ChemicalBook > CAS DataBase List > CIS-ENTACAPONE

CIS-ENTACAPONE

Product Name
CIS-ENTACAPONE
CAS No.
145195-63-7
Chemical Name
CIS-ENTACAPONE
Synonyms
CIS-ENTACAPONE;(Z)-Entacapone;Entacapen impurity A;Entacapone-d10 (cis);Entacapone impurity A;Entacapone impurity A -I;Entacapone EP IMpurity A;Entacapone impurity A CRS;Entacapone Related CoMpound A;Z Entacapone/ EP impurity A/RC A
CBNumber
CB7334326
Molecular Formula
C14H15N3O5
Formula Weight
305.29
MOL File
145195-63-7.mol
More
Less

CIS-ENTACAPONE Property

Melting point:
142-144°C
Boiling point:
526.6±50.0 °C(Predicted)
Density 
1.392±0.06 g/cm3(Predicted)
storage temp. 
Hygroscopic, -20°C Freezer, Under Inert Atmosphere
solubility 
Dichloromethane (Slightly), Methanol (Slightly)
pka
5.15±0.50(Predicted)
color 
Yellow to Orange
More
Less

Safety

HS Code 
2926900005
More
Less

Hazard and Precautionary Statements (GHS)

More
Less

N-Bromosuccinimide Price

Sigma-Aldrich
Product number
Y0001250
Product name
Entacapone impurity A
Purity
European Pharmacopoeia (EP) Reference Standard
Packaging
y0001250
Price
$89.2
Updated
2024/03/01
Sigma-Aldrich
Product number
1235944
Product name
Entacapone impurity A
Packaging
25mg
Price
$1210
Updated
2024/03/01
Cayman Chemical
Product number
28046
Product name
cis-Entacapone
Packaging
1mg
Price
$121
Updated
2024/03/01
Cayman Chemical
Product number
28046
Product name
cis-Entacapone
Packaging
5mg
Price
$452
Updated
2024/03/01
TRC
Product number
E558490
Product name
cis-Entacapone
Packaging
50mg
Price
$1370
Updated
2021/12/16
More
Less

CIS-ENTACAPONE Chemical Properties,Usage,Production

Description

cis-Entacapone is a metabolite of the catechol-O-methyltransferase (COMT) inhibitor entacapone . It is also a potential impurity found in commercial preparations of entacapone and a degradant of entacapone formed by UV light exposure.

Chemical Properties

Orange Solid

Uses

cis-Entacapone (Entacapone EP Impurity A) is the (Z)-Isomer of Entacapone polymorphic form B. Antiparkinsonian.

Definition

ChEBI: 2-cyano-3-(3,4-dihydroxy-5-nitrophenyl)-N,N-diethyl-2-propenamide is a hydroxycinnamic acid.

CIS-ENTACAPONE Preparation Products And Raw materials

Raw materials

Preparation Products

More
Less

CIS-ENTACAPONE Suppliers

Canada 3 China 64 Europe 2 India 6 United Kingdom 2 United States 13 Global 90
Toronto Research Chemicals
Tel
--
Fax
--
Email
info@trc-canada.com
Country
Canada
ProdList
6038
Advantage
71
TLC PharmaChem Inc.
Tel
--
Fax
--
Email
research@tlcpharmachem.com
Country
Canada
ProdList
921
Advantage
60
SynFine Research, Inc.
Tel
--
Fax
--
Email
research@synfine.com.
Country
Canada
ProdList
768
Advantage
42

145195-63-7, CIS-ENTACAPONERelated Search:

Entacapone EP IMpurity B (alphaE)-alpha-[(3,4-Dihydroxy-5-nitrophenyl)methylene]-beta-oxo-1-piperidinepropanenitrile (2E)-2-Cyano-3-(3-ethoxy-4-hydroxy-5-nitrophenyl)-N,N-diethyl-2-propenamide Entacapone 3,5-DINITROCATECHOL Entacapone EP Impurity G (E/Z)-3-O-Methyl Entacapone (E)-3-O-Methyl Entacapone TYRPHOSTIN AG 1290 3,4-Dihydroxy-5-Nitrobenzoic Acid Entacapone EP IMpurity I 3-Nitro-4,5-dihydroxybenzaldehyde 2-Propenamide, 2-cyano-3-(3,4-dihydroxyphenyl)-N,N-diethyl-, (2E)- Entacapone Impurity 13 Entacapone 3-b-D-Glucuronide 6-Methoxy-2,4-dinitrophenol Entacapone Impurity 4 Entacapone Impurity 10

  • (2Z)-2-Cyano-3-(3,4-dihydroxy-5-nitrophenyl)-N,N-diethyl-2-propenamide
  • (Z)-Entacapone
  • CIS-ENTACAPONE
  • Entacapone impurity A -I
  • (Z)-2-cyano-3-(3,4-dihydroxy-5-nitrophenyl)-N,N-diethylprop-2-enamide
  • Entacapone Impurity 17(Entacapone EP Impurity A)
  • Entacapone Related Compound A (25 mg) ((Z)-2-cyano-3-(3,4-dihydroxy-5-nitrophenyl)-N,N-diethylacrylamide)
  • Entacapone EP IMpurity A
  • Entacapone Related CoMpound A
  • Entacapone impurity A
  • Entacapone Impurity 1（Entacapone EP Impurity A）
  • Entacapone EP Impurity A (cis-Entacapone)
  • Entacapone impurity A CRS
  • (2Z)-2-Cyano-3-(3,4-dihydroxy-5-nit
  • 2-Propenamide, 2-cyano-3-(3,4-dihydroxy-5-nitrophenyl)-N,N-diethyl-, (2Z)-
  • Entacapen impurity A
  • Z Entacapone/ EP impurity A/RC A
  • (Z)-2-cyano-3-(3,4-dihydroxy-5-nitrophenyl)-N,N-diethylacrylamide
  • Entacapone-d10 (cis)
  • Entacapone Related Compound A ((Z)-2-cyano-3-(3,4-dihydroxy-5-nitrophenyl)-N,N-diethylacrylamide) (1235944)
  • (2Z)-2-Cyano-3-(3,4-dihydroxy-5-nitrophenyl)-N,N-diethylprop-2-enamide
  • Entacapone USP Related Compound A
  • Entacapone Z-isomer / Entacapone Related Compound-A / Entacapone EP Impurity-A
  • Entacapone EP Impurity A (Entacapone USP Related Compound A, cis-Entacapone)
  • 145195-63-7
  • C14H15N3O5
  • Intermediates & Fine Chemicals
  • Pharmaceuticals