3-Hydroxy-1-methylpiperidine Property

Boiling point:

76-78 °C11 mm Hg(lit.)

Density 

0.999 g/mL at 25 °C(lit.)

refractive index 

n20/D 1.475

Flash point:

158 °F

pka

14.95±0.20(Predicted)

form 

liquid

color 

Clear, orange

Water Solubility 

Fully misicible in water.

BRN 

103017

CAS DataBase Reference

3554-74-3(CAS DataBase Reference)

NIST Chemistry Reference

3-Piperidinol, 1-methyl-(3554-74-3)

EPA Substance Registry System

3-Piperidinol, 1-methyl- (3554-74-3)

Safety

Hazard Codes 

Xi

Risk Statements 

36/37/38-6/37/38

Safety Statements 

26-36

WGK Germany 

3

Hazard Note 

Irritant

TSCA 

Yes

HS Code 

29333990

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H227Combustible liquid

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

3-Hydroxy-1-methylpiperidine Chemical Properties,Usage,Production

Uses

Reactant for:• ;Optimization of Novobiocin scaffold to produce antitumor agents1• ;Formation of carbamates and N-alkylimidazoles2Reactant for synthesis of:• ;Pyridine derivatives as CDK5 inhibitors3• ;Phenylcarbamate derivatives as ligands for nicotinic acetylcholine receptors4• ;Amino phosphite ligands5• ;Mexiletine enantiomers by nucleophilic aromatic substitution6

Uses

Reactant for Optimization of Novobiocin scaffold to produce antitumor agents, Formation of carbamates and N-alkylimidazoles. Reactant for synthesis of Pyridine derivatives as CDK5 inhibitors Phenylcarbamate derivatives as ligands for nicotinic acetylcholine receptors, Amino phosphite ligands, Mexiletine enantiomers by nucleophilic aromatic substitution.

Uses

Reactant for:

• Optimization of Novobiocin scaffold to produce antitumor agents
• Formation of carbamates and N-alkylimidazoles

• Pyridine derivatives as CDK5 inhibitors
• Phenylcarbamate derivatives as ligands for nicotinic acetylcholine receptors
• Amino phosphite ligands
• Mexiletine enantiomers by nucleophilic aromatic substitution