Scopolamine Hydrobromide Trihydrate

Product Name: Scopolamine Hydrobromide Trihydrate
CAS No.: 6533-68-2
Chemical Name: Scopolamine Hydrobromide Trihydrate
Synonyms: screen;tripton;Benzeneacetic acid, .alpha.-(hydroxymethyl)-, (1.alpha.,2.beta.,4.beta.,5.alpha.,7.beta.)-9-methyl-3-oxa-9-azatricyclo3.3.1.02,4non-7-yl ester, hydrobromide, trihydrate, (.alpha.S)-;C17H21NO4BRH3H2O;Scopolamine CRS.;Scopolamine-d3.HBr;Tiotropium Impurity 21;),hydrobromide,trihydrate;East pol base hydrobromide;Scopolamine Hydrobromide RS
CBNumber: CB7311132
Molecular Formula: C17H24BrNO5
Formula Weight: 402.29
MOL File: 6533-68-2.mol

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Scopolamine Hydrobromide Trihydrate Property

Melting point:: 197-194 °C
refractive index: -25.5 ° (C=5, H2O)
storage temp.: Poison room
solubility: H2O: soluble50mg/mL
form: Crystals or Crystalline Powder
color: white to off-white
optical activity: [α]25/D 24 to 26°, c = 5 in H2O(lit.)
Water Solubility: H2O: 50mg/mL
Merck: 14,8406
BRN: 6100669
Stability:: Stable, but air and light sensitive. Incompatible with acids, bases, strong oxidizing agents. Slightly hygroscopic.
LogP: 0.760 (est)
CAS DataBase Reference: 6533-68-2(CAS DataBase Reference)
EPA Substance Registry System: Scopolamine hydrobromide trihydrate (6533-68-2)

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Safety

Hazard Codes: T+
Risk Statements: 26/27/28
Safety Statements: 45-25-1
RIDADR: UN1544 6.1/PG 3
WGK Germany: 1
RTECS: YM4550000
HazardClass: 6.1
PackingGroup: III
HS Code: 29399990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Precautionary statements

P260Do not breathe dust/fume/gas/mist/vapours/spray.

P262Do not get in eyes, on skin, or on clothing.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: S0929
Product name: Scopolamine hydrobromide
Purity: meets USP testing specifications
Packaging: 1g
Price: $74.9
Updated: 2024/03/01

Sigma-Aldrich

Product number: PHR1470
Product name: Scopolamine Hydrobromide
Purity: Pharmaceutical Secondary Standard; Certified Reference Material
Packaging: 500mg
Price: $124
Updated: 2024/03/01

Sigma-Aldrich

Product number: S1875
Product name: (?)-Scopolamine hydrobromide trihydrate
Purity: ≥98% (HPLC), powder
Packaging: 1g
Price: $77.4
Updated: 2024/03/01

Sigma-Aldrich

Product number: S1875
Product name: (?)-Scopolamine hydrobromide trihydrate
Purity: ≥98% (HPLC), powder
Packaging: 5g
Price: $287
Updated: 2024/03/01

Sigma-Aldrich

Product number: S1875
Product name: (?)-Scopolamine hydrobromide trihydrate
Purity: ≥98% (HPLC), powder
Packaging: 25g
Price: $975
Updated: 2024/03/01

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Scopolamine Hydrobromide Trihydrate Chemical Properties,Usage,Production

Description

Scopolamine hydrobromide is a bronchodilator indicated for the maintenance treatment of chronic obstructive pulmonary disease (COPD), including chronic bronchitis and emphysema, the maintenance treatment of concomitant dyspnea and the prevention of acute exacerbations.

Chemical Properties

white crystalline solid

Uses

Scopolamine is a nasal decongestant and adrenergic agonist that is used to dilate the pupil, reduce eye focusing ability, control saliva and gastric acid production, slow intestinal movements, and prevent vomiting.

Definition

ChEBI: Scopolamine hydrobromide trihydrate is a hydrate that is the trihydrate form of scopolamine hydrobromide. It has a role as a mydriatic agent, a muscarinic antagonist, an anaesthesia adjuvant, an antispasmodic drug and an antiemetic. It contains a scopolamine hydrobromide (anhydrous).

brand name

Isopto Hyoscine (Alcon); Transderm-Scop (Ciba-Geigy).

General Description

White orthorhombic sphenoidal crystals from water. pH of 0.05 molar solution: 5.85.

Air & Water Reactions

Is sensitive to air, light and moisture. Slightly efflorescent in dry air.

Reactivity Profile

SCOPOLAMINE HYDROBROMIDE TRIHYDRATE is incompatible with acids, bases and oxidizing agents. .

Fire Hazard

Flash point data for SCOPOLAMINE HYDROBROMIDE TRIHYDRATE are not available. SCOPOLAMINE HYDROBROMIDE TRIHYDRATE is probably combustible.

Mode of action

Scopolamine Hydrobromide[6533-68-2] is a Belladonna Alkaloid with Anticholinergic Activity. It competitively inhibits muscarinic receptors of the parasympathetic nervous system for acetylcholine and act as a nonselective muscarinic antagonist, producing peripheral anti-muscarinic, central sedative and antiemetic effects. The parasympatholytic scopolamine, structurally very similar to atropine as well, is used in conditions requiring decreased parasympathetic activity. Therefore, scopolamine can inhibit the secretion of saliva and sweat, decrease gastrointestinal secretions and motility, and increase heart rate et al.

References

[1] KLINKENBERGINGE BloklandArjan. The validity of scopolamine as a pharmacological model for cognitive impairment: a review of animal behavioral studies.[J]. Neuroscience and Biobehavioral Reviews, 2010. DOI:10.1016/j.neubiorev.2010.04.001.
[2] CEYHAN T, KARTAL M, ALTUN M L, et al. LC determination of atropine sulfate and scopolamine hydrobromide in pharmaceuticals.[J]. Journal of pharmaceutical and biomedical analysis, 2001, 25 3-4: 399-406. DOI:10.1016/S0731-7085(00)00514-8.
[3] STEENKAMPP A. Fatal Datura poisoning: identification of atropine and scopolamine by high performance liquid chromatography/photodiode array/mass spectrometry.[J]. Forensic science international, 2004. DOI:10.1016/j.forsciint.2004.03.011.
[4] MUHTADI F J, HASSAN M M A. Analytical Profile Of Scopolamine Hydrobromide[C]//Vol. 19. 1990: 477-551. DOI:10.1016/S0099-5428(08)60376-7.

Scopolamine Hydrobromide Trihydrate Preparation Products And Raw materials

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Preparation Products

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View Lastest Price from Scopolamine Hydrobromide Trihydrate manufacturers

WUHAN FORTUNA CHEMICAL CO., LTD

Product: Scopolamine HBr trihydrate 6533-68-2
Price: US $0.00/g
Min. Order: 1g
Purity: 99%-102%;CP
Supply Ability: 1KG
Release date: 2021-06-07

Hebei Yanxi Chemical Co., Ltd.

Product: SCOPOLAMINE HYDROBROMIDE TRIHYDRATE 6533-68-2
Price: US $50.00/kg
Min. Order: 1kg
Purity: 0.99
Supply Ability: 10000
Release date: 2023-10-20

Anhui Zhongda Biotechnology Co., Ltd

Product: SCOPOLAMINE HYDROBROMIDE TRIHYDRATE 6533-68-2
Price: US $10.00/g
Min. Order: 1g
Purity: 99%
Supply Ability: 500tons
Release date: 2023-10-17

6533-68-2, Scopolamine Hydrobromide TrihydrateRelated Search:

Scopolamine Methscopolamine bromide Scopolamine butylbromide SCOPOLAMINE N-OXIDE HYDROBROMIDE HYOSCINE N BUTYL BROMIDE BP Scopolamine hydrobromide Scopine HYOSCINE HYDROCHLORIDE ATROPINE-D3 98 ATOM % D Scopolamine Hydrobromide Trihydrate ANISODAMINE HYDROBROMIDE SCOPOLAMINE-D3 HBR 3H2O (N-METHYL-D3) HYOSCYAMINE HYDROBROMIDE

(-)-SCOPOLAMINE HYDROBROMIDE TRIHYDRATE

Benzeneacetic acid, .alpha.-(hydroxymethyl)-, (1.alpha.,2.beta.,4.beta.,5.alpha.,7.beta.)-9-methyl-3-oxa-9-azatricyclo3.3.1.02,4non-7-yl ester, hydrobromide, trihydrate, (.alpha.S)-

SCOPOLAMINEHYDROBROMIDE,TRIHYDRATE,USP

(-)-Scopolamine trihydrate hydrobromide, Hyoscine hydrobromide, Scopine tropate

(-)-Scopolamine trihydrate hydrobromide

Hyoscine hydrobromide, Scopine tropate

Scopolamine-d3.HBr

(-)-Scopolamine hydrobromide trihydrate Hydrobromide Trihydrate

ScopolaMine HBr (Hyoscine HBr)

Benzeneacetic acid, a-(hydroxyMethyl)-, (1a,2b,4b,5a,7b)-9-Methyl-3-oxa-9-azatricyclo[3.3.1.02,4]non-7-ylester, hydrobroMide, hydrate (1:1:3), (aS)-

Scopolamine Hydrobromide (250 mg)

ScopolaMine-d3.HBr (Hyoscine-d3 HBr)

Scopolamine hydrobromide trihydrate, 99%, from Datura metel L.

C17H21NO4BRH3H2O

SCOPOLAMINE HYDROBROMIDE TRIHYDRATE

),hydrobromide,trihydrate

screen

tripton

ATROSCINE HYDROBROMIDE TRIHYDRATE

HYOSCINE HYDROBROMIDE TRIHYDRATE

SCOPOLAMINE HYDROBROMIDE USP

ScopolamineHydrobromideTrihydrate99%

Scopolaminhydrobromidetrihydrate

(1S,2R,4S,5S)-9-methyl-3-oxa-9-azatricyclo[3.3.1.0~2,4~]non-7-yl 3-hydroxy-2-phenylpropanoate hydrobromide trihydrate

9-methyl-3-oxa-9-azatricyclo[3.3.1.0~2,4~]non-7-yl 3-hydroxy-2-phenylpropanoate

(1S,2R,4S,5S)-9-methyl-3-oxa-9-azatricyclo[3.3.1.0~2,4~]non-7-yl 3-hydroxy-2-phenylpropanoate hydrobromid

(1R,5S)-9-methyl-3-oxa-9-azatricyclo[3.3.1.0~2,4~]non-7-yl (2S)-3-hydroxy-2-phenylpropanoate hydrobromide trihydrate

(1S,2R,4S,5S)-9-methyl-3-oxa-9-azatricyclo[3.3.1.0~2,4~]non-7-yl (2S)-3-hydroxy-2-phenylpropanoatato hydrobromide trihydrate

(-)-Scopolamine hydrobromide trihydrate Hydrobromide Trihydrate, ≥99%

Scopolamine Hydrobromide RS

Hyoscine hydrobromide trihydrate【(-)-Scopolamine hydrobromide trihydrate】

(-)-ScopolaminehydrobromidetrihydrateHydrobromideTrihydrate

East pol base hydrobromide

(1R,2R,4S,5S,7R)-9-methyl-3-oxa-9-azatricyclo[3.3 .1.0,2,4]nonan-7-yl (2S)-3-hydroxy-2-phenylpropanoate trihydrate hydrobromide

(1R,2R,4S,5S,7s)-9-methyl-3-oxa-9-azatricyclo[3.3.1.02,4]nonan-7-yl (S)-3-hydroxy-2-phenylpropanoate hydrobromide trihydrate

Scopolamine Hydrobromide TrihydrateQ: What is Scopolamine Hydrobromide Trihydrate Q: What is the CAS Number of Scopolamine Hydrobromide Trihydrate Q: What is the storage condition of Scopolamine Hydrobromide Trihydrate Q: What are the applications of Scopolamine Hydrobromide Trihydrate

Benzeneacetic acid, a-(hydroxymethyl)-,(1a,2b,4b,5a,7b)-9-methyl-3-oxa-9-azatricyclo[3.3.1.02,4]non-7-yl ester,hydrobromide, trihydrate, (aS)-

hydrogen (1S,2R,4S,5S)-9-methyl-3-oxa-9-azatricyclo[3.3.1.02,]nonan-7-yl (2S)-3-hydroxy-2-phenylpropanoate trihydrate bromide

Scopolamine Hydrobromide (1610001)

(1S,2R,4S,5S,7R)-9-methyl-3-oxa-9-azatricyclo[3.3.1.02,4]nonan-7-yl (S)-3-hydroxy-2-phenylpropanoate hydrobromide trihydrate

Hyoscyamine Sulfate Impurity D

Hyoscine Butylbromide EP Impurity A as Hydrobromide Trihydrate

Hyoscyamine Sulfate EP Impurity D

Hyoscyamine Sulfate EP Impurity D as Hydrobromide Trihydrate

Hyoscyamine Sulfate Impurity D as Hydrobromide Trihydrate

Scopolamine CRS.

Hyoscine Hydrobromide / Scopolamine Hydrobromide Trihydrate

(-)-Scopolamine hydrobromide trihydrate in methanol

Tiotropium Impurity 21

Atropine Impurity F as Hydrobromide Trihydrate

Atropine EP Impurity F as Hydrobromide Trihydrate

Atropine Impurity F (Hyoscine)

Hyoscine Butylbromide Impurity A as Hydrobromide Trihydrate

6533-68-2

65333-68-2

C17H22BrNO43H2O

C17H18D3NO4HBr

C17H28BrNO7