NIFEDIPINE-D6

Product Name: NIFEDIPINE-D6
CAS No.: 1188266-14-9
Chemical Name: NIFEDIPINE-D6
Synonyms: Anifed-d6;Aldipin-d6;Adalate-d6;Cardiate-d6;Aldipine-d6;D6-Nifedipine;BAY-a-1040 D6;NIFEDIPINE-D6;1,4-dihydro-2,6-dimethyl-4-(2-nitrophenyl)-3,5-pyridinedicarboxylic Acid dimethyl Ester-d6;3,5-Pyridinedicarboxylic acid, 1,4-dihydro-2,6-dimethyl-4-(2-nitrophenyl)-, 3,5-di(methyl-d3) ester
CBNumber: CB7331022
Molecular Formula: C17H12D6N2O6
Formula Weight: 352.37
MOL File: Mol file

More

Less

NIFEDIPINE-D6 Property

Melting point:: 164-165°C
storage temp.: -20°C Freezer
solubility: Chloroform (Slightly), Methanol (Slightly, Heated)
form: Solid
color: Yellow

More

Less

Hazard and Precautionary Statements (GHS)

More

Less

N-Bromosuccinimide Price

Cayman Chemical

Product number: 25510
Product name: Nifedipine-d6
Purity: ≥99% deuterated forms (d1-d6)
Packaging: 500μg
Price: $141
Updated: 2024/03/01

Cayman Chemical

Product number: 25510
Product name: Nifedipine-d6
Purity: ≥99% deuterated forms (d1-d6)
Packaging: 1mg
Price: $253
Updated: 2024/03/01

TRC

Product number: N457002
Product name: Nifedipine-d6
Packaging: 10mg
Price: $1115
Updated: 2021/12/16

Medical Isotopes, Inc.

Product number: D4386
Product name: Nifedipine-d6
Packaging: 1mg
Price: $290
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: RDL0013355
Product name: NIFEDIPINE-D6
Purity: 95.00%
Packaging: 5MG
Price: $503.31
Updated: 2021/12/16

More

Less

NIFEDIPINE-D6 Chemical Properties,Usage,Production

Description

Nifedipine-d₆ is intended for use as an internal standard for the quantification of nifedipine by GC- or LC-MS. Nifedipine is a dihydropyridine L-type calcium channel blocker that reduces the amplitude of spontaneous contractions in isolated rabbit ileum when used at a concentration of 1 μM. Nifedipine (1 μM) reduces TGF-β-induced calcium oscillations in human fibroblasts and prevents impairment of lung function in a mouse model of pulmonary fibrosis induced by bleomycin when administered at a dose of 10 mg/kg per day. It also reduces increases in mean arterial blood pressure induced by angiotensin II in spontaneously hypertensive rats when administered at a dose of 10 μg/kg. Formulations containing nifedipine have been used in the treatment of hypertension and angina.

Chemical Properties

Yellow Solid

Uses

Used as an antihypertensive and antianginal. A labelled dihydorpyridine calcium channel blocker.

Uses

(Nifedipine-d6) Labeled Nifedipine, intended for use as an internal standard for the quantification of Nifedipine by GC- or LC-mass spectrometry.

References

[1] MERHAN RAGY Eman E. The role of nitric oxide and L-type calcium channel blocker in the contractility of rabbit ileum in vitro.[J]. Journal of physiology and biochemistry, 2012: 521-528. DOI: 10.1007/s13105-012-0167-x
[2] SUBHENDU MUKHERJEE. Disruption of Calcium Signaling in Fibroblasts and Attenuation of Bleomycin-Induced Fibrosis by Nifedipine.[J]. American Journal of Respiratory Cell and Molecular Biology, 2015, 53 4: 450-458. DOI: 10.1165/rcmb.2015-0009oc
[3] SHIZUKA ARITOMI Michihiro Y Tomoyuki Konda. L/N-type calcium channel blocker suppresses reflex aldosterone production induced by antihypertensive action.[J]. Heart and Vessels, 2012, 27 4: 419-423. DOI: 10.1007/s00380-011-0191-8

NIFEDIPINE-D6 Preparation Products And Raw materials

Raw materials

Preparation Products

More

Less

NIFEDIPINE-D6 Suppliers

Canada 3 China 43 India 4 United States 7 Global 57

J & K SCIENTIFIC LTD.

Tel: 18210857532; 18210857532
Fax: 86-10-82849933
Email: jkinfo@jkchemical.com
Country: China
ProdList: 96815
Advantage: 76

Chemsky（shanghai）International Co.,Ltd.

Tel: 021-50135380
Email: shchemsky@sina.com
Country: China
ProdList: 32321
Advantage: 50

MedChemexpress LLC

Tel: 021-58955995
Fax: 609-228-5909
Email: sales@medchemexpress.cn
Country: United States
ProdList: 4861
Advantage: 58

Cato Research Chemicals Inc.

Tel: 020-81960175
Fax: +1-541-2553641
Email: min.he@cato-chem.com
Country: China
ProdList: 1955
Advantage: 55

Artis Biotech Co. Ltd.

Tel: 028-67271278 18628360895
Fax: 0575-89298961
Email: sales@artisbio.com
Country: China
ProdList: 1960
Advantage: 58

Clearsynth Canada Inc.

Tel: +1.415.685.4395
Fax: +1.415.685.4395
Email: enquiry@clearsynth.com
Country: Canada
ProdList: 912
Advantage: 58

ShangHai Biochempartner Co.,Ltd

Tel: 177-54423994 17754423994
Fax: QQ:2853530913
Email: 2853530910@QQ.com
Country: China
ProdList: 8000
Advantage: 62

Amadis Chemical Company Limited

Tel: 571-89925085
Fax: 0086-571-89925065
Email: sales@amadischem.com
Country: China
ProdList: 131957
Advantage: 58

Shenzhen SUNGENING Bio-Medical Co., Ltd.

Tel: 0755-0755-28967200-8062 13631290199
Fax: 0755-28967200
Email: wxf@sungening.com
Country: China
ProdList: 9624
Advantage: 60

Chengdu Novel Biomedical Co., Ltd.

Tel: 028-85255396 18302801538
Fax: 028-85255396
Email: cdnovell@163.com
Country: China
ProdList: 2389
Advantage: 58

1188266-14-9, NIFEDIPINE-D6Related Search:

Nifedipine Vancomycin hydrochloride Nifedipine Pyrimidine Impurity nifedipine iMpurity C BROMOSULBACTAM sodium [2S-(2alpha,5alpha,6beta)]-6-bromo-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylate SulbactaM M-1 2,6-Ntp Nifedipine Impurity 9 methyl 2,4-bis{2-nitrophenyl}-6-methyl-1,2,3,4-tetrahydro-5-pyrimidinecarboxylate (S)-(+)-1,4-Dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylic Acid Monomethyl Ester (3S)-6,6-DIBROMO-2,2-DIMETHYLPENAM-3-CARBOXYLIC ACID 1,1-DIOXIDE Nifedipine Impurity 21 Methyl 3-aminocrotonate METHYL 2-(O-NITROBENZYLIDENE)-ACETOACETATE (E)-methyl 3-aminobut-2-enoate Sulbactam sodium 6,6-DIBROMOPENICILLANIC ACID

NIFEDIPINE-D6

1,4-dihydro-2,6-dimethyl-4-(2-nitrophenyl)-3,5-pyridinedicarboxylic Acid dimethyl Ester-d6

Adalate-d6

Aldipin-d6

Anifed-d6

Aldipine-d6

Cardiate-d6

BAY-a-1040 D6

Nifedipine D6Q: What is Nifedipine D6 Q: What is the CAS Number of Nifedipine D6 Q: What is the storage condition of Nifedipine D6 Q: What are the applications of Nifedipine D6

3,5-Pyridinedicarboxylic acid, 1,4-dihydro-2,6-dimethyl-4-(2-nitrophenyl)-, 3,5-di(methyl-d3) ester

D6-Nifedipine

1188266-14-9

C17H12D6N2O6

Intermediates & Fine Chemicals

Isotope Labeled Compounds

Pharmaceuticals

Dihydropyridine

Isotope Labelled Compounds

Dihydropyridine Class Chemicals