4-OXO-PIPERIDINE-1,3-DICARBOXYLIC ACID 1-BENZYL ESTER 3-ETHYL ESTER
- Product Name
- 4-OXO-PIPERIDINE-1,3-DICARBOXYLIC ACID 1-BENZYL ESTER 3-ETHYL ESTER
- CAS No.
- 154548-45-5
- Chemical Name
- 4-OXO-PIPERIDINE-1,3-DICARBOXYLIC ACID 1-BENZYL ESTER 3-ETHYL ESTER
- Synonyms
- N-CBZ-3-carboethoxy-4-piperidone;ETHYL 1-BENZYLOXYCARBONYL-4-OXO-3-PIPERID;Ethyl 1-Cbz-4-oxopiperidine-3-carboxylate;1-Benzyl 3-ethyl 4-oxopiperidine-1,3-dicarboxylate;1-O-benzyl 3-O-ethyl 4-oxopiperidine-1,3-dicarboxylate;Ethyl 1-benzyloxycarbonyl-4-oxo-3-piperidinecarboxylate;4-OXO-PIPERIDINE-1,3-DICARBOXYLIC ACID 1-BENZYL ESTER 3-ETHYL ESTER;1,3-Piperidinedicarboxylic acid, 4-oxo-, 3-ethyl 1-(phenylmethyl) ester
- CBNumber
- CB7346020
- Molecular Formula
- C16H19NO5
- Formula Weight
- 305.33
- MOL File
- 154548-45-5.mol
4-OXO-PIPERIDINE-1,3-DICARBOXYLIC ACID 1-BENZYL ESTER 3-ETHYL ESTER Property
- Boiling point:
- 446.4±45.0 °C(Predicted)
- Density
- 1.238±0.06 g/cm3(Predicted)
- storage temp.
- Inert atmosphere,Room Temperature
- pka
- 11.06±0.20(Predicted)
- Appearance
- Colorless to light yellow Liquid
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- W3368
- Product name
- 4-Oxopiperidine-1,3-dicarboxylicacid1-benzylester3-ethylester
- Packaging
- 1g
- Price
- $281
- Updated
- 2021/12/16
- Product number
- 36162
- Product name
- 1-Benzyl3-ethyl4-oxopiperidine-1,3-dicarboxylate
- Purity
- 95+%
- Packaging
- 1g
- Price
- $460
- Updated
- 2021/12/16
- Product number
- CHM0095451
- Product name
- 4-OXO-PIPERIDINE-1,3-DICARBOXYLIC ACID 1-BENZYL ESTER 3-ETHYL ESTER
- Purity
- 95.00%
- Packaging
- 1G
- Price
- $984.06
- Updated
- 2021/12/16
- Product number
- 076004
- Product name
- 1-Benzyl 3-ethyl 4-oxopiperidine-1,3-dicarboxylate
- Purity
- 95+%
- Packaging
- 5g
- Price
- $998
- Updated
- 2021/12/16
- Product number
- 076004
- Product name
- 1-Benzyl 3-ethyl 4-oxopiperidine-1,3-dicarboxylate
- Purity
- 95+%
- Packaging
- 1g
- Price
- $370
- Updated
- 2021/12/16
4-OXO-PIPERIDINE-1,3-DICARBOXYLIC ACID 1-BENZYL ESTER 3-ETHYL ESTER Chemical Properties,Usage,Production
Synthesis
501-53-1
154548-45-5
The general procedure for the synthesis of benzyl ethyl 4-oxo-piperidine-1,3-dicarboxylate from benzyl chloroformate is as follows: a mixture of 1-benzyl-3-ethoxy-4-piperidone hydrochloride (89.0 g, 298.9 mmol) and palladium hydroxide (4.2 g, 5.9 mmol) in methanol (700 mL) was degassed and subjected to 40 psi hydrogen pressure by The reaction was shaken overnight. Upon completion of the reaction, the mixture was filtered through a diatomaceous earth pad and the filtrate was concentrated. The resulting solid was dissolved in dichloromethane (800 mL) and triethylamine (90.7 g, 897 mmol) was added. After cooling the solution to 0 °C, benzyl chloroformate (56.1 g, 329 mmol) was slowly added. The reaction mixture was stirred at 25 °C for 15 h. The reaction was subsequently quenched with water (500 mL). The aqueous layer was extracted with dichloromethane (2 x 400 mL), the organic layers were combined and dried over anhydrous magnesium sulfate and concentrated to give the crude product. The crude product was purified by silica gel column chromatography (eluent ratio of petroleum ether: ethyl acetate = 5:1) to afford benzyl ethyl 4-oxo-piperidine-1,3-dicarboxylate (72 g, 78% yield), which could be used for subsequent reactions without further purification.
References
[1] Patent: WO2005/49033, 2005, A1. Location in patent: Page/Page column 123
4-OXO-PIPERIDINE-1,3-DICARBOXYLIC ACID 1-BENZYL ESTER 3-ETHYL ESTER Preparation Products And Raw materials
Raw materials
Preparation Products
4-OXO-PIPERIDINE-1,3-DICARBOXYLIC ACID 1-BENZYL ESTER 3-ETHYL ESTER Suppliers
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- Country
- United Kingdom
- ProdList
- 6565
- Advantage
- 38
View Lastest Price from 4-OXO-PIPERIDINE-1,3-DICARBOXYLIC ACID 1-BENZYL ESTER 3-ETHYL ESTER manufacturers
- Product
- 4-OXO-PIPERIDINE-1,3-DICARBOXYLIC ACID 1-BENZYL ESTER 3-ETHYL ESTER 154548-45-5
- Price
- US $6.68/KG
- Min. Order
- 1KG
- Purity
- 97%-99%
- Supply Ability
- 1kg-1000kg
- Release date
- 2020-01-10
- Product
- 4-OXO-PIPERIDINE-1,3-DICARBOXYLIC ACID 1-BENZYL ESTER 3-ETHYL ESTER 154548-45-5
- Price
- US $6.68/KG
- Min. Order
- 1KG
- Purity
- 97%-99%
- Supply Ability
- 1kg-1000kg
- Release date
- 2020-01-10