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DL-tert-Leucine

Product Name
DL-tert-Leucine
CAS No.
33105-81-6
Chemical Name
DL-tert-Leucine
Synonyms
L-TLE;D-L-Tle;H-TLE-OH;DL-Tle-OH;T-LEUCINE;H-L-TLE-OH;H-DL-TLE-OH;TBU-GLYCINE;L-T-LEUCINE;tert-leucine
CBNumber
CB7349551
Molecular Formula
C6H13NO2
Formula Weight
131.17
MOL File
33105-81-6.mol
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DL-tert-Leucine Property

Melting point:
>300 °C (lit.)
Boiling point:
242.49°C (rough estimate)
Density 
1.0975 (rough estimate)
refractive index 
1.4240 (estimate)
storage temp. 
Keep in dark place,Inert atmosphere,Room temperature
solubility 
H2O: 0.1 g/mL, clear, colorless
pka
2.39±0.12(Predicted)
form 
Solid
color 
White to off-white
Water Solubility 
soluble
BRN 
1721823
InChI
InChI=1S/C6H13NO2/c1-6(2,3)4(7)5(8)9/h4H,7H2,1-3H3,(H,8,9)
InChIKey
NPDBDJFLKKQMCM-UHFFFAOYSA-N
SMILES
C(O)(=O)C(C(C)(C)C)N
CAS DataBase Reference
33105-81-6(CAS DataBase Reference)
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Safety

Safety Statements 
22-24/25
WGK Germany 
3
HS Code 
29224995
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P321Specific treatment (see … on this label).

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P362Take off contaminated clothing and wash before reuse.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
332178
Product name
DL-tert-Leucine
Purity
98%
Packaging
500mg
Price
$131
Updated
2023/06/20
TCI Chemical
Product number
L0439
Product name
H-DL-Tle-OH
Packaging
5G
Price
$62
Updated
2025/07/31
TCI Chemical
Product number
L0439
Product name
H-DL-Tle-OH
Packaging
25G
Price
$186
Updated
2025/07/31
Usbiological
Product number
290597
Product name
DL-tert-Butylglycine
Packaging
10g
Price
$908
Updated
2021/12/16
TRC
Product number
L330205
Product name
Dl-tert-leucine
Packaging
250mg
Price
$55
Updated
2021/12/16
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DL-tert-Leucine Chemical Properties,Usage,Production

Chemical Properties

white powder

Uses

peptide synthesis

Definition

ChEBI: Tert-butylglycine is a glycine derivative that is glycine with a tertiary butyl group at position 2. It has a role as a metabolite.

reaction suitability

reaction type: solution phase peptide synthesis

Synthesis

26782-71-8

33105-81-6

The general procedure for synthesizing DL-tert-leucine from D-tert-leucine is as follows: Example 3A: A 30% ammonium hydroxide solution (50 mL) was added to the autoclave, followed by D-tert-leucine (5 g). The autoclave was sealed and the mixture was heated to 85°C under stirring conditions and maintained at this temperature for 12 hours of reaction. Upon completion of the reaction, the reaction mixture was cooled and the solution was transferred to a rotary evaporator and concentrated under vacuum at 55 °C. The solid residue obtained after concentration was mixed with acetone (20 mL) with stirring, followed by filtration and drying to finally obtain DL-tert-leucine (4.6 g, 92% yield, of which the L-isomer accounted for 42% and the D-isomer for 58%).

References

[1] Patent: US2012/245379, 2012, A1. Location in patent: Page/Page column 3
[2] Patent: EP2502896, 2012, A1. Location in patent: Page/Page column 4-5

DL-tert-Leucine Preparation Products And Raw materials

Raw materials

Preparation Products

(R)-TERT-LEUCINOL
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DL-tert-Leucine Suppliers

Belgium 2 Canada 1 China 156 Europe 1 France 1 Germany 7 India 6 Japan 4 Switzerland 3 The Netherlands 1 Ukraine 2 United Kingdom 9 United States 34 Global 227
SIGMA-RBI
Tel
--
Fax
--
Country
Switzerland
ProdList
6896
Advantage
91
Senn Chemicals AG
Tel
--
Fax
--
Email
swiss@sennchem.com
Country
Switzerland
ProdList
3143
Advantage
71
Biosynth AG
Tel
--
Fax
--
Email
welcome@biosynth.ch
Country
Switzerland
ProdList
3324
Advantage
72
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View Lastest Price from DL-tert-Leucine manufacturers

Career Henan Chemical Co
Product
DL-tert-Leucine 33105-81-6
Price
US $1.00/KG
Min. Order
1KG
Purity
98%
Supply Ability
200kg
Release date
2018-12-24

33105-81-6, DL-tert-LeucineRelated Search:

6-Aminocaproic acid N-CARBOBENZOXY-DL-LEUCINE Methyl 4-tert-butylbenzoate Diethylstilbestrol tert-Butanol Glycine tert-Butyl methyl ether L-Leucine 4-tert-Butylcatechol ALTRENOGEST L-tert-Leucine tert-Butyl hydroperoxide tert-Butylbenzene tert-Butyldimethylsilyl chloride 2-tert-Butylphenol D-tert-Butylglycine Tris(hydroxymethyl)aminomethane DL-Leucine

  • Valine, 3-methyl-
  • DL-Tle-OH
  • tert-DL-LEUCINE extrapure
  • tert-leucine
  • (±)-2-Amino-3,3-dimethylbutyric acid, DL-α-tert-Butylglycine
  • DL-tert-Butylglycine,99%
  • DL-tert-ButylglycineDL-tert-Leucine
  • TERT-BUTYLGLYCINE
  • L-ALPHA-T-BUTYLGLYCINE
  • L-ALPHA-T-BUTYL-GLY-OH
  • L-ALPHA-TERT-BUTYLGLYCINE
  • DL-tert-Leucine 98%
  • DL-α-tert-Butyl-Gly-OH
  • H-TBU-DL-GLY-OH
  • H-TBU-GLY-OH
  • H-TLE-OH
  • H-ALPHA-T-BUTYLGLYCINE
  • H-ALPHA-T-BUTYLGLYCINE-OH
  • H-L-TLE-OH
  • H-DL-TLE-OH
  • H-DL-(TBU)GLY-OH
  • DL-ALPHA-T-BUTYLGLYCINE
  • DL-ALPHA-T-BUTYL-GLY-OH
  • DL-ALPHA-TERT-BUTYLGLYCINE
  • DL-TERT-BUTYLGLYCINE
  • DL-TERT-LEUCINE
  • DL-T-BUTYLGLYCINE
  • DL-T-LEUCINE
  • T-LEUCINE
  • TIMTEC-BB SBB006594
  • (+/-)-2-Amino-3,3-dimethylbutyric acid~DL-2-(tert-Butyl)glycine~H-DL-Tle-OH
  • L-Tert-Leucine HCl
  • 3-METHYL-L-VALINE
  • 3-METHYL VALINE
  • (S)-TERT-LEUCINE
  • TBU-DL-GLYCINE
  • TBU-GLYCINE
  • T-BUTYLGLYCINE
  • T-DL-LEUCINE
  • (S)-2-AMINO-3,3-DIMETHYLBUTYRIC ACID
  • (R,S)-2-AMINO-3,3-DIMETHYL-BUTYRIC ACID
  • L-T-BUTYLGLYCINE
  • L-TLE
  • L-(+)-T-LEUCINE
  • L-T-LEUCINE
  • 2-AMINO-3,3-DIMETHYLBUTANOIC ACID
  • (+/-)-2-AMINO-3,3-DIMETHYLBUTYRIC ACID
  • 2-AMINO-3,3-DIMETHYL BUTYRIC ACID
  • 2-amino-3,3-dimethylbutanoicaci
  • DL-tert-Leucine USP/EP/BP
  • DL-α-tert-Butylglycine
  • D-L-Tle
  • DL-tert-Leucine,95%
  • <sc>DL</sc>-<i>tert</i>-Leucine
  • 33105-81-6
  • 20859-20-3
  • 20895-02-3
  • CH33CCHNH2COOH