ChemicalBook > CAS DataBase List > GSK-A1

GSK-A1

Product Name: GSK-A1
CAS No.: 1416334-69-4
Chemical Name: GSK-A1
Synonyms: GSK-A1;PI4KA inhibitor-A1;5-{2-Amino-1-[4-(4-morpholinyl)phenyl]-1H-benzimidazol-6-yl}-N-(2-fluorophenyl)-2-methoxy-3-pyridinesulfonamide;3-Pyridinesulfonamide, 5-[2-amino-1-[4-(4-morpholinyl)phenyl]-1H-benzimidazol-6-yl]-N-(2-fluorophenyl)-2-methoxy-;PtdIns(4,5)P2,PI4KIIIα,inhibit,Hepatitis C virus,PI4K,GSK A1,GSK-A1,Phosphatidylinositol 4 kinases,PtdIns(4)P,phosphatidylinositol 4-kinase PI4KA,HCV,Inhibitor,PI4 kinases,GSKA1,GSK-A-1
CBNumber: CB73067551
Molecular Formula: C29H27FN6O4S
Formula Weight: 574.63
MOL File: 1416334-69-4.mol

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GSK-A1 Property

storage temp.: Store at -20°C
solubility: DMSO: 2 mg/ml
form: A solid
color: White to off-white

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Adipogen Life Sciences

Product number: SYN-1219-M001
Product name: GSK-A1
Purity: ≥95%
Packaging: 1mg
Price: $130
Updated: 2021/12/16

AK Scientific

Product number: SYN1219
Product name: GSK-A1
Packaging: 50mg
Price: $1270
Updated: 2021/12/16

DC Chemicals

Product number: DC10061
Product name: PI4KAinhibitor-A1
Purity: >98%
Packaging: 250mg
Price: $1300
Updated: 2021/12/16

DC Chemicals

Product number: DC10061
Product name: PI4KAinhibitor-A1
Purity: >98%
Packaging: 1g
Price: $2700
Updated: 2021/12/16

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GSK-A1 Chemical Properties,Usage,Production

Uses

GSK-A1 is a selective type III phosphatidylinositol 4-kinase PI4KA (PI4KIIIα) inhibitor with a pIC50 of 8.5-9.8. GSK-A1 inhibits PtdIns(4,5)P2 resynthesis with an IC50 of about 3 nM. GSK-A1 potently decreases the levels of PtdIns(4)P with a negligible effect on PtdIns(4,5)P2. GSK-A1 has?the?potential?for?anti-hepatitis C virus (HCV) research[1].

Biological Activity

GSK-A1 is an inhibitor of phosphatidylinositol 4-kinase IIIα (PI4KIIIα; IC50 = 3.16 nM).1 It is selective for PI4KIIIα over PI4KIIIβ, PI3Kα, PI3Kβ, and PI3Kδ (IC50s = >50 nM) but also inhibits PI3Kγ (IC50 = 15.8 nM). GSK-A1 decreases the levels of phosphatidylinositol 4-phosphate (PtdIns-(4)-P1) but not PtdIns-(4,5)-P2 in HEK293 cells expressing the angiotensin II type 1 (AT1) receptor (IC50 = 3 nM). GSK-A1 inhibits hepatitis C virus (HCV) genotype 1a and 1b replication.

IC 50

PI4KA: 8.5-9.8 (pIC₅₀); PI4KB: 7.2-7.7 (pIC₅₀); PI4K2A: <5 (pIC₅₀); PI4K2B: <5 (pIC₅₀)

References

1.Bojjireddy, N., Botyanszki, J., Hammond, G., et al.Pharmacological and genetic targeting of the PI4KA enzyme reveals its important role in maintaining plasma membrane phosphatidylinositol 4-phosphate and phosphatidylinositol 4,5-bisphosphate levelsJ. Biol. Chem.289(9)6120-6132(2014)

GSK-A1 Preparation Products And Raw materials

Raw materials

Preparation Products

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GSK-A1 Suppliers

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1416334-69-4, GSK-A1Related Search:

GSK2837808A GSK6853 S)-1-(sec-butyl)-N-((4,6-diMethyl-2-oxo-1,2-dihydropyridin-3-yl)Methyl)-3-Methyl-6-(6-(piperazin-1-yl)pyridin-3-yl)-1H-indole-4-carboxaMide GSK864 GSK484 GSK J4 HCl GSK 2334470 GSK2982772 GSK2636771 Benzeneacetamide, α-[[6-(4-amino-1-piperidinyl)-3,5-dicyano-4-ethyl-2-pyridinyl]thio]- GSK778 N-(6-Fluoro-1H-indazol-5-yl)-2-methyl-6-oxo-4-[4-(trifluoromethyl)phenyl]-1,4,5,6-tetrahydro-3-pyridinecarboxamide GSK 2033 2-((4-(benzo[d]thiazol-5-ylamino)-6-(tert-butylsulfonyl)quinazolin-7-yl)oxy)ethyl dihydrogen phosphate N-((S)-1-(4-((S)-2-(2,4-dichlorophenylsulfonaMido)-3-hydroxypropanoyl)piperazin-1-yl)-4-Methyl-1-oxopentan-2-yl)benzo[b]thiophene-2-carboxaMide GSK-2256098 GSK215

GSK-A1

PI4KA inhibitor-A1

3-Pyridinesulfonamide, 5-[2-amino-1-[4-(4-morpholinyl)phenyl]-1H-benzimidazol-6-yl]-N-(2-fluorophenyl)-2-methoxy-

5-{2-Amino-1-[4-(4-morpholinyl)phenyl]-1H-benzimidazol-6-yl}-N-(2-fluorophenyl)-2-methoxy-3-pyridinesulfonamide

PtdIns(4,5)P2,PI4KIIIα,inhibit,Hepatitis C virus,PI4K,GSK A1,GSK-A1,Phosphatidylinositol 4 kinases,PtdIns(4)P,phosphatidylinositol 4-kinase PI4KA,HCV,Inhibitor,PI4 kinases,GSKA1,GSK-A-1

1416334-69-4

C29H27FN6O4S