ChemicalBook > CAS DataBase List > GSK2837808A

GSK2837808A

Product Name
GSK2837808A
CAS No.
1445879-21-9
Chemical Name
GSK2837808A
Synonyms
GSK2837808A;GSK 2837808A (GSK2837808A);Inhibitor,inhibit,LDH,Lactate Dehydrogenase,GSK2837808A,GSK-2837808A;3-[[3-(cyclopropylsulfamoyl)-7-(2,4-dimethoxypyrimidin-5-yl)-4-quinolyl]amino]-5-(3,5-difluorophenoxy)benzoic acid;3-((3-(N-Cyclopropylsulfamoyl)-7-(2,4-dimethoxypyrimidin-5-yl)quinolin-4-yl)amino)-5-(3,5-difluorophenoxy)benzoic acid;3-[[3-[(Cyclopropylamino)sulfonyl]-7-(2,4-dimethoxy-5-pyrimidinyl)-4-quinolinyl]amino]-5-(3,5-difluorophenoxy)benzoic acid;Benzoic acid, 3-[[3-[(cyclopropylamino)sulfonyl]-7-(2,4-dimethoxy-5-pyrimidinyl)-4-quinolinyl]amino]-5-(3,5-difluorophenoxy)-
CBNumber
CB73333612
Molecular Formula
C31H25F2N5O7S
Formula Weight
649.62
MOL File
1445879-21-9.mol
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GSK2837808A Property

Boiling point:
783.5±70.0 °C(Predicted)
Density 
1.57±0.1 g/cm3(Predicted)
storage temp. 
Store at -20°C
solubility 
Soluble in DMSO
form 
crystalline solid
pka
3.81±0.10(Predicted)
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Cayman Chemical
Product number
20626
Product name
GSK2837808A
Purity
≥98%
Packaging
1mg
Price
$44
Updated
2024/03/01
Cayman Chemical
Product number
20626
Product name
GSK2837808A
Purity
≥98%
Packaging
5mg
Price
$183
Updated
2024/03/01
Cayman Chemical
Product number
20626
Product name
GSK2837808A
Purity
≥98%
Packaging
10mg
Price
$323
Updated
2024/03/01
Cayman Chemical
Product number
20626
Product name
GSK2837808A
Purity
≥98%
Packaging
25mg
Price
$684
Updated
2024/03/01
TRC
Product number
G797465
Product name
GSK2837808A
Packaging
5mg
Price
$360
Updated
2021/12/16
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GSK2837808A Chemical Properties,Usage,Production

Uses

GSK 2837808A may be lactate dehydrogenase A activity inhibitor.This compound is suitable for lactate dehydrogenase (LDH) related research.

Biological Activity

gsk2837808a is a potent, selective lactate dehydrogenase a (ldha) inhibitor (ic50 values are 1.9 and 14 nm for ldha and ldhb respectively).in snu398 but not hepg2 hepatocellular carcinoma cells. gsk2837808a (10 μm) reduces glucose consumption.after intravenous injection of gsk2837808a at 0.25 mg/kg in rats, the clearance is shown to be 69 ml/min/kg, which exceeds the blood flow of the animal liver. oral administration of gsk2837808a at 50 mg/kg or 100 mg/kg in rats or mice, respectively, resulted in blood compound levels reaching or below the detection limit of 2.5 ng/ml.[1]. billiard j, dennison j b, briand j, et al. quinoline 3-sulfonamides inhibit lactate dehydrogenase a and reverse aerobic glycolysis in cancer cells. cancer & metabolism, 2013, 1(1): 19-19.

storage

Store at -20°C

GSK2837808A Preparation Products And Raw materials

Raw materials

Preparation Products

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GSK2837808A Suppliers

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1445879-21-9, GSK2837808ARelated Search:

GSK6853 GSK-A1 S)-1-(sec-butyl)-N-((4,6-diMethyl-2-oxo-1,2-dihydropyridin-3-yl)Methyl)-3-Methyl-6-(6-(piperazin-1-yl)pyridin-3-yl)-1H-indole-4-carboxaMide GSK864 GSK484 GSK J4 HCl GSK 2334470 GSK2982772 GSK2636771 Benzeneacetamide, α-[[6-(4-amino-1-piperidinyl)-3,5-dicyano-4-ethyl-2-pyridinyl]thio]- GSK778 N-(6-Fluoro-1H-indazol-5-yl)-2-methyl-6-oxo-4-[4-(trifluoromethyl)phenyl]-1,4,5,6-tetrahydro-3-pyridinecarboxamide GSK 2033 2-((4-(benzo[d]thiazol-5-ylamino)-6-(tert-butylsulfonyl)quinazolin-7-yl)oxy)ethyl dihydrogen phosphate N-((S)-1-(4-((S)-2-(2,4-dichlorophenylsulfonaMido)-3-hydroxypropanoyl)piperazin-1-yl)-4-Methyl-1-oxopentan-2-yl)benzo[b]thiophene-2-carboxaMide GSK-2256098 GSK215

  • GSK2837808A
  • GSK 2837808A (GSK2837808A)
  • 3-[[3-[(Cyclopropylamino)sulfonyl]-7-(2,4-dimethoxy-5-pyrimidinyl)-4-quinolinyl]amino]-5-(3,5-difluorophenoxy)benzoic acid
  • Benzoic acid, 3-[[3-[(cyclopropylamino)sulfonyl]-7-(2,4-dimethoxy-5-pyrimidinyl)-4-quinolinyl]amino]-5-(3,5-difluorophenoxy)-
  • 3-((3-(N-Cyclopropylsulfamoyl)-7-(2,4-dimethoxypyrimidin-5-yl)quinolin-4-yl)amino)-5-(3,5-difluorophenoxy)benzoic acid
  • Inhibitor,inhibit,LDH,Lactate Dehydrogenase,GSK2837808A,GSK-2837808A
  • 3-[[3-(cyclopropylsulfamoyl)-7-(2,4-dimethoxypyrimidin-5-yl)-4-quinolyl]amino]-5-(3,5-difluorophenoxy)benzoic acid
  • 1445879-21-9
  • C31H25F2N5O7S