10,10-BIS(4-PYRIDINYLMETHYL)-9(10H)-ANTHRACENONE DIHYDROCHLORIDE

Product Name: 10,10-BIS(4-PYRIDINYLMETHYL)-9(10H)-ANTHRACENONE DIHYDROCHLORIDE
CAS No.: 122955-42-4
Chemical Name: 10,10-BIS(4-PYRIDINYLMETHYL)-9(10H)-ANTHRACENONE DIHYDROCHLORIDE
Synonyms: XE 991;XE9912HCl;XE991, 10 mM in DMSO;XE 991 DIHYDROCHLORIDE;10,10-Bis(pyridin-4-ylmethyl)anthracen-9(10H)-one;9(10H)-Anthracenone, 10,10-bis(4-pyridinylmethyl)-;10-bis(4-Pyridinylmethyl)-9(10H)-anthracenone dihydrochloride;10,10-BIS(4-PYRIDINYLMETHYL)-9(10H)-ANTHRACENONE DIHYDROCHLORIDE
CBNumber: CB7349263
Molecular Formula: C26H20N2O
Formula Weight: 376.45
MOL File: 122955-42-4.mol

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10,10-BIS(4-PYRIDINYLMETHYL)-9(10H)-ANTHRACENONE DIHYDROCHLORIDE Property

Melting point:: 231-232 °C
Boiling point:: 585.0±38.0 °C(Predicted)
Density: 1.238±0.06 g/cm3(Predicted)
storage temp.: 2-8°C
solubility: DMSO: >20mg/mL
form: solid
pka: 6.08±0.10(Predicted)
color: white to beige
Water Solubility: Soluble in water (100mM)

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Safety

Hazard Codes: Xi
Risk Statements: 36/37/38
Safety Statements: 26-36
WGK Germany: 3
RTECS: CB1530000

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: X2254
Product name: XE-991
Purity: ≥98% (HPLC)
Packaging: 10mg
Price: $174
Updated: 2024/03/01

Sigma-Aldrich

Product number: X2254
Product name: XE-991
Purity: ≥98% (HPLC)
Packaging: 50mg
Price: $738
Updated: 2024/03/01

Tocris

Product number: 2000
Product name: XE991dihydrochloride
Purity: ≥99%(HPLC)
Packaging: 50
Price: $780
Updated: 2021/12/16

Tocris

Product number: 2000
Product name: XE991dihydrochloride
Purity: ≥99%(HPLC)
Packaging: 10
Price: $187
Updated: 2021/12/16

TRC

Product number: X750953
Product name: XE991
Packaging: 5mg
Price: $220
Updated: 2021/12/16

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10,10-BIS(4-PYRIDINYLMETHYL)-9(10H)-ANTHRACENONE DIHYDROCHLORIDE Chemical Properties,Usage,Production

Uses

XE-991 has been used as a KCNQ (Kv7.2/7.3) inhibitor to examine whether M-current inhibition affects oxytocin receptor (TGOT) mediated depolarization. It has also been used as an KCNQ inhibitor to study the ionic mechanism responsible for the overshoot/undershoot in membrane potential in mouse cholinergic interneurons (ChIs) in the presence of tetrodotoxin (TTX).

Biological Activity

Potent and selective blocker of KCNQ voltage-gated potassium channels. Blocks KCNQ2+3/M-currents (IC 50 = 0.6-0.98 μ M) and KCNQ1 homomeric channels (IC 50 = 0.75 μ M) but is less potent against KCNQ1/minK channels (IC 50 = 11.1 μ M). Augments hippocampal ACh release and is a cognitive enhancer following oral administration in vivo .

Biochem/physiol Actions

XE-991 is a KCNQ channel blocker; which is more potent than linopiridine (Cat. No. L-134).

storage

Room temperature (desiccate)

10,10-BIS(4-PYRIDINYLMETHYL)-9(10H)-ANTHRACENONE DIHYDROCHLORIDE Preparation Products And Raw materials

Raw materials

Preparation Products

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10,10-BIS(4-PYRIDINYLMETHYL)-9(10H)-ANTHRACENONE DIHYDROCHLORIDE Suppliers

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122955-42-4, 10,10-BIS(4-PYRIDINYLMETHYL)-9(10H)-ANTHRACENONE DIHYDROCHLORIDERelated Search:

XENOLIGHT D-LUCIFERIN POTASSIUM SALT XEN907 10,10-Dimethylanthrone 4,4'-Trimethylenedipyridine 10,10-BIS(4-PYRIDINYLMETHYL)-9(10H)-ANTHRACENONE DIHYDROCHLORIDE XE 991 dihydrochloride

10,10-BIS(4-PYRIDINYLMETHYL)-9(10H)-ANTHRACENONE DIHYDROCHLORIDE

XE9912HCl

XE 991

XE 991 DIHYDROCHLORIDE

10-bis(4-Pyridinylmethyl)-9(10H)-anthracenone dihydrochloride

9(10H)-Anthracenone, 10,10-bis(4-pyridinylmethyl)-

10,10-Bis(pyridin-4-ylmethyl)anthracen-9(10H)-one

XE991, 10 mM in DMSO

122955-42-4

C26H20N2O2HCl

Ion Channels

Potassium channel