ChemicalBook > CAS DataBase List > 2,4-Difluorotoluene

2,4-Difluorotoluene

Product Name
2,4-Difluorotoluene
CAS No.
452-76-6
Chemical Name
2,4-Difluorotoluene
Synonyms
2,4-Difluorobenzyl;difluorotoluene;2,4-DIFLUOROTOLUNE;2,4-DIFLUOROTOLUINE;2,4-DIFLUOROTOLUENE;2,4-Difluorotoluene99%;2,4-Difluorotoluene 99%;2,4-Difluorotoluene, 98+%;2.4-Difluoro methyl benzene;1-Methyl-2,4-difluorobenzene
CBNumber
CB7329212
Molecular Formula
C7H6F2
Formula Weight
128.12
MOL File
452-76-6.mol
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2,4-Difluorotoluene Property

Melting point:
-35 °C
Boiling point:
113-117 °C (lit.)
Density 
1.12 g/mL at 25 °C (lit.)
refractive index 
n20/D 1.449(lit.)
Flash point:
59 °F
storage temp. 
Sealed in dry,2-8°C
form 
Liquid
Specific Gravity
1.120
color 
Clear colorless
BRN 
1931681
InChI
InChI=1S/C7H6F2/c1-5-2-3-6(8)4-7(5)9/h2-4H,1H3
InChIKey
MPXDAIBTYWGBSL-UHFFFAOYSA-N
SMILES
C1(C)=CC=C(F)C=C1F
CAS DataBase Reference
452-76-6(CAS DataBase Reference)
NIST Chemistry Reference
2,4-Difluorotoluene(452-76-6)
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Safety

Hazard Codes 
F,F+
Risk Statements 
11
Safety Statements 
16-29-33
RIDADR 
UN 1993 3/PG 2
WGK Germany 
3
Hazard Note 
Flammable
HazardClass 
3
PackingGroup 
II
HS Code 
29039990
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H225Highly Flammable liquid and vapour

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.

P233Keep container tightly closed.

P240Ground/bond container and receiving equipment.

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P403+P235Store in a well-ventilated place. Keep cool.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

TCI Chemical
Product number
D2351
Product name
2,4-Difluorotoluene
Packaging
10g
Price
$69
Updated
2025/07/31
TRC
Product number
D452568
Product name
2,4-Difluorotoluene
Packaging
5g
Price
$75
Updated
2021/12/16
TRC
Product number
D452568
Product name
2,4-Difluorotoluene
Packaging
500mg
Price
$45
Updated
2021/12/16
TRC
Product number
D452568
Product name
2,4-Difluorotoluene
Packaging
1g
Price
$60
Updated
2021/12/16
Apolloscientific
Product number
PC2930
Product name
2,4-Difluorotoluene
Purity
98%
Packaging
25g
Price
$67
Updated
2021/12/16
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2,4-Difluorotoluene Chemical Properties,Usage,Production

Chemical Properties

colorless to light yellow liqui

Uses

2,4-Difluorotoluene was used in the synthesis of new hydrophobic isosteres of pyrimidines and purine nucleosides.

General Description

2,4-Difluorotoluene was synthesized as a nucleotide analog and was incorporated into DNA and undergoes replication by DNA polymerase enzymes.

Synthesis

108-88-3

352-32-9

95-52-3

352-70-5

452-76-6

452-67-5

2927-34-6

The general procedure for the synthesis of p-fluorotoluene, 2-fluorotoluene, 3-fluorotoluene, 2,4-difluorotoluene, 2,5-difluorotoluene, and 1,2-difluoro-4-methylbenzene from toluene is as follows: to a glass reactor fitted with a PTFE-lined magnetic stirring bar attached to a gas scrubbing flask were added toluene derivative (0.95-1.14 mmol), acetonitrile (1-2.5 mL/mmol of toluene derivative), and boron trifluoride ethyl ether complex (1.3-1.6 mmol/mmol of toluene derivative). mmol toluene derivative), acetonitrile (1-2.5 mL/mmol toluene derivative) and boron trifluoride ethyl ether complex (1.3-1.6 mmol/mmol toluene derivative). The reaction mixture was stirred at -25 °C for 10-15 min, followed by the addition of xenon difluoride (1.2-1.3 mmol/mmol toluene derivative) in batches. The reaction system was slowly warmed to 22 °C over 1 h and stirring was continued for 40-60 min. Upon completion of the reaction, hexafluorobenzene was added as an internal standard and samples were taken for 19F NMR analysis (Method B). The reaction mixture was quenched with saturated aqueous sodium bicarbonate and extracted with dichloromethane (1-2 mL). The combined organic phases were dried with anhydrous magnesium sulfate and subsequently analyzed by 19F NMR and GC/MS (Procedure C). The major products are listed in the table and others are shown below (GC/MS data).

References

[1] Russian Journal of Organic Chemistry, 2016, vol. 52, # 10, p. 1400 - 1407
[2] Zh. Org. Khim., 2016, vol. 52, # 10, p. 1412 - 1419,8

2,4-Difluorotoluene Preparation Products And Raw materials

Raw materials

Preparation Products

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2,4-Difluorotoluene Suppliers

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View Lastest Price from 2,4-Difluorotoluene manufacturers

Shaanxi Dideu Medichem Co. Ltd
Product
2,4-Difluorotoluene 452-76-6
Price
US $0.00-0.00/KG
Min. Order
50mg
Purity
99%HPLC
Supply Ability
2000tons
Release date
2020-01-08
Career Henan Chemical Co
Product
2,4-Difluorotoluene 452-76-6
Price
US $2.00/KG
Min. Order
1KG
Purity
98%MIN
Supply Ability
ASK
Release date
2019-12-25

452-76-6, 2,4-DifluorotolueneRelated Search:

Xylene 3-Fluorobenzotrifluoride 2-Methylbenzotrifluoride m-Xylene Tosufloxacin tosylate Benzotrifluoride o-Xylene Toluene 2,3,4,5,6-PENTAFLUOROBENZOPHENONE DECAFLUOROBENZOPHENONE 2,4-Difluorobenzoyl chloride OCTAFLUOROTOLUENE 2',3',4',5',6'-PENTAFLUOROACETOPHENONE DECAFLUOROBENZHYDROL Pentafluorobenzonitrile 2,3,4,5,6-PENTAFLUOROPHENYLACETIC ACID α-Bromo-2,3,4,5,6-pentafluorotoluene Decafluorobiphenyl

  • 1-Methyl-2,4-difluorobenzene
  • 2,4-Difluorotoluene, 98% 25GR
  • Benzene, 2,4-difluoro-1-methyl-
  • 2,4-DIFLUOROTOLUENE
  • 2,4-DIFLUOROTOLUINE
  • 2,4-DIFLUORO-1-METHYL-BENZENE
  • 2,4-DIFLUOROTOLUNE
  • 2.4-Difluoro methyl benzene
  • 2,4-Difluorotoluene, 98+%
  • 2,4-Difluorotoluene 99%
  • 2,4-Difluorotoluene99%
  • difluorotoluene
  • 2,4-Difluorobenzyl
  • 1,3-Difluoro-4-methylbenzene
  • 452-76-6
  • 2-76-6
  • FeC6H3CH3
  • CH3C6H3F2
  • Aryl
  • C7
  • Building Blocks
  • Organic Building Blocks
  • Halogenated Hydrocarbons
  • Halogen toluene
  • Miscellaneous
  • Aryl
  • C7
  • Halogenated Hydrocarbons
  • Aromatic Hydrocarbons (substituted) & Derivatives
  • Fluorinated benzene series
  • Fluorin-contained toluene series
  • Fluorobenzene