ChemicalBook > CAS DataBase List > CIS-ENTACAPONE

CIS-ENTACAPONE

Product Name: CIS-ENTACAPONE
CAS No.: 145195-63-7
Chemical Name: CIS-ENTACAPONE
Synonyms: CIS-ENTACAPONE;(Z)-Entacapone;Entacapen impurity A;Entacapone-d10 (cis);Entacapone impurity A;Entacapone impurity A -I;Entacapone EP IMpurity A;Entacapone impurity A CRS;Entacapone Related CoMpound A;Z Entacapone/ EP impurity A/RC A
CBNumber: CB7334326
Molecular Formula: C14H15N3O5
Formula Weight: 305.29
MOL File: 145195-63-7.mol

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CIS-ENTACAPONE Property

Melting point:: 142-144°C
Boiling point:: 526.6±50.0 °C(Predicted)
Density: 1.392±0.06 g/cm3(Predicted)
storage temp.: Hygroscopic, -20°C Freezer, Under Inert Atmosphere
solubility: Dichloromethane (Slightly), Methanol (Slightly)
pka: 5.15±0.50(Predicted)
color: Yellow to Orange

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Safety

HS Code: 2926900005

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: Y0001250
Product name: Entacapone impurity A
Purity: European Pharmacopoeia (EP) Reference Standard
Packaging: 10 mg
Price: $118
Updated: 2025/07/31

Sigma-Aldrich

Product number: PHR3444
Product name: Entacapone Related Compound A
Purity: certified reference material, pharmaceutical secondary standard
Packaging: 50 mg
Price: $570
Updated: 2025/07/31

Sigma-Aldrich

Product number: 1235944
Product name: Entacapone impurity A
Packaging: 25mg
Price: $1200
Updated: 2025/07/31

Sigma-Aldrich

Product number: Y0001250
Product name: Entacapone impurity A
Purity: European Pharmacopoeia (EP) Reference Standard
Packaging: y0001250
Price: $89.2
Updated: 2024/03/01

Cayman Chemical

Product number: 28046
Product name: cis-Entacapone
Packaging: 1mg
Price: $121
Updated: 2024/03/01

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CIS-ENTACAPONE Chemical Properties,Usage,Production

Description

cis-Entacapone is a metabolite of the catechol-O-methyltransferase (COMT) inhibitor entacapone . It is also a potential impurity found in commercial preparations of entacapone and a degradant of entacapone formed by UV light exposure.

Chemical Properties

Orange Solid

Uses

cis-Entacapone (Entacapone EP Impurity A) is the (Z)-Isomer of Entacapone polymorphic form B. Antiparkinsonian.

Definition

ChEBI: 2-cyano-3-(3,4-dihydroxy-5-nitrophenyl)-N,N-diethyl-2-propenamide is a hydroxycinnamic acid.

References

[1] T WIKBERG. Identification of major metabolites of the catechol-O-methyltransferase inhibitor entacapone in rats and humans.[J]. Drug Metabolism and Disposition, 1993, 21 1: 81-92.
[2] S. SARAVANAN R S. METHOD DEVELOPMENT AND VALIDATION FOR DETERMINATION OF IMPURITIES IN DEFERASIROX BY RP-HPLC TECHNIQUE[J]. Journal of Drug Delivery and Therapeutics, 2012, 34 1. DOI: 10.22270/jddt.v2i3.128
[3] NADEJDA SOUKHOVA. Development of characterization methods for entacapone in a pharmaceutical bulk[J]. Journal of pharmaceutical and biomedical analysis, 2011, 54 4: Pages 860-865. DOI: 10.1016/j.jpba.2010.10.019

CIS-ENTACAPONE Preparation Products And Raw materials

Raw materials

Preparation Products

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145195-63-7, CIS-ENTACAPONERelated Search:

Entacapone EP IMpurity B (alphaE)-alpha-[(3,4-Dihydroxy-5-nitrophenyl)methylene]-beta-oxo-1-piperidinepropanenitrile (2E)-2-Cyano-3-(3-ethoxy-4-hydroxy-5-nitrophenyl)-N,N-diethyl-2-propenamide Entacapone 3,5-DINITROCATECHOL Entacapone EP Impurity G (E/Z)-3-O-Methyl Entacapone (E)-3-O-Methyl Entacapone TYRPHOSTIN AG 1290 3,4-Dihydroxy-5-Nitrobenzoic Acid Entacapone EP IMpurity I 3-Nitro-4,5-dihydroxybenzaldehyde 2-Propenamide, 2-cyano-3-(3,4-dihydroxyphenyl)-N,N-diethyl-, (2E)- Entacapone Impurity 13 Entacapone 3-b-D-Glucuronide 6-Methoxy-2,4-dinitrophenol Entacapone Impurity 4 Entacapone Impurity 10

(2Z)-2-Cyano-3-(3,4-dihydroxy-5-nitrophenyl)-N,N-diethyl-2-propenamide

(Z)-Entacapone

CIS-ENTACAPONE

Entacapone impurity A -I

(Z)-2-cyano-3-(3,4-dihydroxy-5-nitrophenyl)-N,N-diethylprop-2-enamide

Entacapone Impurity 17(Entacapone EP Impurity A)

Entacapone Related Compound A (25 mg) ((Z)-2-cyano-3-(3,4-dihydroxy-5-nitrophenyl)-N,N-diethylacrylamide)

Entacapone EP IMpurity A

Entacapone Related CoMpound A

Entacapone impurity A

Entacapone Impurity 1（Entacapone EP Impurity A）

Entacapone EP Impurity A (cis-Entacapone)

Entacapone impurity A CRS

(2Z)-2-Cyano-3-(3,4-dihydroxy-5-nit

2-Propenamide, 2-cyano-3-(3,4-dihydroxy-5-nitrophenyl)-N,N-diethyl-, (2Z)-

Entacapen impurity A

Z Entacapone/ EP impurity A/RC A

(Z)-2-cyano-3-(3,4-dihydroxy-5-nitrophenyl)-N,N-diethylacrylamide

Entacapone-d10 (cis)

Entacapone Related Compound A ((Z)-2-cyano-3-(3,4-dihydroxy-5-nitrophenyl)-N,N-diethylacrylamide) (1235944)

(2Z)-2-Cyano-3-(3,4-dihydroxy-5-nitrophenyl)-N,N-diethylprop-2-enamide

Entacapone USP Related Compound A

Entacapone Z-isomer / Entacapone Related Compound-A / Entacapone EP Impurity-A

Entacapone EP Impurity A (Entacapone USP Related Compound A, cis-Entacapone)

145195-63-7

C14H15N3O5

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