Acid-PEG1-t-butyl ester
- Product Name
- Acid-PEG1-t-butyl ester
- CAS No.
- 2086689-08-7
- Chemical Name
- Acid-PEG1-t-butyl ester
- Synonyms
- COOH-PEG1-OtBu;Acid-PEG1-C2-Boc;COOH-PEG1-COOtBu;Acid-PEG1-t-Bu Ester;Acid-PEG1-t-butyl ester;3-(3-(tert-Butoxy)-3-oxopropoxy)propanoic acid;3-(2-Carboxyethoxy)propanoic acid 1-tert-butyl ester;3-[3-[(2-methylpropan-2-yl)oxy]-3-oxopropoxy]propanoic acid;Propanoic acid, 3-(2-carboxyethoxy)-, 1-(1,1-dimethylethyl) ester
- CBNumber
- CB73303325
- Molecular Formula
- C10H18O5
- Formula Weight
- 218.25
- MOL File
- 2086689-08-7.mol
Acid-PEG1-t-butyl ester Property
- Boiling point:
- 341.9±22.0 °C(Predicted)
- Density
- 1.101±0.06 g/cm3(Predicted)
- storage temp.
- Storage temp. 2-8°C
- solubility
- Soluble in Water, DMSO, DCM, DMF
- form
- Liquid
- pka
- 4.27±0.10(Predicted)
- color
- Colorless to light yellow
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- C4153
- Product name
- 3-[3-(tert-Butoxy)-3-oxopropoxy]propanoic Acid
- Purity
- min. 98.0 %
- Packaging
- 250MG
- Price
- $129
- Updated
- 2026/03/19
- Product number
- BP-23509
- Product name
- Acid-PEG1-t-butylester
- Purity
- 98%
- Packaging
- 250mg
- Price
- $680
- Updated
- 2021/12/16
Acid-PEG1-t-butyl ester Chemical Properties,Usage,Production
Description
Acid-PEG1-t-butyl ester is a PEG linker containing a t-butyl protected carboxyl group with a terminal carboxylic acid. The terminal carboxylic acid can react with primary amine groups in the presence of activators (e.g. EDC, or HATU) to form a stable amide bond. The hydrophilic PEG spacer increases solubility in aqueous media. The t-butyl protected carboxyl group can be deprotected under acidic conditions.
Uses
Acid-PEG1-C2-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
IC 50
PEGs; Alkyl/ether
References
[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005
Acid-PEG1-t-butyl ester Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from Acid-PEG1-t-butyl ester manufacturers
- Product
- COOH-PEG1-COOtBu 2086689-08-7
- Price
- US $0.00/g
- Min. Order
- 1g
- Purity
- >98.00%
- Supply Ability
- 1g
- Release date
- 2024-03-23