ON123300

Product Name: ON123300
CAS No.: 1357470-29-1
Chemical Name: ON123300
Synonyms: 123300;CS-2199;ON123300;Narazaciclib;ON 123300; ON-123300;Narazaciclib ON 123300;ON 123300;ON-123300;ON123300;8-cyclopentyl-2-((4-(4-methylpiperazin-1-yl)phenyl)amino)-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile;8-Cyclopentyl-7,8-dihydro-2-[[4-(4-methyl-1-piperazinyl)phenyl]amino]-7-oxo-pyrido[2,3-d]pyrimidine-6-carbonitrile;Pyrido[2,3-d]pyrimidine-6-carbonitrile, 8-cyclopentyl-7,8-dihydro-2-[[4-(4-methyl-1-piperazinyl)phenyl]amino]-7-oxo-
CBNumber: CB73110758
Molecular Formula: C24H27N7O
Formula Weight: 429.52
MOL File: 1357470-29-1.mol

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ON123300 Property

Boiling point:: 642.7±65.0 °C(Predicted)
Density: 1.35±0.1 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: ≥21.5 mg/mL in DMSO with gentle warming; insoluble in EtOH; insoluble in H2O
form: solid
pka: 7.88±0.42(Predicted)
color: Yellow to orange

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 19902
Product name: ON-123300
Packaging: 1mg
Price: $37
Updated: 2024/03/01

Cayman Chemical

Product number: 19902
Product name: ON-123300
Packaging: 5mg
Price: $161
Updated: 2024/03/01

Cayman Chemical

Product number: 19902
Product name: ON-123300
Packaging: 10mg
Price: $283
Updated: 2024/03/01

Cayman Chemical

Product number: 19902
Product name: ON-123300
Packaging: 25mg
Price: $530
Updated: 2024/03/01

TRC

Product number: O658005
Product name: ON123300
Packaging: 10mg
Price: $360
Updated: 2021/12/16

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ON123300 Chemical Properties,Usage,Production

Uses

ON123300 is a potent multikinase inhibitor and may be potential useful for brain tumor chemotherapy. ON123300 strongly inhibits Ark5 and CDK4, as well as growth factor receptor tyrosine kinases.

Biological Activity

on123300 is a multi-targeted kinase inhibitor.the signaling hyperactivation of rtk is most commonly caused by egfr mutation/amplification or pdgfr amplification/overexpression. fgfr1signaling also occurs in gbm exhibiting fgfr1 kinase domain gain-of-function mutations.

in vitro

in previous study, when z138c and granta 519 cells were treated with on123300, it was found that on123300 was efficient to inhibit the phosphorylation of rb family proteins. moreover, on123300 was able to inhibit the phosphorylation of proteins that were involved in the pi3k/akt pathway. in addition, on123300-treated cells similarly arrested at lower concentrations, however, higher concentrations could lead to the apoptosis induction [1].

in vivo

previous animal in vivo study showed that mouse xenograft had a strong inhibition of mcl tumor growth in on123300-treated animals. moreover, the treatment with on123300 to ibrutinib-sensitive and -resistant patient-derived mcls was able to trigger apoptosis and inhibition of both rb and pi3k/akt pathways, indicating that on123300 could be an effective drug in the treatment of mcl, such as ibrutinib-resistant forms of the disease [1].

IC 50

3.9, 5, 26, 26, 9.2 and 11 nm for cdk4, ark5, pdgfrβ, fgfr1, ret, and fyn, respectively.

References

[1] divakar sk et al. dual inhibition of cdk4/rb and pi3k/akt/mtor pathways by on123300 induces synthetic lethality in mantle cell lymphomas. leukemia. 2016 jan;30(1):86-93.

ON123300 Preparation Products And Raw materials

Raw materials

Preparation Products

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ON123300 Suppliers

China 85 India 1 United States 9 Global 95

Musechem

Tel: +1-800-259-7612
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Email: info@musechem.com
Country: United States
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TargetMol Chemicals Inc.

Tel: +1-781-999-5354 +1-00000000000
Email: marketing@targetmol.com
Country: United States
ProdList: 32161
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InvivoChem

Tel: +1-708-310-1919 +1-13798911105
Fax: 708-557-7486
Email: sales@invivochem.cn
Country: United States
ProdList: 6391
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Cckinase, Inc.

Tel: +1 (732)236-3202
Email: sales@cckinase.com
Country: United States
ProdList: 2738
Advantage: 58

Aladdin Scientific

Tel: +1-+1(833)-552-7181
Email: sales@aladdinsci.com
Country: United States
ProdList: 57505
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TargetMol Chemicals Inc.

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ApexBio Technology

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BOC Sciences

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Cayman Chemical Company

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1357470-29-1, ON123300Related Search:

ON1231320 Sodium cyanoborohydride CYCLOPENTYLBENZENE Glycolic acid

8-Cyclopentyl-7,8-dihydro-2-[[4-(4-methyl-1-piperazinyl)phenyl]amino]-7-oxo-pyrido[2,3-d]pyrimidine-6-carbonitrile

123300

8-cyclopentyl-2-((4-(4-methylpiperazin-1-yl)phenyl)amino)-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile

ON123300

CS-2199

ON 123300;ON-123300;ON123300

ON 123300; ON-123300

Pyrido[2,3-d]pyrimidine-6-carbonitrile, 8-cyclopentyl-7,8-dihydro-2-[[4-(4-methyl-1-piperazinyl)phenyl]amino]-7-oxo-

Narazaciclib ON 123300

Narazaciclib

Platelet-derived growth factor receptor,AMP-activated protein kinase,ON-123300,ON 123300,FGFR1,kinase,brain,CDK,Ark5,U87,inhibit,PDGFR,multi,RET,tumor,Inhibitor,glioma,Cyclin dependent kinase,AMPK,CDK4,FYN,RTK,penetration,ON123300,PDGFRβ,CDK6

1357470-29-1