ChemicalBook > CAS DataBase List > 2,5-Dibromonitrobenzene
2,5-Dibromonitrobenzene
- Product Name
- 2,5-Dibromonitrobenzene
- CAS No.
- 3460-18-2
- Chemical Name
- 2,5-Dibromonitrobenzene
- Synonyms
- 1,4-DIBROMO-2-NITROBENZENE;Dibromonitrobenzene;2,5-Dibromonitrobenz;2,5-DIBROMONITROBENZENE;2-Nitro-1,4-dibromobenzene;1-Nitro-2,5-dibromobenzene;2, 5 - two br nitrobenzene;2,5-Dibromo-1-nitrobenzene;2,5-Dibromonitrobenzene,97%;2,5-DIBROMONITROBENZENE 99%
- CBNumber
- CB7311985
- Molecular Formula
- C6H3Br2NO2
- Formula Weight
- 280.9
- MOL File
- 3460-18-2.mol
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2,5-Dibromonitrobenzene Property
- Melting point:
- 82-84 °C (lit.)
- Boiling point:
- 266.4°C (rough estimate)
- Density
- 2.374 g/mL at 25 °C (lit.)
- refractive index
- 1.6400 (estimate)
- storage temp.
- Sealed in dry,Room Temperature
- form
- Crystalline Powder
- color
- Yellow
- Water Solubility
- Slightly soluble in water.
- BRN
- 1950425
- InChI
- InChI=1S/C6H3Br2NO2/c7-4-1-2-5(8)6(3-4)9(10)11/h1-3H
- InChIKey
- WRGKKASJBOREMB-UHFFFAOYSA-N
- SMILES
- C1(Br)=CC=C(Br)C=C1[N+]([O-])=O
- CAS DataBase Reference
- 3460-18-2(CAS DataBase Reference)
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Safety
- Hazard Codes
- Xn,N
- Risk Statements
- 22-36/37/38-50-20/21/22
- Safety Statements
- 26-60-61-36/37/39-22
- RIDADR
- UN 3077 9 / PGIII
- WGK Germany
- 2
- HazardClass
- 9
- HS Code
- 29049090
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Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
H400Very toxic to aquatic life
- Precautionary statements
-
P273Avoid release to the environment.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
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N-Bromosuccinimide Price
Sigma-Aldrich
- Product number
- D42003
- Product name
- 2,5-Dibromonitrobenzene
- Purity
- 99%
- Packaging
- 25g
- Price
- $39.6
- Updated
- 2025/07/31
Sigma-Aldrich
- Product number
- D42003
- Product name
- 2,5-Dibromonitrobenzene
- Purity
- 99%
- Packaging
- 100g
- Price
- $92.4
- Updated
- 2025/07/31
TCI Chemical
- Product number
- D0196
- Product name
- 1,4-Dibromo-2-nitrobenzene
- Purity
- >98.0%(GC)
- Packaging
- 25g
- Price
- $22
- Updated
- 2025/07/31
TCI Chemical
- Product number
- D0196
- Product name
- 1,4-Dibromo-2-nitrobenzene
- Purity
- >98.0%(GC)
- Packaging
- 250g
- Price
- $127
- Updated
- 2025/07/31
TRC
- Product number
- D425695
- Product name
- 2,5-Dibromonitrobenzene
- Packaging
- 25g
- Price
- $65
- Updated
- 2021/12/16
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2,5-Dibromonitrobenzene Chemical Properties,Usage,Production
Chemical Properties
white to light yellow crystal powder
Uses
2,5-Dibromonitrobenzene is a halogen-substituted nitrobenzenes used against Tetrahymena pyriformis due to its inhibitory and toxicity activities.
Synthesis
106-37-6
3460-18-2
The general procedure for the synthesis of 2,5-dibromonitrobenzene from 1,4-dibromobenzene was as follows: a mixture of nitric acid (90%, 4.6 g, 70 mmol) and concentrated sulfuric acid (75 mL) was slowly added dropwise to a solution of dichloromethane (30 mL) and concentrated sulfuric acid (20 mL) containing 1,4-dibromobenzene (11.8 g, 50 mmol), with the use of a dropping funnel during the addition. The acceleration of the drop was controlled and the reaction was carried out at room temperature for 20 min. After completion of the reaction, stirring of the reaction mixture was continued for 30 min. Subsequently, the reaction was quenched with 25% aqueous sodium hydroxide solution (3 mL), the reaction product was extracted with dichloromethane (30 mL) and the aqueous layer was washed with dichloromethane (10 mL). The organic phases were combined and dried over anhydrous magnesium sulfate. The solvent was removed by evaporation under reduced pressure to give the light yellow crystalline product 2,5-dibromonitrobenzene (13.7 g, 97% yield) with a melting point of 83-84°C. The product was extracted by 1H NMR and the aqueous layer was washed with dichloromethane (10 mL). The structure of the product was confirmed by 1H NMR (400 MHz, CDCl3), δ 7.98 (d, J = 2.3 Hz, 1H), 7.55-7.63 (m, 2H).
Purification Methods
It crystallises from Me2CO or EtOH. [Beilstein 5 H 250, 5 II 190, 5 III 621, 5 IV 732.]
References
[1] Tetrahedron, 2004, vol. 60, # 1, p. 81 - 92
[2] European Journal of Organic Chemistry, 2012, # 36, p. 7066 - 7074
[3] Dyes and Pigments, 2013, vol. 96, # 3, p. 619 - 625
[4] Journal of Materials Chemistry C, 2016, vol. 4, # 23, p. 5448 - 5460
[5] Organic Letters, 2001, vol. 3, # 7, p. 993 - 995
2,5-Dibromonitrobenzene Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 2,5-Dibromonitrobenzene manufacturers
Hebei Zhuanglai Chemical Trading Co Ltd
- Product
- 2,5-Dibromonitrobenzene 3460-18-2
- Price
- US $10.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 20 ton
- Release date
- 2024-11-28
Hebei Chuanghai Biotechnology Co., Ltd
- Product
- 2,5-Dibromonitrobenzene 3460-18-2
- Price
- US $0.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 500000kg
- Release date
- 2024-10-30
Shaanxi Dideu Medichem Co. Ltd
- Product
- 2,5-Dibromonitrobenzene 3460-18-2
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 20T
- Release date
- 2024-08-01
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