Hebei Weibang Biotechnology Co., Ltd
Product
4-Methylmorpholine N-oxide 7529-22-8
Price
US $0.00-0.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
10 mt
Release date
2024-12-09

7529-22-8, 4-Methylmorpholine N-oxideRelated Search:

Iron oxide Boron oxide Tribenuron methyl Methyl acrylate Tridemorph Moroxydine ETHYLENE OXIDE Kresoxim-methyl Methanol Methylparaben Moroxydine hydrochloride Iron oxide black 4-Methylmorpholine Rutile NITRIC OXIDE N-Formylmorpholine 2,2,6,6-Tetramethylpiperidinooxy Methyl salicylate

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  • 4-Methylmorpholine N-Oxide (50% in Water, ca. 4.8mol/L)
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  • Morpholine, 4-methyl-, 4-oxide hydrate
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