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Carbenicillin disodium

Product Name
Carbenicillin disodium
CAS No.
4800-94-6
Chemical Name
Carbenicillin disodium
Synonyms
geopen;pyopen;piopen;hyoper;pyopene;gripenin;Carbapen;brl-2064;carbecin;ANABACTYL
CBNumber
CB7308325
Molecular Formula
C17H19N2NaO6S
Formula Weight
402.4
MOL File
4800-94-6.mol
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Carbenicillin disodium Property

Melting point:
>190°C (dec.)
alpha 
+175～+190°(D/20℃)(c=4,H2O)(calculated on the dehydrous basis)
storage temp. 
Inert atmosphere,2-8°C
solubility 
H2O: 50 mg/mL
form 
powder
color 
white to off-white
PH
5.5～7.5 (10g/l, 25℃)
Water Solubility 
Soluble in water.
Merck 
13,1801
BRN 
5722128
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Safety

Hazard Codes 
Xn
Risk Statements 
42/43
Safety Statements 
22-36/37-36
RIDADR 
UN 1170 3/PG 3
WGK Germany 
2
RTECS 
ON9105000
F 
3-8-10
HS Code 
29411000
Toxicity
LD50 i.p. in rats: >2000 mg/kg (Goldenthal)
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H317May cause an allergic skin reaction

H334May cause allergy or asthma symptoms or breathing difficulties if inhaled

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P272Contaminated work clothing should not be allowed out of the workplace.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P284Wear respiratory protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P333+P313IF SKIN irritation or rash occurs: Get medical advice/attention.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
C1389
Product name
Carbenicillin disodium salt
Purity
89.0-100.5% anhydrous basis
Packaging
1g
Price
$130
Updated
2024/03/01
Sigma-Aldrich
Product number
C1389
Product name
Carbenicillin disodium salt
Purity
89.0-100.5% anhydrous basis
Packaging
5g
Price
$449
Updated
2024/03/01
Alfa Aesar
Product number
J61949
Product name
Carbenicillin disodium salt
Packaging
1g
Price
$94.1
Updated
2024/03/01
Alfa Aesar
Product number
J61949
Product name
Carbenicillin disodium salt
Packaging
5g
Price
$277
Updated
2024/03/01
Cayman Chemical
Product number
20871
Product name
Carbenicillin (sodium salt)
Packaging
5g
Price
$81
Updated
2024/03/01
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Carbenicillin disodium Chemical Properties,Usage,Production

Description

Carbenicillin is a broad-spectrum carboxypenicillin antibiotic. It is active against Gram-negative and certain Gram-positive bacteria, including S. pyogenes, S. epidermidis, P. mirabilis, P. vulgaris, E. coli, and P. aeruginosa (MICs = 0.19, 1.56, 1.56, 3.12, 3.12, and 50 μg/ml, respectively). It is also active against penicillinase-producing and non-producing strains of S. aureus (MICs = 1.56 and 12.5 μg/ml, respectively). Carbenicillin is protective against systemic S. pyogenes, P. vulgaris, E. coli, and S. aureus infection in a mouse model of systemic lethal infection with 50% protective dose (PD50) values of 7.8, 224, 19.3, and 34 mg/kg, respectively. It also decreases viable colony counts in the kidney in a rat model of P. vulgaris or E. coli urinary tract infection when administered at a dose of 100 mg/kg. Formulations containing carbenicillin have previously been used in the treatment of upper and lower urinary tract infections and prostatitis.

Chemical Properties

white Powder

Originator

Pyopen,Beecham,Switz.,1968

Uses

Carbenicillin disodium salt is a water-soluble antibiotic which is effective against gram-negative bacteria.Carbenicillin disodium salt is widely utilized as an antibiotic which is used to control bacterial cell-wall synthesis by inactivating transpeptidases on the inner surface of the bacterial cell membrane. It has been involved in the study of the role of penicillin-sensitive transpeptidases in cell wall biosynthesis.

Uses

Semi-synthetic antibiotic related to Penicillin (P223500). Antibacterial.

Definition

ChEBI: Carbenicillin disodium is an organic sodium salt. It contains a carbenicillin(2-).

Manufacturing Process

The required monobenzyl phenylmalonate, MP 68°C, was prepared by treating a mixture of phenylmalonic acid (18 g) and benzyl alcohol (13 g) in carbon tetrachloride (80 ml) with dry hydrogen chloride.
Monobenzyl phenylmalonate (13.3 g) in dry benzene (100 ml) was refluxed with thionyl chloride (6.45 g) for 90 minutes, then concentrated in vacuo. The residual oil was dissolved in dry acetone (50 ml) and added to a stirred, ice-cooled solution of 6-aminopenicillanic acid (9.7 g) in N sodium bicarbonate solution (135 ml), water (150 ml), and acetone (300 ml). The mixture was stirred for 30 minutes at 0°C and then for 90 minutes at room temperature, then concentrated under reduced pressure to remove acetone. The aqueous solution was brought to pH 2 with dilute hydrochloric acid and extracted with ether (3 x 100 ml). The ether solution was washed with water and then itself extracted with sufficient N sodium bicarbonate solution to give an aqueous phase of pH 7.5. The aqueous layer was separated and evaporated at low temperature and pressure to leave the impure sodium salt of alpha- (benzyloxycarbonyl) benzylpenicillin.
This crude product (15.8 g) in water (360 ml) was added to a prehydrogenated suspension of 10% palladium on charcoal (4 g) in water (400 ml), and hydrogenation was continued for 30 minutes. The catalyst was removed and the filtrate was adjusted to pH 7.5 with sodium bicarbonate, then evaporated at low temperature and pressure. The residue was purified by chromatography on a column of cellulose powder, eluting first with butanol/ethanol/water mixture and then with acetone/isopropanol/water. The main fraction was evaporated at low temperature and pressure to give a 32% yield of the sodium salt of alpha-carboxybenzylpenicillin as a white powder. The product was estimated by monometric assay with penicillinase to be 58% pure.

brand name

Geopen (Roerig); Pyopen (GlaxoSmithKline).

Therapeutic Function

Antibacterial

General Description

Carbenicillin was synthesized by Brain et al. of Beecham Research Laboratories in 1965. It was the first synthetic penicillin to show activity against Pseudomonas aeruginosa. Although its activity against the microorganism is not strong (MIC = 25 – 100 μg/mL), it is widely used against P. aeruginosa infections because of its low toxicity and the lack of other antibiotics suitable for use against this microorganism. Carbenicillin is mainly used clinically to treat urinary tract and respiratory tract infections and sepsis caused by Proteus, Escherichia coli, Klebsiella, and Pseudomonas aeruginosa.

Clinical Use

Carbenicillin disodium, disodium α-carboxybenzylpenicillin(Geopen, Pyopen), is a semisynthetic penicillin releasedin the United States in 1970, which was introduced inEngland and first reported by Ancred et al. in 1967.Examination of its structure shows that it differs from ampicillinin having an ionizable carboxyl group rather than anamino group substituted on the α-carbon atom of the benzylside chain. Carbenicillin has a broad range of antimicrobialactivity, broader than any other known penicillin, a propertyattributed to the unique carboxyl group. It has been proposedthat the carboxyl group improves penetration of themolecule through cell wall barriers of Gram-negativebacilli, compared with other penicillins.
Carbenicillin is not stable in acids and is inactivated bypenicillinase. It is a malonic acid derivative and, as such, decarboxylatesreadily to penicillin G, which is acid labile.Solutions of the disodium salt should be freshly prepared but,when refrigerated, may be kept for 2 weeks. It must be administeredby injection and is usually given intravenously.
Carbenicillin has been effective in the treatment of systemicand urinary tract infections caused by P. aeruginosa,indole-producing Proteus spp., and Providencia spp., all ofwhich are resistant to ampicillin. The low toxicity of carbenicillin,with the exception of allergic sensitivity, permits theuse of large dosages in serious infections. Most cliniciansprefer to use a combination of carbenicillin and gentamicinfor serious pseudomonal and mixed coliform infections. Thetwo antibiotics are chemically incompatible, however, andshould never be combined in an intravenous solution.

Carbenicillin disodium Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from Carbenicillin disodium manufacturers

Hebei Weibang Biotechnology Co., Ltd
Product
Carbenicillin disodium 4800-94-6
Price
US $1.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
10 mt
Release date
2024-11-20
Hebei Chuanghai Biotechnology Co,.LTD
Product
Carbenicillin disodium 4800-94-6
Price
US $10.50/KG
Min. Order
1KG
Purity
99%
Supply Ability
1 ton
Release date
2024-08-21
Hebei Mojin Biotechnology Co., Ltd
Product
Carbenicillin disodium 4800-94-6
Price
US $0.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
50000KG/month
Release date
2023-08-30

4800-94-6, Carbenicillin disodiumRelated Search:

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  • (2S,5R,6R)-6-[(2-Carboxy-2-phenylacetyl)amino]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid disodium salt
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