GSK-A1

Product Name: GSK-A1
CAS No.: 1416334-69-4
Chemical Name: GSK-A1
Synonyms: GSK-A1;PI4KA inhibitor-A1;5-{2-Amino-1-[4-(4-morpholinyl)phenyl]-1H-benzimidazol-6-yl}-N-(2-fluorophenyl)-2-methoxy-3-pyridinesulfonamide;3-Pyridinesulfonamide, 5-[2-amino-1-[4-(4-morpholinyl)phenyl]-1H-benzimidazol-6-yl]-N-(2-fluorophenyl)-2-methoxy-;PtdIns(4,5)P2,PI4KIIIα,inhibit,Hepatitis C virus,PI4K,GSK A1,GSK-A1,Phosphatidylinositol 4 kinases,PtdIns(4)P,phosphatidylinositol 4-kinase PI4KA,HCV,Inhibitor,PI4 kinases,GSKA1,GSK-A-1
CBNumber: CB73067551
Molecular Formula: C29H27FN6O4S
Formula Weight: 574.63
MOL File: 1416334-69-4.mol

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GSK-A1 Property

storage temp.: Store at -20°C
solubility: DMSO: 2 mg/ml
form: A solid
color: White to off-white

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Adipogen Life Sciences

Product number: SYN-1219-M001
Product name: GSK-A1
Purity: ≥95%
Packaging: 1mg
Price: $130
Updated: 2021/12/16

AK Scientific

Product number: SYN1219
Product name: GSK-A1
Packaging: 50mg
Price: $1270
Updated: 2021/12/16

DC Chemicals

Product number: DC10061
Product name: PI4KAinhibitor-A1
Purity: >98%
Packaging: 250mg
Price: $1300
Updated: 2021/12/16

DC Chemicals

Product number: DC10061
Product name: PI4KAinhibitor-A1
Purity: >98%
Packaging: 1g
Price: $2700
Updated: 2021/12/16

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GSK-A1 Chemical Properties,Usage,Production

Biological Activity

GSK-A1 is an inhibitor of phosphatidylinositol 4-kinase IIIα (PI4KIIIα; IC50 = 3.16 nM).1 It is selective for PI4KIIIα over PI4KIIIβ, PI3Kα, PI3Kβ, and PI3Kδ (IC50s = >50 nM) but also inhibits PI3Kγ (IC50 = 15.8 nM). GSK-A1 decreases the levels of phosphatidylinositol 4-phosphate (PtdIns-(4)-P1) but not PtdIns-(4,5)-P2 in HEK293 cells expressing the angiotensin II type 1 (AT1) receptor (IC50 = 3 nM). GSK-A1 inhibits hepatitis C virus (HCV) genotype 1a and 1b replication.

References

1.Bojjireddy, N., Botyanszki, J., Hammond, G., et al.Pharmacological and genetic targeting of the PI4KA enzyme reveals its important role in maintaining plasma membrane phosphatidylinositol 4-phosphate and phosphatidylinositol 4,5-bisphosphate levelsJ. Biol. Chem.289(9)6120-6132(2014)

GSK-A1 Preparation Products And Raw materials

Raw materials

Preparation Products

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GSK-A1 Suppliers

China 33 United Kingdom 1 United States 3 Global 37

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1416334-69-4, GSK-A1Related Search:

GSK2837808A GSK6853 S)-1-(sec-butyl)-N-((4,6-diMethyl-2-oxo-1,2-dihydropyridin-3-yl)Methyl)-3-Methyl-6-(6-(piperazin-1-yl)pyridin-3-yl)-1H-indole-4-carboxaMide GSK864 GSK484 GSK J4 HCl GSK 2334470 GSK2982772 GSK2636771 Benzeneacetamide, α-[[6-(4-amino-1-piperidinyl)-3,5-dicyano-4-ethyl-2-pyridinyl]thio]- GSK778 N-(6-Fluoro-1H-indazol-5-yl)-2-methyl-6-oxo-4-[4-(trifluoromethyl)phenyl]-1,4,5,6-tetrahydro-3-pyridinecarboxamide GSK 2033 2-((4-(benzo[d]thiazol-5-ylamino)-6-(tert-butylsulfonyl)quinazolin-7-yl)oxy)ethyl dihydrogen phosphate N-((S)-1-(4-((S)-2-(2,4-dichlorophenylsulfonaMido)-3-hydroxypropanoyl)piperazin-1-yl)-4-Methyl-1-oxopentan-2-yl)benzo[b]thiophene-2-carboxaMide GSK-2256098 GSK215

GSK-A1

PI4KA inhibitor-A1

3-Pyridinesulfonamide, 5-[2-amino-1-[4-(4-morpholinyl)phenyl]-1H-benzimidazol-6-yl]-N-(2-fluorophenyl)-2-methoxy-

5-{2-Amino-1-[4-(4-morpholinyl)phenyl]-1H-benzimidazol-6-yl}-N-(2-fluorophenyl)-2-methoxy-3-pyridinesulfonamide

PtdIns(4,5)P2,PI4KIIIα,inhibit,Hepatitis C virus,PI4K,GSK A1,GSK-A1,Phosphatidylinositol 4 kinases,PtdIns(4)P,phosphatidylinositol 4-kinase PI4KA,HCV,Inhibitor,PI4 kinases,GSKA1,GSK-A-1

1416334-69-4

C29H27FN6O4S