Boc-L-aspartic acid 4-methyl ester

Product Name: Boc-L-aspartic acid 4-methyl ester
CAS No.: 59768-74-0
Chemical Name: Boc-L-aspartic acid 4-methyl ester
Synonyms: BOC-ASP(OME)-OH;Boc-L-Asp(OMe)-OH;BOC-ASP(OME)-OH DCHA;Boc-L-Asp(OMe)-OH·DCHA;boc-asp 4-methyl ester;REF DUPL: Boc-Asp(OMe)-OH;Boc-Asp(OMe)-OH >=98.0% (TLC);Boc-L-aspartate 4-methyl ester;N-Boc-asparic acid-b-methylester;(Tert-Butoxy)Carbonyl Asp(OMe)-OH
CBNumber: CB6287139
Molecular Formula: C10H17NO6
Formula Weight: 247.25
MOL File: 59768-74-0.mol

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Boc-L-aspartic acid 4-methyl ester Property

storage temp.: Sealed in dry,Room Temperature
solubility: Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
form: Solution
color: Clear colorless to yellow
BRN: 4810472
CAS DataBase Reference: 59768-74-0(CAS DataBase Reference)

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Safety

WGK Germany: 3
HS Code: 29241990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H302Harmful if swallowed

H314Causes severe skin burns and eye damage

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P310Immediately call a POISON CENTER or doctor/physician.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 15076
Product name: Boc-Asp(OMe)-OH
Purity: ≥98.0% (TLC)
Packaging: 5g
Price: $69
Updated: 2025/07/31

TRC

Product number: B621330
Product name: Boc-L-asparticAcidβ-MethylEster
Packaging: 2g
Price: $70
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FB15401
Product name: Boc-L-aspartic acid 4-methyl ester
Packaging: 25g
Price: $85
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: AAA0002899
Product name: BOC-ASP(OME)-OH
Purity: 95.00%
Packaging: 1G
Price: $135.45
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FB15401
Product name: Boc-L-aspartic acid 4-methyl ester
Packaging: 50g
Price: $155
Updated: 2021/12/16

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Boc-L-aspartic acid 4-methyl ester Chemical Properties,Usage,Production

Chemical Properties

White solid

Uses

Boc-L-aspartic Acid β-Methyl Ester is used to prepare isoxazoline glycoprotein IIb/IIIa antagonists. It is also used to synthesize glutamic acid analogs as potent inhibitors of leukotriene A4 hydrolase.

reaction suitability

reaction type: Boc solid-phase peptide synthesis

Synthesis

24424-99-5

16856-13-6

59768-74-0

3.74 g (20.5 mmol) of L-aspartic acid-β-methyl ester hydrochloride was dissolved in 85 mL of mixed dioxane/H2O (2:1) solvent and 2.21 g (20.8 mmol) of Na2CO3 was added at 0 °C. After the reaction was carried out for 30 min, 2.21 g (20.8 mmol) of Na2CO3 and 5 g (25.7 mmol) di-tert-butyl dicarbonate (Boc2O) and stirred at room temperature overnight. After completion of the reaction, the solvent was removed by vacuum concentration and the residue was poured into 60 mL of ice water. The aqueous layer was washed with ether (2 × 25 mL), followed by acidification with 100 mL of 1 M NaHSO4 to pH = 3, and then the aqueous layer was extracted with ether (3 × 75 mL). The organic layers were combined, dried with MgSO4, filtered and the solvent evaporated, and the residue was purified by column chromatography using ethyl acetate as eluent to afford the target product 2-(S)-(tert-butoxycarbonylamino)-(methoxycarbonyl)butanoic acid (Boc-L-aspartic acid 4-methyl ester) in 75% yield. The product was a white solid with an Rf value of 0.50 (ethyl acetate) and [α]D=+28.6 (c=0.3; CHCl3).IR (cm-1): 3429 (NH), 2979 (CH), 1714 (C=O), 1509, 1438, 1394, 1367, 1156, 1057, 1026, 843, 780, 734 .1H NMR (300 MHz, CDCl3): δ (ppm) = 1.42 (s, 9H, CH3), 2.82 (dd, J=4.8,17.2 Hz, 1H, CH2), 3.02 (dd, J=17.2,4.1 Hz, 1H, CH2), 3.69 (s, 3H, OCH3), 4.59-4.62 (m 1H, CHN), 5.57 (d, J=8.5Hz, 1H, NHBoc), 10.8 (sl, 1H, COOH).13C NMR (75MHz, CDCl3): δ (ppm) = 28.2 (CH3), 36.4 (CH2), 49.7 (CHN), 52.1 (OCH3), 80.5 (C(CH3)3 ), 155.6 (COO), 171.6 (COO), 175.8 (COO). Elemental analysis (C10H17NO6) calculated values: C 48.58, H 6.93, N 5.67; measured values: C 48.64, H 7.04, N 5.68.

References

[1] Heterocycles, 1997, vol. 46, # 1, p. 335 - 348
[2] Journal of Organic Chemistry, 1988, vol. 53, # 9, p. 1900 - 1903
[3] Chemical Communications, 2001, # 18, p. 1710 - 1711
[4] Patent: WO2013/30193, 2013, A1. Location in patent: Page/Page column 30; 31
[5] RSC Advances, 2015, vol. 5, # 88, p. 71868 - 71872

Boc-L-aspartic acid 4-methyl ester Preparation Products And Raw materials

Raw materials

Preparation Products

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Boc-L-aspartic acid 4-methyl ester Suppliers

China 162 Germany 2 India 9 Japan 3 Switzerland 3 United Kingdom 4 United States 21 Global 204

Meryer (Shanghai) Chemical Technology Co., Ltd.

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Shanghai Hanhong Scientific Co.,Ltd.

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View Lastest Price from Boc-L-aspartic acid 4-methyl ester manufacturers

Sichuan HongRi Pharma-Tech Co.,Ltd

Product: Boc-L-Asp(OMe)-OH 59768-74-0
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: 1T+
Release date: 2023-09-24

Career Henan Chemical Co

Product: Boc-L-aspartic acid 4-methyl ester 59768-74-0
Price: US $1.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 20kg
Release date: 2018-08-14

Career Henan Chemical Co

Product: Boc-L-aspartic acid 4-methyl ester 59768-74-0
Price: US $1.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 1000KG
Release date: 2018-08-15

59768-74-0, Boc-L-aspartic acid 4-methyl esterRelated Search:

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Boc-L-aspartic acid beta-Methyl ester

Boc-L-aspartic acid beta-Methyl ester dicyclohexylaMMoniuM salt

Boc-Asp(OMe)-OH >=98.0% (TLC)

N-Boc-L-aspartic acid 4-Methyl ester dicyclohexylaMMoniuM salt, 95%

Boc-L-Asp(OMe)-OH

Boc-L-Asp(OMe)-OH·DCHA

Boc-L-aspartic acid b-methyl ester dicyclohexylammonium salt≥ 98% (HPLC)

Boc-L-aspartic acid β-methyl ester≥ 99% (HPLC)

BOC-L-ASPARTIC ACID 4-METHYL ESTER

BOC-L-ASPARTIC ACID 4-METHYL ESTER DICYCLOHEXYLAMMONIUM SALT

BOC-L-ASPARATIC ACID-BETA-METHYL ESTER DCHA SALT

BOC-ASP(OME)-OH

BOC-ASP(OME)-OH DCHA

N-Boc-asparic acid-b-methylester

BOC-L-Aspartic acid 4-methyleester

BOC-L-ASPARATIC ACID-B-METHYLESTER DCHA SALT

(Tert-Butoxy)Carbonyl Asp(OMe)-OH

(S)-2-(tert-butoxycarbonylamino)-4-methoxy-4-oxobutanoic acid

REF DUPL: Boc-Asp(OMe)-OH

boc-asp 4-methyl ester

Boc-L-aspartic acid 4-methyl ester USP/EP/BP

Boc-L-aspartic acid β-methyl ester

4-Methyl hydrogen N-[(1,1-dimethylethoxy)carbonyl]-L-aspartate

Boc-L-aspartate 4-methyl ester

Boc-L-aspartic acid 4-methyl ester, 97%

4-Methyl hydrogen N-N-BOC-L-aspartate

59768-74-0

C10H17NO7C12H23N

CH3O2CCH2CHNHCO2CCH33CO2H

Aspartic Acid

Amino Acid Derivatives

Peptide Synthesis

Specialty Synthesis

Boc-Amino Acids

Boc-Amino acid series

Amino Acid Derivatives

Aspartic acid [Asp, D]

Boc-Amino Acids and Derivative