Boc-Asp-OH
- Product Name
- Boc-Asp-OH
- CAS No.
- 13726-67-5
- Chemical Name
- Boc-Asp-OH
- Synonyms
- BOC-ASP;BOC-L-ASP;ENC2372947;BOC-ASP-OH;BOC-L-ASP-OH;BOC-L-Aspatic;Boc-L-aspartate;Boc-Asp-OH, 〉98%;BOC-ASPARTIC ACID;Boc-L-Aspatic Acid
- CBNumber
- CB7332382
- Molecular Formula
- C9H15NO6
- Formula Weight
- 233.22
- MOL File
- 13726-67-5.mol
Boc-Asp-OH Property
- Melting point:
- 116-118 °C(lit.)
- alpha
- -6 º (c=1, MeOH)
- Boiling point:
- 375.46°C (rough estimate)
- Density
- 1.3397 (rough estimate)
- refractive index
- 1.4640 (estimate)
- storage temp.
- Keep in dark place,Sealed in dry,Room Temperature
- pka
- 3.77±0.23(Predicted)
- form
- Crystalline Powder
- color
- White to off-white
- optical activity
- [α]20/D 6.0°, c = 1 in methanol
- BRN
- 1913973
- CAS DataBase Reference
- 13726-67-5(CAS DataBase Reference)
Safety
- Hazard Codes
- Xn
- Risk Statements
- 20/21/22-36/37/38
- Safety Statements
- 26-36-24/25
- WGK Germany
- 3
- HS Code
- 2924 19 00
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P321Specific treatment (see … on this label).
P330Rinse mouth.
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P362Take off contaminated clothing and wash before reuse.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- 8.53070
- Product name
- Boc-Asp-OH
- Purity
- Novabiochem?
- Packaging
- 25g
- Price
- $46.4
- Updated
- 2025/07/31
- Product number
- 8.53070
- Product name
- Boc-Asp-OH
- Purity
- Novabiochem?
- Packaging
- 100g
- Price
- $118
- Updated
- 2025/07/31
- Product number
- 408468
- Product name
- Boc-Asp-OH
- Purity
- 99%
- Packaging
- 1g
- Price
- $11.4
- Updated
- 2023/06/20
- Product number
- B2270
- Product name
- N-(tert-Butoxycarbonyl)-L-aspartic Acid
- Purity
- >98.0%(HPLC)(T)
- Packaging
- 5g
- Price
- $47
- Updated
- 2025/07/31
- Product number
- 236078
- Product name
- Boc-Asp
- Packaging
- 1g
- Price
- $245
- Updated
- 2021/12/16
Boc-Asp-OH Chemical Properties,Usage,Production
Chemical Properties
white to off-white crystalline powder
Uses
N-Boc-L-aspartic acid is an N-Boc-protected form of L-Aspartic acid (A790024). L-Aspartic acid is a nonessential amino acid that is used to biosynthesize other amino acids within the human body. L-Aspartic acid also increases membrane conductance of mammalian neurons by voltage-dependent means, causing depolarization and nerve impulses that travel to key areas of the central nervous system.
Definition
ChEBI: Nalpha-(tert-butoxycarbonyl)-l-aspartic acid is an aspartic acid derivative.
reaction suitability
reaction type: Boc solid-phase peptide synthesis
Synthesis
56-84-8
24424-99-5
13726-67-5
GENERAL STEPS: In a 500 mL single-necked round-bottomed flask, L-aspartic acid (4 g, 30 mmol), 1,4-dioxane (120 mL) and deionized water (60 mL) were mixed to form a heterogeneous solution. Under continuous stirring, 1 M aqueous sodium hydroxide solution was added dropwise until the solution became homogeneous and clarified, indicating complete dissolution of L-aspartic acid. Subsequently, the reaction mixture was cooled in an ice bath and di-tert-butyl dicarbonate (7.2 g, 33 mmol) dissolved in 1,4-dioxane (20 mL) was added slowly and dropwise. The reaction mixture was stirred overnight at room temperature. Upon completion of the reaction, the solvent was partially evaporated using a rotary evaporator until the final volume was about 30 mL. ethyl acetate (20 mL) was then added and the aqueous layer was acidified to pH 2 with aqueous potassium bisulfate under ice-bath cooling conditions. the mixture was transferred to a partitioning funnel, and the product was extracted with ethyl acetate (3 aliquots at a time). The organic layers were combined and dried with anhydrous sodium sulfate. Subsequently, the solvent was evaporated using a rotary evaporator and further dried under vacuum overnight to give BOC-L-aspartic acid as a white solid (6 g, 85% yield).1H NMR (600 MHz, DMSO-d6) data: δ 1.38 (s, 9H), 2.51-2.55 (m, 1H), 2.65-2.69 (m, 1H). 4.24-4.28 (m, 1H), 7.05-7.07 (d, 1H, J = 12 Hz), 12.5 (s, 2H).
References
[1] Journal of the American Chemical Society, 2015, vol. 137, # 51, p. 16084 - 16097
[2] Patent: US2017/168042, 2017, A1. Location in patent: Paragraph 0203-0204
[3] Asian Journal of Chemistry, 2014, vol. 26, # 15, p. 4716 - 4722
[4] Patent: EP1647283, 2006, A1. Location in patent: Page/Page column 5
[5] Chemistry Letters, 1988, # 10, p. 1643 - 1646
Boc-Asp-OH Preparation Products And Raw materials
Raw materials
Preparation Products
Boc-Asp-OH Suppliers
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- Country
- Germany
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- Country
- Germany
- ProdList
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- Advantage
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View Lastest Price from Boc-Asp-OH manufacturers
- Product
- Boc-Asp-OH 13726-67-5
- Price
- US $0.00/Kg/Drum
- Min. Order
- 1KG
- Purity
- 98%min
- Supply Ability
- 500kgs
- Release date
- 2021-09-24
- Product
- Boc-L-Asp-OH 13726-67-5
- Price
- US $0.00-0.00/kg
- Min. Order
- 1kg
- Purity
- 98%
- Supply Ability
- 1T+
- Release date
- 2023-09-25
- Product
- Boc-Asp-OH 13726-67-5
- Price
- US $1.10/g
- Min. Order
- 1g
- Purity
- 99.0% min
- Supply Ability
- 100 tons min
- Release date
- 2021-05-25