ChemicalBook > CAS DataBase List > 5,7-Dichloro-1,2,3,4-Tetrahydroisoquinoline-6-Carboxylic Acid Hydrochloride

5,7-Dichloro-1,2,3,4-Tetrahydroisoquinoline-6-Carboxylic Acid Hydrochloride

Uses

Product Name: 5,7-Dichloro-1,2,3,4-Tetrahydroisoquinoline-6-Carboxylic Acid Hydrochloride
CAS No.: 1289646-93-0
Chemical Name: 5,7-Dichloro-1,2,3,4-Tetrahydroisoquinoline-6-Carboxylic Acid Hydrochloride
Synonyms: 5,7-dichloro-1,2,3,4-tetrahydroisoquinoline-6-carboxylic acid hydrochloride;6-Isoquinolinecarboxylic acid, 5,7-dichloro-1,2,3,4-tetrahydro-, hydrochloride;Lifitegrast Impurity 5;lifitegrast-impurity IV-3;Lifitegrast Intermediate 2;Litakast Impurity 20 (hydrochloride);6-ISOQUINOLINECARBOXYLIC ACID,5,7-DICHLORO-1,2,3,4-TETRAHYDR...;6-Isoquinolinecarboxylic acid, 5,7-dichloro-1,2,3,4-tetrahydro-, hydroc;5,7-Dichloro-1,2,3,4-tetrahydro-6-isoquinolinecarboxylic acid hydrochloride (1:1);6-Isoquinolinecarboxylic acid, 5,7-dichloro-1,2,3,4-tetrahydro-, hydrochloride (1
CBNumber: CB73137955
Molecular Formula: C10H10Cl3NO2
Formula Weight: 282.55
MOL File: 1289646-93-0.mol

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5,7-Dichloro-1,2,3,4-Tetrahydroisoquinoline-6-Carboxylic Acid Hydrochloride Property

storage temp.: -20°C, sealed storage, away from moisture
Appearance: Off-white to light yellow Solid
InChI: InChI=1S/C10H9Cl2NO2.ClH/c11-7-3-5-4-13-2-1-6(5)9(12)8(7)10(14)15;/h3,13H,1-2,4H2,(H,14,15);1H
InChIKey: CGXSFPJGZFRGNL-UHFFFAOYSA-N
SMILES: ClC1C(=C(Cl)C=C2CNCCC=12)C(=O)O.Cl

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

AK Scientific

Product number: 8781EL
Product name: 5,7-Dichloro-1,2,3,4-tetrahydroisoquinoline-6-carboxylicacidhydrochloride
Packaging: 1g
Price: $532
Updated: 2021/12/16

AK Scientific

Product number: 8781EL
Product name: 5,7-Dichloro-1,2,3,4-tetrahydroisoquinoline-6-carboxylicacidhydrochloride
Packaging: 10g
Price: $2085
Updated: 2021/12/16

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5,7-Dichloro-1,2,3,4-Tetrahydroisoquinoline-6-Carboxylic Acid Hydrochloride Chemical Properties,Usage,Production

Uses

6-Isoquinolinecarboxylic acid, 5,7-dichloro-1,2,3,4-tetrahydro-, hydrochloride (1:1) is a quinoline derivative used in pharmaceutical synthesis.

General Description

5,7-Dichloro-1,2,3,4-Tetrahydroisoquinoline-6-Carboxylic Acid Hydrochloride, also known as Lifitegrast Impurity 5, is an impurity of Lifitegrast. Lifitegrast is a FDA approved drug for the treatment of keratoconjunctivitis sicca (dry eye syndrome). It is a tetrahydroisoquinoline derivative and lymphocyte function-associated antigen-1 ( LFA-1) antagonist that was discovered through the rational design process.

5,7-Dichloro-1,2,3,4-Tetrahydroisoquinoline-6-Carboxylic Acid Hydrochloride Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from 5,7-Dichloro-1,2,3,4-Tetrahydroisoquinoline-6-Carboxylic Acid Hydrochloride manufacturers

Guangzhou Tosun Pharmaceutical Limited

Product: Lifitegrast Impurity 5 1289646-93-0
Price: US $0.00-0.00/mg
Min. Order: 10mg
Purity: 98.49%
Supply Ability: 10g/month
Release date: 2023-05-10

Career Henan Chemical Co

Product: Lifitegrast Intermediate 2 1289646-93-0
Price: US $1.00/KG
Min. Order: 1KG
Purity: 98%
Supply Ability: 100KG
Release date: 2018-12-25

1289646-93-0, 5,7-Dichloro-1,2,3,4-Tetrahydroisoquinoline-6-Carboxylic Acid HydrochlorideRelated Search:

Lifitegrast Impurity 6 Lifitegrast Impurity 3 Lifitegrast Impurity 9 HCl Lifitegrast Impurity 8 2(1H)-Isoquinolinecarboxylic acid, 5,7-dichloro-3,4-dihydro-6-[[[(1S)-1-[[3-(methylsulfonyl)phenyl]methyl]-2-oxo-2-(phenylmethoxy)ethyl]amino]carbonyl]-, 1,1-dimethylethyl ester lifitegrast benzyl (S)-2-(2-(benzofuran-6-carbonyl)-5,7-dichloro-1,2,3,4-tetrahydroisoquinoline-6-carboxamido)-3-(3-(methylsulfonyl)phenyl)propanoate (R)-Benzyl 2-amino-3-(3-(methylsulfonyl)phenyl)propanoate hydrochloride Ethyl benzofuran-6-carboxylate L-Phenylalanine, N-[(5,7-dichloro-1,2,3,4-tetrahydro-6-isoquinolinyl)carbonyl]-3-(methylsulfonyl)-, phenylmethyl ester, hydrochloride (1:1) 5,7-Dichloro-1,2,3,4-Tetrahydroisoquinoline-6-Carboxylic Acid Hydrochloride

6-Isoquinolinecarboxylic acid, 5,7-dichloro-1,2,3,4-tetrahydro-, hydrochloride (1:1)

6-Isoquinolinecarboxylic acid, 5,7-dichloro-1,2,3,4-tetrahydro-, hydrochloride

5,7-dichloro-1,2,3,4-tetrahydroisoquinoline-6-carboxylic acid hydrochloride

6-Isoquinolinecarboxylic acid, 5,7-dichloro-1,2,3,4-tetrahydro-, hydrochloride (1

Lifitegrast Intermediate 2

Lifitegrast Impurity 5

5,7-Dichloro-1,2,3,4-tetrahydro-6-isoquinolinecarboxylic acid hydrochloride (1:1)

lifitegrast-impurity IV-3

6-ISOQUINOLINECARBOXYLIC ACID,5,7-DICHLORO-1,2,3,4-TETRAHYDR...

Litakast Impurity 20 (hydrochloride)

6-Isoquinolinecarboxylic acid, 5,7-dichloro-1,2,3,4-tetrahydro-, hydroc

1289646-93-0